Výsledky vyhledávání - "Romolo A. Gambetta"

Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative

Autor: Marco A. Pierotti, Cinzia Lanzi, Tiziana Pensa, Ernesto Menta, Romolo A. Gambetta, Maria Grazia Borrello, Franco Zunino, Giuliana Cassinelli, Marco Cassinis

Publikováno v: International Journal of Cancer. 85:384-390

ret-derived oncogenes are frequently and specifically expressed in thyroid tumors. In contrast to the ret receptor, ret oncoproteins are characterized by ligand-independent tyrosine-kinase activity and tyrosine phosphorylation. In this study, novel s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff64922d21cdf6c9e0a8758ebf7819a
https://doi.org/10.1002/(sici)1097-0215(20000201)85:3<384::aid-ijc15>3.0.co

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Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes

Autor: Rosanna Supino, Elena Mapelli, Romolo A. Gambetta, Elena Sala, Marialuisa Sensi, P. Banfi, Franco Zunino

Publikováno v: International Journal of Cancer. 57:281-286

The involvement of protein kinase C (PKC) in the mechanism of chemotaxis and invasiveness of human melanoma has been studied in 6 clones of 665/2 cell line characterized by a different integrin profile, differentiation grade and in vitro invasive abi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fb6e1c9c91b63f6c310e786a8a8299
https://doi.org/10.1002/ijc.2910570225

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A study of cross-resistance pattern and expression of molecular markers of multidrug resistance in a human small-cell lung-cancer cell line selected with doxorubicin

Autor: Monica Binaschi, Rosanna Supino, Franco Zunino, Giovanni Capranico, Ennio Prosperi, E. Sala, Romolo A. Gambetta

Publikováno v: International Journal of Cancer. 54:309-314

A doxorubicin-resistant variant of the human small-cell lung-cancer cell line N592 was selected by in vitro continuous exposure to increasing drug concentrations. The aim of this study was to examine the cross-resistance pattern, cellular pharmacokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041e691c8c69def97f0df2ee5428e644
https://doi.org/10.1002/ijc.2910540224

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Protein kinase C activation by anthracyclines in swiss 3T3 cells

Autor: Romolo A. Gambetta, P. Banfi, Lorena Guazzoni, Franco Zunino, Aimarita Franzi, Cinzia Lanzi, Paola Perego

Publikováno v: International Journal of Cancer. 47:136-142

The effects of the anti-cancer anthracyclines doxorubicin and daunorubicin on the activity of protein kinase C (PKC) were examined in intact Swiss 3T3 cells. The 2 drugs stimulated the phosphorylation of an 80K phosphoprotein found to be identical to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f666ae877fae2706a531d4910add4d
https://doi.org/10.1002/ijc.2910470124

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Downexpression of aldehyde dehydrogenase 1 in murine lung tumors

Autor: Giacomo Manenti, Tommaso A. Dragani, Marco A. Pierotti, F. Stefania Falvella, Romolo A. Gambetta

Publikováno v: Molecular Carcinogenesis. 16:123-125

We analyzed the expression of the cytosolic aldehyde dehydrogenase 1 (Aldh1) gene in mouse lung tumors by northern blotting and immunocytochemical analysis. Aldh1 was abundantly expressed in normal lung tissue, with a predominant cellular localizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d6597752c9f3bddf0657b24c11709e5
https://doi.org/10.1002/(sici)1098-2744(199607)16:3<123::aid-mc1>3.0.co

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Clavilactones, a novel class of tyrosine kinase inhibitors of fungal origin

Autor: Graziella Pratesi, Gianluca Nasini, Giuditta Cuccuru, Giuliana Cassinelli, Romolo A. Gambetta, Franco Zunino, Cinzia Lanzi, Monica Tortoreto, Marco Cassinis, Tiziana Pensa, Donatella Polizzi

Publikováno v: Biochemical pharmacology. 59(12)

Targeting of deregulated protein tyrosine kinases has been proposed as a new approach in the therapeutic intervention against pathological processes including proliferative disorders and cancer. Using a screening approach based on a comparative evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2736196e0f5b525be1a431441c40ab
https://pubmed.ncbi.nlm.nih.gov/10799650

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Decreased drug accmulation and increased tolerance to DNA damage in tumor cells with a low level of cisplatin resistance

Autor: Romolo A. Gambetta, Tiziana Pensa, I. Viano, Rosanna Supino, Franco Zunino, P Apostoli, Giuliana Cassinelli, Nives Carenini, Simona Romanelli, Paola Perego, Donato Colangelo, Roberto Leone, Cinzia Lanzi

In an attempt to examine the cellular changes associated with cisplatin resistance, we selected a cisplatin-resistant (A431/Pt) human cervix squamous cell carcinoma cell line following continuous in vitro drug exposure. The resistant subline was char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441f4bfa800dc320afef3d49175a2028
http://hdl.handle.net/11379/34794

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Synthesis of alkyl chain-modified ether lipids and evaluation of their in vitro cytotoxicity

Autor: Romolo A. Gambetta, Nuria Suesa, Cinta Lobato, Liset Borras, Patrizia Banfi, Empar Fos, David Mauleón, Germano Carganico, Franco Zunino

Publikováno v: Journal of medicinal chemistry. 38(7)

A series of alkyl lysophospholipid (ALP) analogs of ET-18-OCH 3 (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) containing modifications in the long C-1 chain has been synthesized and evaluated in human tumor cell line cytotoxicity assays. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99eb1549912629baf23f749370406a71
https://pubmed.ncbi.nlm.nih.gov/7707324

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Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells

Autor: Franco Zunino, Romolo A. Gambetta, Carla Soranzo, Greta Casati, Paola Perego

Publikováno v: Cancer letters. 72(1-2)

The effect of modulation of protein kinase C (PKC) activity by 12- O -tetradecanoylphorbol-13-acetate (TPA) on cisplatin cytotoxicity was examined in a human osteosarcoma U2-OS cell line and in a U2-OS variant (U2-OS/Pt) selected after continuous exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27acc693994cc216fbb908dcd502cecf
https://pubmed.ncbi.nlm.nih.gov/8402575

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Lipid peroxidation, phosphoinositide turnover and protein kinase C activation in human platelets treated with anthracyclines and their complexes with Fe(III)

Autor: Ornella Parolini, Romolo A. Gambetta, P. Banfi, Cinzia Lanzi

The effects of the antitumor drugs daunorubicin, doxorubicin and their complexes with Fe(III) on phosphoinositide hydrolysis, lipid peroxidation and protein kinase C (PKC) activation were measured in intact human platelets. Doxorubicin and the Fe(III

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f147c5c9eff8a38f13eb4e7360dd0a
http://hdl.handle.net/10807/92574

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