Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Romi Ghose"'
Neratinib causes non-recoverable gut injury and reduces intestinal cytochrome P450 3A enzyme in mice
Publikováno v:
Toxicol Res (Camb)
Neratinib is a pan-HER tyrosine kinase inhibitor newly approved by FDA in 2017 to treat HER2-positive breast cancer, but the phase III trial of neratinib showed that 96% of the patients taking neratinib experienced diarrhea. So far very few mechanist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6188759f32d31b7fbf97eace2725d2c6
https://doi.org/10.1093/toxres/tfab111
https://doi.org/10.1093/toxres/tfab111
Publikováno v:
Expert Rev Vaccines
OBJECTIVE: Infectious disease emergencies like the 2013-2016 Ebola epidemic and the 2009 influenza and current SARS-CoV-2 pandemics illustrate that vaccines are now given to diverse populations with preexisting pathologies requiring pharmacological m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794304abb1791ede7fb7fa139b42d1b4
https://doi.org/10.1080/14760584.2021.1899818
https://doi.org/10.1080/14760584.2021.1899818
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 166
Irinotecan is a first-line treatment for colorectal cancer and the prodrug of 7-ethyl-10-hydroxy-camptothecin (SN-38). However, its fatal gastrointestinal (GI) toxicity raises serious concern. In liver, irinotecan generates its inactive metabolite, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d38f230a915e2145f55676d7d150ce
https://pubmed.ncbi.nlm.nih.gov/36495622
https://pubmed.ncbi.nlm.nih.gov/36495622
Publikováno v:
Expert Opin Drug Metab Toxicol
Introduction Toxicity of chemotherapy drugs is the leading cause of poor therapeutic outcome in many cancer patients. Gastrointestinal (GI) toxicity and hepatotoxicity are among the most common side effects of current chemotherapies. Emerging studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23677e05b3fd43b7349e62159031301
https://doi.org/10.1080/17425255.2020.1815705
https://doi.org/10.1080/17425255.2020.1815705
Publikováno v:
Current Opinion in Toxicology. :36-40
The importance of oxidative stress has been increasingly recognized in diabetes and related cardiovascular complications as well as in chemical-induced toxicity, which makes it a potential therapeutic target for tackling such health issues. On the ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::623dc230f0e805a95ca9a1d410b0e9eb
https://doi.org/10.1016/j.cotox.2020.04.004
https://doi.org/10.1016/j.cotox.2020.04.004
Publikováno v:
Chemico-biological interactions. 360
Irinotecan, a first-line chemotherapy for gastrointestinal (GI) cancers has been causing fatal toxicities like bloody diarrhea and steatohepatitis for years. Irinotecan goes through multiple-step drug metabolism after injection and one of its interme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9a24e81da3a5e1b97236c21d1b0b0f
https://pubmed.ncbi.nlm.nih.gov/35430260
https://pubmed.ncbi.nlm.nih.gov/35430260
Publikováno v:
Food and Chemical Toxicology. 171:113547
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82f28395ea6c6db506fc258849faa752
https://doi.org/10.1016/j.fct.2022.113547
https://doi.org/10.1016/j.fct.2022.113547
Autor:
Gabriel Tao, Romi Ghose
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0358cf2fb489c4837225be12c6f2591
https://doi.org/10.1096/fasebj.2021.35.s1.05264
https://doi.org/10.1096/fasebj.2021.35.s1.05264
Publikováno v:
Drug Metabolism and Disposition. 46:397-404
Cytochrome P450 CYP3A4 is the most abundant drug-metabolizing enzyme and is responsible for the metabolism of ∼50% of clinically available drugs. Induction of CYP3A4 impacts the disposition of its substrates and leads to harmful clinical consequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0e0961aeaa9887ce087dc42d0172ec
https://doi.org/10.1124/dmd.117.079160
https://doi.org/10.1124/dmd.117.079160
Publikováno v:
Toxicology in Vitro. 41:75-82
The bacterial receptor, Toll-like receptor (TLR) 4 mediates inflammatory responses and have been linked to a broad array of diseases. TLR4 agonists are being explored as potential treatments for cancer and other diseases. We have previously shown tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc552b72b93b46e392161b4946385fef
https://doi.org/10.1016/j.tiv.2017.02.019
https://doi.org/10.1016/j.tiv.2017.02.019