Neurotoxins acting at nicotinic receptors

Autor: Daniel Bertrand, Ron C Hogg

Publikováno v: Future Neurology. 3:463-472

Neurotoxins include, in the most general sense, all molecules that destroy or inhibit the proper functioning of the nervous system. Neurotoxins from animals and plants include alkaloids and peptides, many of which interact with physiological processe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e7ec979b3a9ad970b99d0462b139302
https://doi.org/10.2217/14796708.3.4.463

An automated system for intracellular and intranuclear injection

Autor: Roland Dosch, Audrey Benoit, Ron C Hogg, Florence Bandelier, Daniel Bertrand

Publikováno v: Journal of Neuroscience Methods, Vol. 169, No 1 (2008) pp. 65-75

The Xenopus oocyte expression system has played an important role in the study of cellular proteins, particularly in the field of membrane physiology; expression of transporters and ion channels has significantly advanced our knowledge of these membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835f8afc45856d7bc35ff0c6f0460926
https://doi.org/10.1016/j.jneumeth.2007.11.028

Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors

Autor: Ron C. Hogg, Daniel Bertrand

Publikováno v: Biochemical Pharmacology. 73:459-468

Improved understanding of how brain function is altered in neurodegenerative disease states, pain and conditions, such as schizophrenia and attention deficit disorder, has highlighted the role of nicotinic acetylcholine receptors (nAChRs) in these co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b2b1e67049ffa45b16c61aeafa2cc2
https://doi.org/10.1016/j.bcp.2006.08.010

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP

Autor: C. Ulens, Victor I. Tsetlin, Titia K. Sixma, August B. Smit, Patrick H.N. Celie, Ron C. Hogg, Daniel Bertrand

Publikováno v: Ulens, C, Hogg, R C, Celie, P H, Bertrand, D, Tsetlin, V, Smit, A B & Sixma, T K 2006, ' Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP ', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 3615-3620 . https://doi.org/10.1073/pnas.0507889103
Proceedings of the National Academy of Sciences of the United States of America, 103, 3615-3620. National Acad Sciences

The nicotinic acetylcholine receptor (nAChR) is the prototype member of the superfamily of pentameric ligand-gated ion channels. How the extracellular ligand-binding domain coordinates selective binding of ligand molecules to different subtypes of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ea269d4c705d4f446aa4c39db3555b
https://doi.org/10.1073/pnas.0507889103

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant

Autor: Dmitry Y. Mordvintsev, Sarah E. van Rossum-Fikkert, Victor I. Tsetlin, René van Elk, August B. Smit, Daniel Bertrand, Maxim N. Zhmak, Titia K. Sixma, Patrick H.N. Celie, Ron C. Hogg, Igor E. Kasheverov, Pim van Nierop

Publikováno v: Celie, P H N, Kasheverov, I E, Mordventisev, D Y, Hogg, R C, van Nierop, P, van Elk, R, van Rossum-Fikkert, S E, Zhmak, M N, Bertrand, D, Tsetlin, V, Sixma, T K & Smit, A B 2005, ' Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant ', Nature Structural and Molecular Biology, vol. 12, no. 7, pp. 582-588 . https://doi.org/10.1038/nsmb951
Nature Structural and Molecular Biology, 12(7), 582-588. Nature Publishing Group

Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a broad spectrum of ion channels and receptors. The subgroup alpha-Ctx specifically and selectively binds to subtypes of nicotinic acetylcholine receptors (nACh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ba41c5b1ea529aa2a3a8d3246956a1
https://research.vu.nl/en/publications/c50f9ec6-5a02-42d0-a4ef-b4ca33dd90a2