Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.

Autor: Ebenhoch R; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Bauer M; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Romig H; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Gottschling D; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Kley JT; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Heine N; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Weber A; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Uphues I; Cardiometabolic Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Nar H; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Pautsch A; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany.

Publikováno v: Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2023 Oct 01; Vol. 79 (Pt 10), pp. 871-880. Date of Electronic Publication: 2023 Sep 15.

Discussions: Early History of Division by Zero

Autor: Romig, H. G.

Publikováno v: The American Mathematical Monthly, 1924 Oct 01. 31(8), 387-389.

Externí odkaz: https://www.jstor.org/stable/2298825

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

Autor: Kulic, L, Walter, J, Multhaup, G, Teplow, DB, Baumeister, R, Romig, H, Capell, A, Steiner, H, Haass, C

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 97, iss 11

Most of the genetically inherited Alzheimer's disease cases are caused by mutations in the presenilin genes, PS1 and PS2. PS mutations result in the enhanced production of the highly amyloidogenic 42/43 amino acid variant of amyloid beta-peptide (Abe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0f23a3daf72625d116b253b85c9db8ea
https://escholarship.org/uc/item/7hs882q5

Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.

Autor: Kuttruff CA; Medicinal Chemistry, Drug Discovery Sciences, and Immunology & Respiratory, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riss, Germany., Ferrara M; Boehringer Ingelheim Research Italia S.a.s. di BI IT S.r.l., Via G. Lorenzini 8, 20139 Milano, Italy., Bretschneider T; Medicinal Chemistry, Drug Discovery Sciences, and Immunology & Respiratory, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riss, Germany., Hoerer S; Medicinal Chemistry, Drug Discovery Sciences, and Immunology & Respiratory, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riss, Germany., Handschuh S; Medicinal Chemistry, Drug Discovery Sciences, and Immunology & Respiratory, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riss, Germany., Nosse B; Medicinal Chemistry, Drug Discovery Sciences, and Immunology & Respiratory, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riss, Germany., Romig H; Medicinal Chemistry, Drug Discovery Sciences, and Immunology & Respiratory, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riss, Germany., Nicklin P; Medicinal Chemistry, Drug Discovery Sciences, and Immunology & Respiratory, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riss, Germany., Roth GJ; Medicinal Chemistry, Drug Discovery Sciences, and Immunology & Respiratory, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riss, Germany.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Nov 08; Vol. 8 (12), pp. 1252-1257. Date of Electronic Publication: 2017 Nov 08 (Print Publication: 2017).

Importance of Sanitation for Stored-Product Pest Management.

Autor: Bingham, Georgina V.¹ (AUTHOR) gbingham@unl.edu, Hagstrum, David W.² (AUTHOR) hgstr@ksu.edu

Publikováno v: Insects (2075-4450). Jan2024, Vol. 15 Issue 1, p3. 11p.