Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Romina J. Bevacqua"'
Autor:
Romina J. Bevacqua, Weichen Zhao, Emilio Merheb, Seung Hyun Kim, Alexander Marson, Anna L. Gloyn, Seung K. Kim
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108693- (2024)
Summary: Successful genome editing in primary human islets could reveal features of the genetic regulatory landscape underlying β cell function and diabetes risk. Here, we describe a CRISPR-based strategy to interrogate functions of predicted regula
Externí odkaz:
https://doaj.org/article/de99b45ae5104da68c614e2231a5ccff
Autor:
Romina J. Bevacqua, Xiaoqing Dai, Jonathan Y. Lam, Xueying Gu, Mollie S. H. Friedlander, Krissie Tellez, Irene Miguel-Escalada, Silvia Bonàs-Guarch, Goutham Atla, Weichen Zhao, Seung Hyun Kim, Antonia A. Dominguez, Lei S. Qi, Jorge Ferrer, Patrick E. MacDonald, Seung K. Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The editing of primary human islets could provide insight into diabetes pathogenesis. Here the authors use CRISPR-Cas9 to target regulatory elements associated with T2D susceptibility.
Externí odkaz:
https://doaj.org/article/22d2b0339efc4aa29c30bb51db113c85
Autor:
Mollie F. Qian, Romina J. Bevacqua, Vy M. Nguyen, Xiong Liu, Weichen Zhao, Charles A. Chang, Xueying Gu, Xiao-Qing Dai, Patrick E. MacDonald, Seung K. Kim
HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes (HNF1A-MODY) and hypomorphic HNF1A variants confer type 2 diabetes risk, but a lack of experimental systems has limited our understanding of how the transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::150dd0081f15cabf5b5a1b1b9a77a28a
https://doi.org/10.1101/2022.09.25.509394
https://doi.org/10.1101/2022.09.25.509394
Autor:
Robert L. Whitener, Seung K. Kim, Mollie S.H. Friedlander, Romina J. Bevacqua, Jonathan Y. Lam, Xueying Gu, Heshan Peiris, Seokho Kim
Publikováno v:
Genes Dev
The physiological functions of many vital tissues and organs continue to mature after birth, but the genetic mechanisms governing this postnatal maturation remain an unsolved mystery. Human pancreatic β-cells produce and secrete insulin in response
Autor:
Daniel Ebner, Romina J. Bevacqua, Agata Wesolowska-Andersen, Sameena Nawaz, Anna L. Gloyn, Seokho Kim, Baronio R, Elena Navarro-Guerrero, Rajesh, Antje Grotz, Soren K. Thomsen
Identification of the genes and processes mediating genetic association signals for complex disease represents a major challenge. Since many of the genetic signals for type 2 diabetes exert their effects through pancreatic islet-cell dysfunction, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50361baae7089b419cb765f677471d1d
https://doi.org/10.1101/2021.05.28.445984
https://doi.org/10.1101/2021.05.28.445984
Autor:
Antje K. Rottner, Yingying Ye, Elena Navarro-Guerrero, Varsha Rajesh, Alina Pollner, Romina J. Bevacqua, Jing Yang, Aliya F. Spigelman, Roberta Baronio, Austin Bautista, Soren K. Thomsen, James Lyon, Sameena Nawaz, Nancy Smith, Agata Wesolowska-Andersen, Jocelyn E. Manning Fox, Han Sun, Seung K. Kim, Daniel Ebner, Patrick E. MacDonald, Anna L. Gloyn
Publikováno v:
Nature genetics.
Identification of the genes and processes mediating genetic association signals for complex diseases represents a major challenge. As many of the genetic signals for type 2 diabetes (T2D) exert their effects through pancreatic islet-cell dysfunction,
Publikováno v:
Diabetes
Pancreatic islets are vital endocrine regulators of systemic metabolism, and recent investigations have increasingly focused on understanding human islet biology. Studies of isolated human islets have advanced understanding of the development, functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888047e06d850c7cf488a2831f117a4f
https://doi.org/10.2337/figshare.14075618.v1
https://doi.org/10.2337/figshare.14075618.v1
Autor:
Peter K. Jackson, Peter V. Lidsky, Matthias S. Matter, Bokai Zhu, Anna K. Stalder, Yinghong Xiao, Jayakar V. Nayak, Garry P. Nolan, Raul Andino, Ivan T. Lee, Sizun Jiang, Yury Goltsev, Chien-Ting Wu, Han Chen, Romina J. Bevacqua, Robert L. Whitener, Janos Demeter, Charles A. Chang, Ran Cheng, Tsuguhisa Nakayama, Alexandar Tzankov
Publikováno v:
Cell Metabolism
Cell metabolism, vol 33, iss 8
Cell metabolism, vol 33, iss 8
Emerging evidence points toward an intricate relationship between the pandemic of coronavirus disease 2019 (COVID-19) and diabetes. While preexisting diabetes is associated with severe COVID-19, it is unclear whether COVID-19 severity is a cause or c
Autor:
Seung K. Kim, Yan Hang, Romina J. Bevacqua, Keren I. Hilgendorf, Janos Demeter, Peter K. Jackson, Chien-Ting Wu
Publikováno v:
Genesdevelopment. 35(17-18)
Multiple G protein-coupled receptors (GPCRs) are expressed in pancreatic islet cells, but the majority have unknown functions. We observed specific GPCRs localized to primary cilia, a prominent signaling organelle, in pancreatic α and β cells. Loss
Autor:
Romina J. Bevacqua, Chien-Ting Wu, Keren I. Hilgendorf, Seung K. Kim, Peter K. Jackson, Yan Hang, Janos Demeter
SummaryMultiple G protein coupled receptors (GPCRs) are expressed in pancreatic islet cells but the majority have unknown functions. We observe specific GPCRs localized to primary cilia, a prominent signaling organelle, in pancreatic α- and β-cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f372fb0f539026ff13b49b0cce865b
https://doi.org/10.1101/2020.10.21.349423
https://doi.org/10.1101/2020.10.21.349423