Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ron Aoyama"'
Autor:
John Prescott, Marcia Belvin, Sanh Tan Lam, Ron Aoyama, Blake T. Aftab, Yongchang Shi, Klaus P. Hoeflich, Edna F. Choo, Geoffrey Del Rosario, Congfen Li, Peiwen Yu, Jean-Francois Martini, Lillian Lee, Joseph A. Ware, Amy Peterson, Laurent Vernillet, Harvey Wong
PDF file, 66KB, Plot of observed versus predicted GDC-0973 plasma concentrations following fitting of PK model (Figure 1A) to mean GDC-0973 plasma concentration-time data from patients in cohort 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be78dc48256c8cf14c7446f9f4f9582f
https://doi.org/10.1158/1078-0432.22445543
https://doi.org/10.1158/1078-0432.22445543
Autor:
John Prescott, Marcia Belvin, Sanh Tan Lam, Ron Aoyama, Blake T. Aftab, Yongchang Shi, Klaus P. Hoeflich, Edna F. Choo, Geoffrey Del Rosario, Congfen Li, Peiwen Yu, Jean-Francois Martini, Lillian Lee, Joseph A. Ware, Amy Peterson, Laurent Vernillet, Harvey Wong
PDF file, 57KB, Structure of GDC-0973.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e24f522dbb0b50d80f365a3ee1b197
https://doi.org/10.1158/1078-0432.22445549
https://doi.org/10.1158/1078-0432.22445549
Autor:
John Prescott, Marcia Belvin, Sanh Tan Lam, Ron Aoyama, Blake T. Aftab, Yongchang Shi, Klaus P. Hoeflich, Edna F. Choo, Geoffrey Del Rosario, Congfen Li, Peiwen Yu, Jean-Francois Martini, Lillian Lee, Joseph A. Ware, Amy Peterson, Laurent Vernillet, Harvey Wong
PDF file, 83KB, Representative Western blots of ERK1/2 and total ERK1/2 of tumor tissue homogenate collected from WM-266-4 xenograft studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7e214c0d73712c80f6679b926764bd
https://doi.org/10.1158/1078-0432.22445546
https://doi.org/10.1158/1078-0432.22445546
Autor:
John Prescott, Marcia Belvin, Sanh Tan Lam, Ron Aoyama, Blake T. Aftab, Yongchang Shi, Klaus P. Hoeflich, Edna F. Choo, Geoffrey Del Rosario, Congfen Li, Peiwen Yu, Jean-Francois Martini, Lillian Lee, Joseph A. Ware, Amy Peterson, Laurent Vernillet, Harvey Wong
PDF file, 62KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b79c31c8a8d1d6f041186dfe2f04b4
https://doi.org/10.1158/1078-0432.22445540
https://doi.org/10.1158/1078-0432.22445540
Autor:
John Prescott, Marcia Belvin, Sanh Tan Lam, Ron Aoyama, Blake T. Aftab, Yongchang Shi, Klaus P. Hoeflich, Edna F. Choo, Geoffrey Del Rosario, Congfen Li, Peiwen Yu, Jean-Francois Martini, Lillian Lee, Joseph A. Ware, Amy Peterson, Laurent Vernillet, Harvey Wong
Purpose: GDC-0973 is a potent and selective mitogen-activated protein (MAP)/extracellular signal–regulated kinase (ERK) kinase (MEK) inhibitor. Pharmacokinetic–pharmacodynamic (PK–PD) modeling was used to relate GDC-0973 plasma and tumor concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4896b9e52f75db9f68117175df950d53
https://doi.org/10.1158/1078-0432.c.6520511.v1
https://doi.org/10.1158/1078-0432.c.6520511.v1
Autor:
John Prescott, Marcia Belvin, Sanh Tan Lam, Ron Aoyama, Blake T. Aftab, Yongchang Shi, Klaus P. Hoeflich, Edna F. Choo, Geoffrey Del Rosario, Congfen Li, Peiwen Yu, Jean-Francois Martini, Lillian Lee, Joseph A. Ware, Amy Peterson, Laurent Vernillet, Harvey Wong
PDF file, 72KB, Summary of pharmacokinetic parameters estimated from fitting PK model from WM-266-4 xenograft studies (Figure 1A) to GDC-0973 concentration-time data from humans.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c59582abd8f25dfc3d5e2684ab73fa
