Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ron C, Kelly"'
Publikováno v:
Pharmaceutical Development and Technology. 27:511-524
The challenges of working with hygroscopic pharmaceutical raw materials can have a significant impact on the industry's ability to make high-quality medicines. In order to mitigate the impact to the manufacturing process or product quality it is crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dd6b2827e6b3ff8c2bff81e4b3d018
https://doi.org/10.1080/10837450.2022.2084105
https://doi.org/10.1080/10837450.2022.2084105
Autor:
Gwenaella Rescourio, Ana Z. Gonzalez, Salman Jabri, Brian Belmontes, Gordon Moody, Doug Whittington, Xin Huang, Sean Caenepeel, Mario Cardozo, Alan C. Cheng, David Chow, Hannah Dou, Adrie Jones, Ron C. Kelly, Yihong Li, Mike Lizarzaburu, Mei-Chu Lo, Rommel Mallari, Cesar Meleza, Yosup Rew, Scott Simonovich, Daqing Sun, Simon Turcotte, Xuelei Yan, Simon G. Wong, Evelyn Yanez, Manuel Zancanella, Jonathan Houze, Julio C. Medina, Paul E. Hughes, Sean P. Brown
Publikováno v:
Journal of Medicinal Chemistry. 62:10258-10271
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive therapeutic target for the treatment of certain types of tumors. Herein, we report our efforts towar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e56bfd1df312774368ff5b90efcd7cc
https://doi.org/10.1021/acs.jmedchem.9b01310
https://doi.org/10.1021/acs.jmedchem.9b01310
Autor:
Jon Hilden, Timothy T. Kramer, John Strong, Ilgaz Akseli, Chen Mao, Jeffrey M. Katz, Frederick Osei-Yeboah, Ron C. Kelly
Publikováno v:
Journal of Pharmaceutical Sciences. 108:1081-1084
The bulk properties of a powder are dependent on the preparation, treatment, and storage of the sample, that is, how it was handled. The particles can be packed to have a range of bulk densities and, moreover, the slightest disturbance of the powder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4ad595e38ec36978ee02c5cb014663
https://doi.org/10.1016/j.xphs.2018.10.009
https://doi.org/10.1016/j.xphs.2018.10.009
Publikováno v:
Journal of pharmaceutical sciences. 107(12)
Since the discovery of X-ray diffraction and its potential to elucidate crystal symmetry, powder X-ray diffraction has found diverse applications in the field of pharmaceutical sciences. This review summarizes significant achievements of the techniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6c7772f293c3e9205719ac22403021
https://pubmed.ncbi.nlm.nih.gov/30145209
https://pubmed.ncbi.nlm.nih.gov/30145209
Autor:
Andrew Tasker, Andreas Reichelt, Yi-Ling Hu, Deanna Mohn, John McCarter, Ben Fisher, Robert M. Rzasa, Yi Chen, Julio C. Medina, Gang Yu, Sharon Wannberg, Brian Lucas, Ron C. Kelly, Jennifer Seganish, Felix Gonzalez-Lopez de Turiso, Xiaolin Hao, Kristin L. Andrews, Douglas A. Whittington, Matthew Frank Brown, Dawei Zhang, Youngsook Shin, Mario G. Cardozo, Jason Duquette, Robert C. Wahl, Leeanne Zalameda, Daniela Metz, Vatee Pattaropong, Michael G. Johnson, Tisha San Miguel, Randall W. Hungate, John Whoriskey, Lawrence R. McGee, Timothy D. Cushing, Kirk Henne, Liping H. Pettus, Xiao He
Publikováno v:
Journal of Medicinal Chemistry. 58:480-511
The development and optimization of a series of quinolinylpurines as potent and selective PI3Kδ kinase inhibitors with excellent physicochemical properties are described. This medicinal chemistry effort led to the identification of 1 (AMG319), a com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f464b8458b3d559ce036ed30580e01
https://doi.org/10.1021/jm501624r
https://doi.org/10.1021/jm501624r
Publikováno v:
Journal of pharmaceutical sciences. 106(3)
The challenge of bringing innovative medicines to patients in combination with intense competition within the pharmaceutical industry has induced companies to develop quality medicines more efficiently and cost-effectively. State-of-the-art approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb7f77c7dcfac327cc041f3e8b2df79
https://pubmed.ncbi.nlm.nih.gov/27915208
https://pubmed.ncbi.nlm.nih.gov/27915208
Autor:
Felix, Gonzalez-Lopez de Turiso, Xiaolin, Hao, Youngsook, Shin, Minna, Bui, Iain D G, Campuzano, Mario, Cardozo, Michelle C, Dunn, Jason, Duquette, Benjamin, Fisher, Robert S, Foti, Kirk, Henne, Xiao, He, Yi-Ling, Hu, Ron C, Kelly, Michael G, Johnson, Brian S, Lucas, John, McCarter, Lawrence R, McGee, Julio C, Medina, Daniela, Metz, Tisha, San Miguel, Deanna, Mohn, Thuy, Tran, Christine, Vissinga, Sharon, Wannberg, Douglas A, Whittington, John, Whoriskey, Gang, Yu, Leeanne, Zalameda, Xuxia, Zhang, Timothy D, Cushing
Publikováno v:
Journal of medicinal chemistry. 59(15)
Optimization of the potency and pharmacokinetic profile of 2,3,4-trisubstituted quinoline, 4, led to the discovery of two potent, selective, and orally bioavailable PI3Kδ inhibitors, 6a (AM-0687) and 7 (AM-1430). On the basis of their improved profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a242cbf7d7efba8c63b94dcec247686e
https://pubmed.ncbi.nlm.nih.gov/27411843
https://pubmed.ncbi.nlm.nih.gov/27411843
Publikováno v:
CrystEngComm. 13:1170-1180
Fifteen cocrystals, four cocrystal polymorphs, one cocrystal hydrate, two free base solvates and one free base hydrate of N-(4-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide (FB) were successfully prepared by milling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47c575d0a5a0067e5c6c8f34028bbf25
https://doi.org/10.1039/c0ce00544d
https://doi.org/10.1039/c0ce00544d
Autor:
Hua Tu, Lisa Julian, Nigel Walker, Maren Gulsrud Willcockson, Yosup Rew, Michael DeGraffenreid, Zhulun Wang, Juan C. Jaen, Daqing Sun, Ron C. Kelly, Athena Sudom, Seb Caille, Jacob Kaizerman, Jay P. Powers, Xuelei Yan, Qiuping Ye, Stefania Ursu, Ben Jiang, Felix Gonzalez-Lopez de Turiso, Randall W. Hungate, Dustin McMinn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:405-410
The synthesis and SAR of a series of 4,4-disubstituted cyclohexylbenzamide inhibitors of 11β-HSD1 are described. Optimization rapidly led to potent, highly selective, and orally bioavailable inhibitors demonstrating efficacy in both rat and non-huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d541a6a690483f033c76a34f9400098
https://doi.org/10.1016/j.bmcl.2010.10.129
https://doi.org/10.1016/j.bmcl.2010.10.129
Autor:
Ron C. Kelly, Naír Rodríguez-Hornedo
Publikováno v:
Organic Process Research & Development. 13:1291-1300
This contribution reports the effects of molecular recognition events and solubility on the crystallization of carbamazepine (CBZ) polymorphs from organic solvents. Solvents were chosen on the basi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6121c7039d5e3739953d7a6da90f2aaa
https://doi.org/10.1021/op900133z
https://doi.org/10.1021/op900133z