Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Romy Böttcher"'
Autor:
Lukas Häselbarth, Sara Gamali, Domenica Saul, Manuela Krumbholz, Romy Böttcher-Loschinski, Martin Böttcher, Deyu Zou, Markus Metzler, Axel Karow, Dimitrios Mougiakakos
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Chronic myeloid leukemia (CML) is effectively treated with tyrosine kinase inhibitors (TKIs), targeting the BCR::ABL1 oncoprotein. Still, resistance to therapy, relapse after treatment discontinuation, and side effects remain significant iss
Externí odkaz:
https://doaj.org/article/21d4649d4b6548ffaf9e27d12209e88a
Autor:
Regina Jitschin, Simon Völkl, Andreas Mackensen, Dimitrios Mougiakakos, Andreas Gießl, Heiko Bruns, Martin Böttcher, Rebecca Baur, Andrej Stoll, Thomas Fischer, Franziska Karl, Romy Böttcher-Loschinski, Cindy Flamann, Ursula Schlötzer-Schrehardt, Denis M Schewe
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for a number of hemato-oncological disorders. In fact, allo-HSCT is considered as one of the most successful immunotherapies as its clinical
Externí odkaz:
https://doaj.org/article/03f44df1f3a242ae85281eb8bc2b8891
Autor:
Nouria Jantz-Naeem, Romy Böttcher-Loschinski, Katrin Borucki, Marisa Mitchell-Flack, Martin Böttcher, Burkhart Schraven, Dimitrios Mougiakakos, Sascha Kahlfuss
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
One of the key challenges for successful cancer therapy is the capacity of tumors to evade immune surveillance. Tumor immune evasion can be accomplished through the induction of T cell exhaustion via the activation of various immune checkpoint molecu
Externí odkaz:
https://doaj.org/article/9166a3fa89514680929662af73b2b1da
Autor:
Romy Böttcher-Loschinski, Judit Rial Saborido, Martin Böttcher, Sascha Kahlfuss, Dimitrios Mougiakakos
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1182 (2022)
Nowadays, T-cell-based approaches play an increasing role in cancer treatment. In particular, the use of (genetically engineered) T-cells has heralded a novel era for various diseases with previously poor outcomes. Concurrently, the relationship betw
Externí odkaz:
https://doaj.org/article/7b9575556b174047b0c24c7fd5cbbfe6
Autor:
Martin Böttcher, Romy Böttcher-Loschinski, Sascha Kahlfuss, Michael Aigner, Andreas Gießl, Andreas Mackensen, Ursula Schlötzer-Schrehardt, Thomas Tüting, Heiko Bruns, Dimitrios Mougiakakos
Publikováno v:
Cells, Vol 11, Iss 14, p 2176 (2022)
Background: Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of malignant B-cells and multiple immune defects. This leads, among others, to severe infectious complications and inefficient immune surveillance. T-cell deficie
Externí odkaz:
https://doaj.org/article/30b729fc4d4b46c69f758cf5fa7373b5
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1777-1785 (2016)
Custom genome editing has become an essential element of molecular biology. In particular, the generation of fusion constructs with epitope tags or fluorescent proteins at the genomic locus facilitates the analysis of protein expression, localization
Externí odkaz:
https://doaj.org/article/1e1a711b97e4454cb1573ec03f34a3dc
Autor:
Karin Merk, Marco Breinig, Romy Böttcher, Stefan Krebs, Helmut Blum, Michael Boutros, Klaus Förstemann
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006861 (2017)
DNA double-strand breaks trigger the production of locus-derived siRNAs in fruit flies, human cells and plants. At least in flies, their biogenesis depends on active transcription running towards the break. Since siRNAs derive from a double-stranded
Externí odkaz:
https://doaj.org/article/c07b208667264bd0bb000667f5c6cb38
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
DNA double-strand breaks are among the most toxic lesions that can occur in a genome and their faithful repair is thus of great importance. Recent findings have uncovered local transcription that initiates at the break and forms a non-coding transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e5943ab0a31e3e261791869dd9048d
https://doi.org/10.1080/15476286.2021.2014694
https://doi.org/10.1080/15476286.2021.2014694
Autor:
Andreas Hutloff, Sebastian Drube, Sylvia Müller, Philine Wegner, Romy Böttcher-Loschinski, Nico Andreas, Thomas Kamradt, Franziska Weber, Matthias Gaestel
Publikováno v:
Immunology
Summary IL‐33 is a member of the IL‐1 family. By binding to its receptor ST2 (IL‐33R) on mast cells, IL‐33 induces the MyD88‐dependent activation of the TAK1‐IKK2 signalling module resulting in activation of the MAP kinases p38, JNK1/2 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f2e053b1fe95c70c232db6cde2310b
http://europepmc.org/articles/PMC8044339
http://europepmc.org/articles/PMC8044339
Autor:
Rebecca Baur, Franziska Karl, Romy Böttcher-Loschinski, Andrej Stoll, Simon Völkl, Andreas Gießl, Cindy Flamann, Heiko Bruns, Ursula Schlötzer-Schrehardt, Martin Böttcher, Denis M Schewe, Thomas Fischer, Regina Jitschin, Andreas Mackensen, Dimitrios Mougiakakos
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e006362
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for a number of hemato-oncological disorders. In fact, allo-HSCT is considered as one of the most successful immunotherapies as its clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6548b8721cf5c5ce250b843b4ff328e5
https://doi.org/10.1136/jitc-2022-006362
https://doi.org/10.1136/jitc-2022-006362