Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Romez, Uddin"'
Autor:
Clare.R. Harwood, David A. Sykes, Bradley L. Hoare, Franziska M. Heydenreich, Romez Uddin, David R. Poyner, Stephen J. Briddon, D.B. Veprintsev
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103362- (2021)
Summary: The β2-adrenoceptor (β2AR) is a well-established target in asthma and a prototypical G protein-coupled receptor for biophysical studies. Solubilization of membrane proteins has classically involved the use of detergents. However, the deter
Externí odkaz:
https://doaj.org/article/8e54c20c4bce4994832b97948f5cb7d0
Autor:
Romez Uddin, Mark Wheatley, Stephen J. Hill, Stephen J. Briddon, Leigh A. Stoddart, Joelle Goulding, David R. Poyner, Rachael L. Grime
Publikováno v:
Nanoscale. 12:11518-11525
The fundamental importance of membrane proteins in cellular processes has driven a marked increase in the use of membrane mimetic approaches for studying and exploiting these proteins. Nano-encapsulation strategies which preserve the native lipid bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c562d9b2668337cd6112eea7a6926555
https://doi.org/10.1039/d0nr01060j
https://doi.org/10.1039/d0nr01060j
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1862(7)
The use of styrene maleic acid co-polymer (SMA) for membrane protein extraction and purification has grown in recent years. SMA inserts in the membrane and assembles into small discs of bilayer encircled by polymer, termed SMA lipid particles (SMALPs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40544aa6ac2759dd72c5bf0597dad405
https://pubmed.ncbi.nlm.nih.gov/32209303
https://pubmed.ncbi.nlm.nih.gov/32209303
Autor:
Abigail Otchere, Daniel N. Wiseman, David R. Poyner, Romez Uddin, Cathy Slack, Alice Rothnie, Sarah J Routledge, Roslyn M. Bill, Jaimin H. Patel, Alan D. Goddard, Naomi L. Pollock
Publikováno v:
Protein Expression and Purification
Given their extensive role in cell signalling, GPCRs are significant drug targets; despite this, many of these receptors have limited or no available prophylaxis. Novel drug design and discovery significantly rely on structure determination, of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af1c1d1608f7785d087a40ab468c9c1
Autor:
Romez Uddin, Dmitry B. Veprintsev, Franziska M. Heydenreich, Stephen J. Briddon, Brad Hoare, David R. Poyner, Clare R. Harwood, David A. Sykes
Publikováno v:
SSRN Electronic Journal.
The β2-adrenoceptor (β2AR) is a well-established target in asthma and a prototypical GPCR for biophysical studies. Solubilisation of membrane proteins has classically involved the use of detergents. However, the detergent environment differs from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ad26e5f8443f15c369bf0fd7416ec2e
https://doi.org/10.2139/ssrn.3664363
https://doi.org/10.2139/ssrn.3664363
Autor:
Debbie L. Hay, John Simms, Michael L. Garelja, Romez Uddin, David R. Poyner, Paul W. R. Harris, Thomas P. Sakmar, Joseph J. Gingell, Margaret A. Brimble, Christopher A. Reynolds
Publikováno v:
Biochemistry. 57:4915-4922
Calcitonin gene-related peptide (CGRP) binds to the complex of the calcitonin receptor-like receptor (CLR) with receptor activity-modifying protein 1 (RAMP1). How CGRP interacts with the transmembrane domain (including the extracellular loops) of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa13a44f8849e3addb6472bfda2ec2bc
https://doi.org/10.1021/acs.biochem.8b00502
https://doi.org/10.1021/acs.biochem.8b00502
Autor:
Stephen J. Briddon, Franziska M. Heydenreich, Bradley L. Hoare, Romez Uddin, Dmitry B. Veprintsev, David R. Poyner, Clare R. Harwood, David A. Sykes
Publikováno v:
iScience
iScience, 24 (12)
iScience, Vol 24, Iss 12, Pp 103362-(2021)
iScience, 24 (12)
iScience, Vol 24, Iss 12, Pp 103362-(2021)
Summary The β2-adrenoceptor (β2AR) is a well-established target in asthma and a prototypical G protein-coupled receptor for biophysical studies. Solubilization of membrane proteins has classically involved the use of detergents. However, the deterg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289de6c7ff98ec2cb878321a29d574c9
https://doi.org/10.1016/j.isci.2021.103362
https://doi.org/10.1016/j.isci.2021.103362
Characterisation of receptors can involve either assessment of their ability to bind ligands or measure receptor activation as a result of agonist or inverse agonist interactions. This review focuses on G protein-coupled receptors (GPCRs), examining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6954797171e10614a888cc1b47e937b8
https://publications.aston.ac.uk/id/eprint/32549/1/Functional_characterisation_of_G_protein_coupled_receptors.pdf
https://publications.aston.ac.uk/id/eprint/32549/1/Functional_characterisation_of_G_protein_coupled_receptors.pdf
Publikováno v:
Handbook of experimental pharmacology. 255
The canonical CGRP receptor is a complex between calcitonin receptor-like receptor (CLR), a family B G-protein-coupled receptor (GPCR) and receptor activity-modifying protein 1 (RAMP1). A third protein, receptor component protein (RCP) is needed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7e3066544aa02672ad7ccaf37513edc
https://pubmed.ncbi.nlm.nih.gov/29797088
https://pubmed.ncbi.nlm.nih.gov/29797088
Publikováno v:
Calcitonin Gene-Related Peptide (CGRP) Mechanisms ISBN: 9783030214531
The canonical CGRP receptor is a complex between calcitonin receptor-like receptor (CLR), a family B G-protein-coupled receptor (GPCR) and receptor activity-modifying protein 1 (RAMP1). A third protein, receptor component protein (RCP) is needed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::374dd2b7d7ad25be30cb50e0bd62764c
https://doi.org/10.1007/164_2018_132
https://doi.org/10.1007/164_2018_132