Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation

Autor: Hai Yu, Ulf Hellman, Romina P. Muiá, Carolyn R. Bertozzi, Jennifer A. Prescher, Oscar Campetella, Xi Chen

Publikováno v: Glycobiology. 20:833-842

Trypanosoma cruzi, the agent of the American trypanosomiasis or Chagas disease, bypasses its lack of de novo synthesis of sialic acids by expressing a surface-anchored trans-sialidase. This enzyme transfers sialic acid residues from the host's sialyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e3b56589f1e8b8019df0812f1d6756
https://doi.org/10.1093/glycob/cwq037

Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors

Autor: Juan Mucci, Tamara A. Pitcovsky, Alejandro Buschiazzo, Romina P. Muiá, Oscar Campetella, Nicole Larrieux

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2012, 8 (1), pp.e1002474. ⟨10.1371/journal.ppat.1002474⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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PLoS Pathogens, 2012, 8 (1), pp.e1002474. ⟨10.1371/journal.ppat.1002474⟩
PLoS Pathogens, Vol 8, Iss 1, p e1002474 (2012)

Trans-sialidase (TS), a virulence factor from Trypanosoma cruzi, is an enzyme playing key roles in the biology of this protozoan parasite. Absent from the mammalian host, it constitutes a potential target for the development of novel chemotherapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dd9fb2da1a6d112eed5ba08cb3a121
https://hal-riip.archives-ouvertes.fr/pasteur-00686326/file/journal.ppat.1002474.pdf