https://doi.org/10.1158/1078-0432.22445537.v1
https://doi.org/10.1158/1078-0432.22445537.v1
Autor:
Leanna Lagpacan, Christopher Allen Ziebenhaus, Bruno Marchand, Elfatih Elzein, Jason K. Perry, Bernard P. Murray, Scott Preston Simonovich, Parkhill Eric Q, Armando G. Villaseñor, WaiLok K. Hung, Nikos Pagratis, Rao Kalla, Jeff Zablocki, Dmitry Koltun, John R. Somoza, Timothy R. Hansen, Ron Aoyama, Thao Perry, Magdeleine Hung, Xiaofen Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(3)
We hereby disclose the discovery of inhibitors of CaMKII (7h and 7i) that are highly potent in rat ventricular myocytes, selective against hERG and other off-target kinases, while possessing good CaMKII tissue isoform selectivity (cardiac γ/δ vs. n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caba80ce7be1413193b5f5243755c5aa
https://pubmed.ncbi.nlm.nih.gov/29254643
https://pubmed.ncbi.nlm.nih.gov/29254643
Autor:
John Woolfrey, Craig Stacy Takeuchi, Arthur Plonowski, Kyoko Yamaguchi, Ron Aoyama, Byung Gyu Kim, Anagha Abhijit Joshi, Paul Foster, Sunghoon Ma, Sharmila Rajan, Tae Gon Baik, Naing Aay, Arlyn Arcalas, Charles M. Blazey, Jonah Cannoy, Peter Lamb, Isabelle Lehoux, Chris A. Buhr, Narsimha Munagala, Matthew Sangyup Lee, John M. Nuss, James W. Leahy, Jae Lee, Sergey Epshteyn, Neel Kumar Anand, Nicole Miller, Longcheng Wang, Katherine Lara, Henry Johnson
Publikováno v:
Journal of Medicinal Chemistry. 56:2218-2234
A series of novel, highly potent, selective, and ATP-competitive mammalian target of rapamycin (mTOR) inhibitors based on a benzoxazepine scaffold have been identified. Lead optimization resulted in the discovery of inhibitors with low nanomolar acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37d108d9c419238d27ed27c967013b5
https://doi.org/10.1021/jm3007933
https://doi.org/10.1021/jm3007933
Autor:
Sanh Tan Lam, Edna F. Choo, Lillian Lee, Harvey Wong, Amy C. Peterson, Congfen Li, Yongchang Shi, Klaus P. Hoeflich, John Prescott, Geoffrey Del Rosario, Marcia Belvin, Jean-Francois Martini, Ron Aoyama, Peiwen Yu, Joeseph A Ware, Blake T. Aftab, Laurent Vernillet
Publikováno v:
Clinical Cancer Research. 18:3090-3099
Purpose: GDC-0973 is a potent and selective mitogen-activated protein (MAP)/extracellular signal–regulated kinase (ERK) kinase (MEK) inhibitor. Pharmacokinetic–pharmacodynamic (PK–PD) modeling was used to relate GDC-0973 plasma and tumor concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afddce05a73ecd664670ea98a745ceb1
https://doi.org/10.1158/1078-0432.ccr-12-0445
https://doi.org/10.1158/1078-0432.ccr-12-0445
Autor:
Danny Tam, Amanda Harrison, Jason August Nachtigall, Fawn Qian, Ron Aoyama, Jon Rosen, Peter Lamb, Tao Wang, Artur Plonowski, Belinda Cancilla, Naing Aay, Elena S. Koltun, Patrick Kearney, Adam A. Galan, Arlyn Arcalas, Kwang-Ai Won, Wentao Zhang, Raju Mohan, Hongwang Du, Vicky Chan, Art Hanel, Patricia Finn, Michael Yakes, Jeff Zhang, Richards Steven J, Frauke Bentzien, John M. Nuss, Kathy Ogilvie, Christopher J. Larson
Publikováno v:
Journal of Medicinal Chemistry. 55:4322-4335
Targeting glycosphingolipid synthesis has emerged as a novel approach for treating metabolic diseases. 32 (EXEL-0346) represents a new class of glucosylceramide synthase (GCS) inhibitors. This report details the elaboration of hit 8 with the goal of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd8c748fee52922d91c2b98ea12917f
https://doi.org/10.1021/jm300122u
https://doi.org/10.1021/jm300122u