Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Romy Steiner"'
Autor:
Moritz Muckenhuber, Konstantinos Mengrelis, Anna Marianne Weijler, Romy Steiner, Verena Kainz, Marlena Buresch, Heinz Regele, Sophia Derdak, Anna Kubetz, Thomas Wekerle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The efficacy of costimulation blockade with CTLA4-Ig (belatacept) in transplantation is limited due to T cell-mediated rejection, which also persists after induction with anti-thymocyte globulin (ATG). Here, we investigate why ATG fails to p
Externí odkaz:
https://doaj.org/article/7a33667422cf46129bf79b0e8be234ff
Autor:
Lisa Prickler, Ulrike Baranyi, Konstantinos Mengrelis, Anna Marianne Weijler, Verena Kainz, Bernhard Kratzer, Romy Steiner, Jasmin Mucha, Elisa Rudoph, Nina Pilat, Barbara Bohle, Herbert Strobl, Winfried Franz Pickl, Rudolf Valenta, Birgit Linhart, Thomas Wekerle
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionProphylactic strategies to prevent the development of allergies by establishing tolerance remain an unmet medical need. We previously reported that the transfer of autologous hematopoietic stem cells (HSC) expressing the major timothy gra
Externí odkaz:
https://doaj.org/article/a785c8ea646145588ea6e987232eb280
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The importance and exact role of graft-resident leucocytes (also referred to as passenger leucocytes) in transplantation is controversial as these cells have been reported to either initiate or retard graft rejection. T cell activation to allografts
Externí odkaz:
https://doaj.org/article/68eb7f9e7dcd428b85c5b90a689eb8c0
Publikováno v:
Aging Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4fe734160f5badaede13ef0b6b5a920
https://doi.org/10.1111/acel.13824
https://doi.org/10.1111/acel.13824
Autor:
Cristiano Amarelli, Nina Pilat, Olivier Thaunat, Sophie Brouard, Christine S. Falk, Federica Casiraghi, Floriane Fusil, Nuria Montserrat, Katia Lefsihane, Katja Kotsch, Romy Steiner
Publikováno v:
Transplant International. 34:1594-1606
Cell therapy has emerged as an attractive therapeutic option in organ transplantation. During the last decade, the therapeutic potency of Treg immunotherapy has been shown in various preclinical animal models and safety was demonstrated in first clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f9a01c2871c860eedfc29e21c9ffee
https://doi.org/10.1111/tri.13972
https://doi.org/10.1111/tri.13972
Autor:
Nina Pilat, Romy Steiner
Publikováno v:
Clinical and experimental immunology.
Since the discovery of regulatory T cells (Tregs) as crucial regulators of immune tolerance against self-antigens, these cells have become a promising tool for the induction of donor-specific tolerance in transplantation medicine. The therapeutic pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d47bf46a47d2a78f897a770c9d9a9e
https://pubmed.ncbi.nlm.nih.gov/36562079
https://pubmed.ncbi.nlm.nih.gov/36562079
Autor:
Thomas Wekerle, Lukas Unger, Mario Wiletel, Anna M. Weijler, Romy Steiner, Nicolas Granofszky, Heinz Regele, Moritz Muckenhuber, Lisa Dorner, Nina Pilat, Benedikt Mahr
Publikováno v:
American Journal of Transplantation
Eliminating cytoreductive conditioning from chimerism‐based tolerance protocols would facilitate clinical translation. Here we investigated the impact of major histocompatibility complex (MHC) and minor histocompatibility antigen (MiHA) barriers on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029b03e8f1168d21a80b3b11cb5d89f6
http://europepmc.org/articles/PMC7984377
http://europepmc.org/articles/PMC7984377
Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice
Autor:
Elmar Krause, Gertrud Schwär, Maik Konrad, Annette Lis, Romy Steiner, Adrian Angenendt, Arne Knörck
Publikováno v:
Aging. 12:3266-3286
Ca2+ is a crucial second messenger for proper T cell function. Considering the relevance of Ca2+ signals for T cell functionality it is surprising that no mechanistic insights into T cell Ca2+ signals from elderly individuals are reported. The main C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02ed705154d3eae5753b476528a20d86
https://doi.org/10.18632/aging.102809
https://doi.org/10.18632/aging.102809
Publikováno v:
International Journal of Molecular Sciences. 24:1752
The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2153426106df940cf143c12e0b6b902c
https://doi.org/10.3390/ijms24021752
https://doi.org/10.3390/ijms24021752
Autor:
Joanna Warren, Thomas Wekerle, Mario Wiletel, Nina Pilat, Romy Steiner, Theresa M. Corpuz, Jonathan Sprent, Kylie E. Webster, Anna M. Weijler, Benedikt Mahr
Publikováno v:
Proc Natl Acad Sci U S A
Injection of Interleukin-2 (IL-2) complexed with a particular anti–IL-2 monoclonal antibody (mab) JES6-1 has been shown to selectively expand CD4(+)Foxp3(+) T regulatory T cells (Tregs) in vivo. Although the potency of this approach with regard to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbfa9d129b4432a3ff2026f0bbd9d7c
https://doi.org/10.1073/pnas.1903165116
https://doi.org/10.1073/pnas.1903165116