Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Romina Burla"'
Publikováno v:
Cells, Vol 13, Iss 15, p 1307 (2024)
The endosomal sorting complex required for transport (ESCRT) machinery is composed of an articulated architecture of proteins that assemble at multiple cellular sites. The ESCRT machinery is involved in pathways that are pivotal for the physiology of
Externí odkaz:
https://doaj.org/article/4ecb304ca88d40a5a9e0e10e33ef0165
Autor:
Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla, Isabella Saggio
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-17 (2022)
Abstract Background Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated. AKTIP is a telomeric protein with the property of being enriched at the nucle
Externí odkaz:
https://doaj.org/article/094aad5334ef43d49206cb25055b6444
Autor:
Romina Burla, Mattia La Torre, Klizia Maccaroni, Fiammetta Verni, Simona Giunta, Isabella Saggio
Publikováno v:
Nucleus, Vol 11, Iss 1, Pp 205-218 (2020)
The nuclear envelope compartmentalizes chromatin in eukaryotic cells. The main nuclear envelope components are lamins that associate with a panoply of factors, including the LEM domain proteins. The nuclear envelope of mammalian cells opens up during
Externí odkaz:
https://doaj.org/article/2dc94556ae0849ad9b057a4d4474d3b7
AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.
Autor:
Chiara Merigliano, Romina Burla, Mattia La Torre, Simona Del Giudice, Hsiangling Teo, Chong Wai Liew, Alexandre Chojnowski, Wah Ing Goh, Yolanda Olmos, Klizia Maccaroni, Maria Giubettini, Irene Chiolo, Jeremy G Carlton, Domenico Raimondo, Fiammetta Vernì, Colin L Stewart, Daniela Rhodes, Graham D Wright, Brian E Burke, Isabella Saggio
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009757 (2021)
To complete mitosis, the bridge that links the two daughter cells needs to be cleaved. This step is carried out by the endosomal sorting complex required for transport (ESCRT) machinery. AKTIP, a protein discovered to be associated with telomeres and
Externí odkaz:
https://doaj.org/article/bc66149e25c047faa2127e3e143af22e
Publikováno v:
Cells, Vol 11, Iss 11, p 1749 (2022)
Membrane-enclosed organelle compartmentalization is not the only way by which cell processes are spatially organized. Phase separation is emerging as a new driver in the organization of membrane-less compartments and biological processes. Liquid–li
Externí odkaz:
https://doaj.org/article/400b10ffba5c47f5811a6f18245a20bc
Autor:
Domenico Raimondo, Cristina Remoli, Letizia Astrologo, Romina Burla, Mattia La Torre, Fiammetta Vernì, Enrico Tagliafico, Alessandro Corsi, Simona Del Giudice, Agnese Persichetti, Giuseppe Giannicola, Pamela G Robey, Mara Riminucci, Isabella Saggio
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227279 (2020)
Fibrous dysplasia (FD) of bone is a complex disease of the skeleton caused by dominant activating mutations of the GNAS locus encoding for the α subunit of the G protein-coupled receptor complex (Gsα). The mutation involves a substitution of argini
Externí odkaz:
https://doaj.org/article/3a90d042f58b441d85095eb0b8837932
Autor:
Romina Burla, Mattia La Torre, Giorgia Zanetti, Alex Bastianelli, Chiara Merigliano, Simona Del Giudice, Alessandro Vercelli, Ferdinando Di Cunto, Marina Boido, Fiammetta Vernì, Isabella Saggio
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practica
Externí odkaz:
https://doaj.org/article/2d529d953eb344e79f1020c24bcf3ea6
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, works as cofactor in numerous enzymatic reactions and it behaves as antioxidant molecule. PLP deficiency has been associated to many human pathologies including cancer and diabetes and th
Externí odkaz:
https://doaj.org/article/c477b98d6169496eb87e9d846d91a14a
Autor:
Romina Burla, Mariateresa Carcuro, Mattia La Torre, Federica Fratini, Marco Crescenzi, Maria Rosaria D'Apice, Paola Spitalieri, Grazia Daniela Raffa, Letizia Astrologo, Giovanna Lattanzi, Enrico Cundari, Domenico Raimondo, Annamaria Biroccio, Maurizio Gatti, Isabella Saggio
Publikováno v:
Open Biology, Vol 6, Iss 8 (2016)
AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes
Externí odkaz:
https://doaj.org/article/5668c6ab1b8a473bb48cc05f38249c18
Autor:
Romina Burla, Mariateresa Carcuro, Grazia D Raffa, Alessandra Galati, Domenico Raimondo, Angela Rizzo, Mattia La Torre, Emanuela Micheli, Laura Ciapponi, Giovanni Cenci, Enrico Cundari, Antonio Musio, Annamaria Biroccio, Stefano Cacchione, Maurizio Gatti, Isabella Saggio
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005167 (2015)
Telomeres are nucleoprotein complexes that protect the ends of linear chromosomes from incomplete replication, degradation and detection as DNA breaks. Mammalian telomeres are protected by shelterin, a multiprotein complex that binds the TTAGGG telom
Externí odkaz:
https://doaj.org/article/ec2e1ff22daf46b2bdc27d8bf028cd96