Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Romina Lessene"'
Autor:
Mark F. van Delft, Meng Xiao Luo, Kate McArthur, Peter E. Czabotar, Jarrod J. Sandow, Laura F. Dagley, Kym N Lowes, Jason M. Brouwer, Andrew I. Webb, Guillaume Lessene, Rachael M. Lane, Keith G. Watson, Christoph Grohmann, Ahmad Wardak, Peter M. Colman, Sabrina Bernard, Soo San Wan, Yelena Khakham, Phillip P. Sharp, Romina Lessene, Thao Nguyen, David J. Segal, David C.S. Huang, Erinna F. Lee, Lucy Li, Marlyse A. Debrincat, Grant Dewson, Chinh T. Bui, Hui San Chin, W. Douglas Fairlie, Stephane Duflocq, Benjamin T. Kile, Stephane Chappaz, Caroline Miles, Kurt Lackovic, Laure Peilleron
Publikováno v:
Nature Chemical Biology. 15:1057-1066
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f8a84e9d19f8763b3963c4941664e3
https://doi.org/10.1038/s41589-019-0365-8
https://doi.org/10.1038/s41589-019-0365-8
Autor:
Mark F, van Delft, Stephane, Chappaz, Yelena, Khakham, Chinh T, Bui, Marlyse A, Debrincat, Kym N, Lowes, Jason M, Brouwer, Christoph, Grohmann, Phillip P, Sharp, Laura F, Dagley, Lucy, Li, Kate, McArthur, Meng-Xiao, Luo, Hui San, Chin, W Douglas, Fairlie, Erinna F, Lee, David, Segal, Stephane, Duflocq, Romina, Lessene, Sabrina, Bernard, Laure, Peilleron, Thao, Nguyen, Caroline, Miles, Soo San, Wan, Rachael M, Lane, Ahmad, Wardak, Kurt, Lackovic, Peter M, Colman, Jarrod J, Sandow, Andrew I, Webb, Peter E, Czabotar, Grant, Dewson, Keith G, Watson, David C S, Huang, Guillaume, Lessene, Benjamin T, Kile
Publikováno v:
Nature chemical biology. 15(11)
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0477b40e4e5384654fad1f5b446d351b
https://pubmed.ncbi.nlm.nih.gov/31591564
https://pubmed.ncbi.nlm.nih.gov/31591564
Autor:
Christopher J.H. Porter, Brian Kelly, Guy Y. Krippner, Benjamin James Boyd, Lisa M. Kaminskas, Romina Lessene, Peter Karellas
Publikováno v:
Molecular Pharmaceutics. 5:449-463
The impact of PEGylation on the pharmacokinetics and biodistribution of (3)H-labeled poly l-lysine dendrimers has been investigated after intravenous administration to rats. The volumes of distribution, clearance and consequently the plasma half-live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30d44e4890a3802013607b972999742
https://doi.org/10.1021/mp7001208
https://doi.org/10.1021/mp7001208
Autor:
Christopher J.H. Porter, Guy Y. Krippner, Peter Karellas, Benjamin James Boyd, Lisa M. Kaminskas, Romina Lessene
Publikováno v:
Molecular Pharmaceutics. 3:614-627
Cationic poly-L-lysine 3H-dendrimers with either 16 or 32 surface amine groups (BHALys [Lys]4 [3H-Lys]8 [NH2]16 and BHALys [Lys]8 [3H-Lys]16 [NH2]32, generation 3 and 4, respectively) have been synthesized and their pharmacokinetics and biodistributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7fce195265e05e12e1e24185d42663
https://doi.org/10.1021/mp060032e
https://doi.org/10.1021/mp060032e
Autor:
I. Holmes, Melanie deSilva, Ian P. Street, M.C. Chung, David J. Curtis, Stupple Paul Anthony, Julian Grusovin, Danny Ganame, Richard C. Foitzik, Alison Thistlethwaite, Romina Lessene, Gill E. Lunniss, Stephen M. Jane, Brendon J. Monahan, Elizabeth Allan, Michelle Ang Camerino, Hong Yang, Ylva E. Bozikis, Karen L. White, Rachel Lagiakos, Alexandra E. Stupple, S.J. Hermans, Marica Nikac, Scott Raymond Walker, Wilhelmus J A Kersten, Thomas S. Peat, Ben Morrow, Emma Toulmin, Hendrik Falk, Stefan Eugen Sonderegger, Michael W. Parker, Susan A. Charman, Jo-Anne Pinson, Patricia A. Pilling
Publikováno v:
Cancer Research. 75:5371-5371
Increased expression or dysregulation of protein arginine methyltransferase 5 (PRMT5) activity is associated with poor prognosis in many cancers. Through increased methylation of epigenetic and non-epigenetic targets, the aberrant activity of PRMT5 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8c8cb45e89f0255f68906d2972ced15
https://doi.org/10.1158/1538-7445.am2015-5371
https://doi.org/10.1158/1538-7445.am2015-5371
Autor:
Marica Nikac, Clare L. Scott, Romina Lessene, Ian P. Street, Wilhelmus J A Kersten, Scott E. Walker, Ylva Elisabet Bergman, Kurt Lackovic, C Robinson, Grant A. McArthur, Danny Ganame, M de Sylva, Robin L. Anderson, G. Holloway, Michelle Ang Camerino, Michael W. Parker, M Gorman, Brendon J. Monahan, Anthony Natoli, Alison Gregg, Susan A. Charman, I. Holmes, Karl-Johan Leuchowius, G Lovrecz, Neil Choi, Gillian Elizabeth Lunniss, Catherine Fae Hemley, Hannah P. Yang, Judy Doherty, Richard C. Foitzik, Mark G. Devlin, P Novello, Hendrik Falk, Thomas S. Peat
Publikováno v:
Cancer Research. 72:LB-308
Background: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that provides a critical hub for signalling from at least four different classes of cellular sensing mechanisms including growth factor receptors, GPCRs, integrins and mechanic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::316d8cafedec83d9505527a632196c10
https://doi.org/10.1158/1538-7445.am2012-lb-308
https://doi.org/10.1158/1538-7445.am2012-lb-308