Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Romina Vuono"'
Autor:
William R Webb, Gauri Thapa, Alice Tirnoveanu, Sabrina Kallu, Charlene Loo Jin Yi, Nirali Shah, Joseph Macari, Sadie Mitchell, Graham J Fagg, Rachael N Jeremiah, Sandiya Theminimulle, Romina Vuono, Athina Mylona
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0269883 (2022)
Coronavirus Disease 19 (COVID-19) caused by the SARS-CoV-2 virus remains a global pandemic having a serious impact on national economies and healthcare infrastructure. Accurate infection detection protocols are key to policy guidance and decision mak
Externí odkaz:
https://doaj.org/article/272a132094874a3ca7c95c1cd5881230
Autor:
Karolina Pircs, Rebecca Petri, Sofia Madsen, Per Ludvik Brattås, Romina Vuono, Daniella R. Ottosson, Isabelle St-Amour, Bob A. Hersbach, Monika Matusiak-Brückner, Sofia Hult Lundh, Åsa Petersén, Nicole Déglon, Sébastien S. Hébert, Malin Parmar, Roger A. Barker, Johan Jakobsson
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1397-1406 (2018)
Summary: Many neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences of impaired autophagy for neuronal function remain poorly understood. In
Externí odkaz:
https://doaj.org/article/aa4ff126368d4f88950180d6f7fe4264
Autor:
Alba Di Pardo, Enrico Amico, Abdul Basit, Andrea Armirotti, Piyush Joshi, M. Diana Neely, Romina Vuono, Salvatore Castaldo, Anna F. Digilio, Francesco Scalabrì, Giuseppe Pepe, Francesca Elifani, Michele Madonna, Se Kyoo Jeong, Bu-Mahn Park, Maurizio D’Esposito, Aaron B. Bowman, Roger A. Barker, Vittorio Maglione
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Huntington’s disease is characterized by a complex and heterogeneous pathogenic profile. Studies have shown that disturbance in lipid homeostasis may represent a critical determinant in the progression of several neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/bf0f9516edd7471585e05c6cc1d03c10
Autor:
Janelle Drouin‐Ouellet, Shong Lau, Per Ludvik Brattås, Daniella Rylander Ottosson, Karolina Pircs, Daniela A Grassi, Lucy M Collins, Romina Vuono, Annika Andersson Sjöland, Gunilla Westergren‐Thorsson, Caroline Graff, Lennart Minthon, Håkan Toresson, Roger A Barker, Johan Jakobsson, Malin Parmar
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1117-1131 (2017)
Abstract Direct conversion of human fibroblasts into mature and functional neurons, termed induced neurons (iNs), was achieved for the first time 6 years ago. This technology offers a promising shortcut for obtaining patient‐ and disease‐specific
Externí odkaz:
https://doaj.org/article/e73f830423c14f13b05bd7371e571788
Autor:
Diogo Ribeiro, Rocio Laguna Goya, Geeta Ravindran, Romina Vuono, Clare L. Parish, Claire Foldi, Tobias Piroth, Shanzheng Yang, Malin Parmar, Guido Nikkhah, Jens Hjerling-Leffler, Olle Lindvall, Roger A. Barker, Ernest Arenas
Publikováno v:
Neurobiology of Disease, Vol 49, Iss , Pp 118-127 (2013)
Human fetal midbrain tissue grafting has provided proof-of-concept for dopamine cell replacement therapy (CRT) in Parkinson's disease (PD). However, limited tissue availability has hindered the development and widespread use of this experimental ther
Externí odkaz:
https://doaj.org/article/d0ca47ad791e4b7593f54de6cd698c47
Autor:
Karolina Pircs, Janelle Drouin-Ouellet, Vivien Horváth, Jeovanis Gil, Melinda Rezeli, Raquel Garza, Daniela A Grassi, Yogita Sharma, Isabelle St-Amour, Kate Harris, Marie E Jönsson, Pia A Johansson, Romina Vuono, Shaline V Fazal, Thomas Stoker, Bob A Hersbach, Kritika Sharma, Jessica Lagerwall, Stina Lagerström, Petter Storm, Sébastien S Hébert, György Marko-Varga, Malin Parmar, Roger A Barker, Johan Jakobsson
Huntington's disease is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in ageing humans. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667921ae8a7da270bf48986c499fbc03
https://www.repository.cam.ac.uk/handle/1810/332257
https://www.repository.cam.ac.uk/handle/1810/332257
Autor:
William R. Webb, Gauri Thapa, Alice Tirnoveanu, Sabrina Kallu, Charlene Loo Jin Yi, Nirali Shah, Joseph Macari, Sadie Mitchell, Graham J. Fagg, Rachael N. Jeremiah, Sandiya Theminimulle, Romina Vuono, Athina Mylona
Publikováno v:
PloS one. 17(7)
Coronavirus Disease 19 (COVID-19) caused by the SARS-CoV-2 virus remains a global pandemic having a serious impact on national economies and healthcare infrastructure. Accurate infection detection protocols are key to policy guidance and decision mak
Autor:
Dario Besusso, Dan Felsenfeld, Valeria Ranzani, Raoul J. P. Bonnal, Samantha A. Morris, Elena Cattaneo, Massimiliano Pagani, Romina Vuono, Andrea Faedo, Paola Conforti, Marco De Simone, Roger A. Barker, Federica Gervasoni, Elena Vezzoli, Tiziana Lischetti, Xiaoling He, Maura Galimberti, Grazisa Rossetti, Vittoria Dickinson Bocchi, Jian Chen, Giulio Pavesi, Claudio Cappadona, Kenji Kamimoto, Ira Espuny-Camacho
Publikováno v:
Science
Deciphering how the human striatum develops is necessary for understanding the diseases that affect this region. To decode the transcriptional modules that regulate this structure during development, we compiled a catalog of 1116 long intergenic nonc
Autor:
Elizabeth Jones, Anthony J. Holland, Anastasia Bickerton, Romina Vuono, Ruma Raha-Chowdhury, Shahid Zaman, Animesh Alexander Raha, James Henderson, Robert Fincham, Kieren Allinson
Publikováno v:
Journal of Alzheimer's Disease
Background Genetic factors that influence Alzheimer's disease (AD) risk include mutations in TREM2 and allelic variants of Apolipoprotein E, influencing AD pathology in the general population and in Down syndrome (DS). Evidence shows that dysfunction
Autor:
Romina Vuono, Marcella Birtele, Janelle Drouin-Ouellet, Petter Storm, Fredrik Nilsson, Roger A. Barker, Yogita Sharma, Shelby Shrigley, Malin Parmar, Maria Pereira, Thomas B Stoker, Emilie M. Legault, Karolina Pircs, Johan Jakobsson
Understanding the pathophysiology of Parkinson’s disease has been hampered by the lack of models that recapitulate all the critical factors underlying its development. Here, we generated functional induced dopaminergic neurons (iDANs) that were dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302821c5210820579a5202cdd78459e0
https://doi.org/10.1101/2021.04.23.441070
https://doi.org/10.1101/2021.04.23.441070