Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Romesh R Subramanian"'
Autor:
Daniel R Caffrey, Juan Zhao, Zhili Song, Michael E Schaffer, Steven A Haney, Romesh R Subramanian, Albert B Seymour, Jason D Hughes
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21503 (2011)
Small interfering RNAs (siRNAs) are routinely used to reduce mRNA levels for a specific gene with the goal of studying its function. Several studies have demonstrated that siRNAs are not always specific and can have many off-target effects. The 3' UT
Externí odkaz:
https://doaj.org/article/80e4e30b2ce941189f40e0e34dd04ae8
Autor:
Frank S. French, James L. Mohler, Elizabeth M. Wilson, Haian Fu, Romesh R. Subramanian, O. Harris Ford, Christopher W. Gregory, Jiann-an Tan, Mark A. Titus
Purpose: Androgen receptor abundance and androgen receptor–regulated gene expression in castration-recurrent prostate cancer are indicative of androgen receptor activation in the absence of testicular androgen. Androgen receptor transactivation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731e8ae160bc2bf5bd0e7517093f65dc
https://doi.org/10.1158/1078-0432.c.6517594
https://doi.org/10.1158/1078-0432.c.6517594
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 6, Pp 1265-1271 (2011)
Apolipoprotein CIII (apoCIII), a major constituent of triglyceride-rich lipoprotein, has been proposed as a key contributor to hypertriglyceridemia on the basis of its inhibitory effects on lipoprotein lipase. Many immunochemical methods have been de
Externí odkaz:
https://doaj.org/article/aab0bf7dbe6d4441be42eb8ba450d9e8
Autor:
Romesh R. Subramanian, Jeffrey M Brown, Rebecca L Miller, Jeremiah D. Farelli, Kirtika H. Asrani, Mary R Stahley, Christopher J. Cheng
Publikováno v:
RNA Biology. :1-7
mRNA based therapies hold great promise for the treatment of genetic diseases. However, this therapeutic approach suffers from multiple challenges including the short half-life of exogenously administered mRNA and subsequent protein production. Modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95d75bc58c0e4526c554d18dc558f67
https://doi.org/10.1080/15476286.2018.1450054
https://doi.org/10.1080/15476286.2018.1450054
Autor:
Anjli Kukreja, Angel L. Pey, Susan Sobolov, Jian-Ping Tang, Xiang Gao, Melissa A. Lasaro, Eduardo Salido, Romesh R. Subramanian, Christian Cobaugh, Cristina Martin-Higueras, Chris Forbes
Publikováno v:
Nucleic acid therapeutics. 29(2)
Primary Hyperoxaluria Type 1 (PH1) is an autosomal recessive disorder of glyoxylate metabolism. Loss of alanine glyoxylate aminotransferase (AGT) function to convert intermediate metabolite glyoxylate to glycine causes the accumulation and reduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c334bb65fe3806467b5a3378eb18e6e9
https://pubmed.ncbi.nlm.nih.gov/30676254
https://pubmed.ncbi.nlm.nih.gov/30676254
Publikováno v:
RNA biology. 15(7)
Arginase I (ARG1) deficiency is an autosomal recessive urea cycle disorder, caused by deficiency of the enzyme Arginase I, resulting in accumulation of arginine in blood. Current Standard of Care (SOC) for ARG1 deficiency in patients or those having
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142a0433a5dbd653086b7da389bffd8e
https://pubmed.ncbi.nlm.nih.gov/29923457
https://pubmed.ncbi.nlm.nih.gov/29923457
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Thrombotic thrombocytopenic purpura (TTP) is primarily caused by deficiency of ADAMTS13 within the blood stream due to either genetic defects or presence of inhibitory autoantibodies. Preclinical and clinical studies suggest that enzyme replacement t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be39e2e78d43e5f861e52e839b2ea5a6
http://europepmc.org/articles/PMC5959889
http://europepmc.org/articles/PMC5959889
Autor:
Kirtika H. Asrani, Cleo Isaacs, Tayeba Khan, Lucy S. Jun, Romesh R. Subramanian, Jeremiah D. Farelli, Daniel S. Roseman, Fabienne Rajas
Publikováno v:
Molecular Therapy
Molecular Therapy, Cell Press, 2018, 26 (3), pp.814-821. ⟨10.1016/j.ymthe.2018.01.006⟩
Molecular Therapy, Cell Press, 2018, 26 (3), pp.814-821. ⟨10.1016/j.ymthe.2018.01.006⟩
Glycogen storage disease type Ia (GSD1a) is an inherited metabolic disorder caused by the deficiency of glucose-6-phosphatase (G6Pase). GSD1a is associated with life-threatening hypoglycemia and long-term liver and renal complications. We examined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f0933a87b2cba1fcb035e6b7f207bb
https://www.hal.inserm.fr/inserm-02379178/document
https://www.hal.inserm.fr/inserm-02379178/document
Autor:
Kirtika H. Asrani, Joanna S deBear, Melissa A. Lasaro, Romesh R. Subramanian, Anumeha Shah, Jeremiah D. Farelli, Cleo Isaacs, Christopher J. Cheng, Mary R Stahley
Publikováno v:
Nucleic acid therapeutics. 28(2)
Messenger RNA (mRNA) is a promising new class of therapeutics that has potential for treatment of diseases in fields such as immunology, oncology, vaccines, and inborn errors of metabolism. mRNA therapy has several advantages over DNA-based gene ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fe68fd83b1d5913b3d65fade6a4be7
https://pubmed.ncbi.nlm.nih.gov/29437538
https://pubmed.ncbi.nlm.nih.gov/29437538
Publikováno v:
Journal of Nucleic Acids, Vol 2018 (2018)
Journal of Nucleic Acids
Journal of Nucleic Acids
Alpha-1-antitrypsin (AAT) deficiency is a genetic disorder that produces inactive/defective AAT due to mutations in the SERPINA1 gene encoding AAT. This disease is associated with decreased activity of AAT in the lungs and deposition of excessive def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a4c02458f8ff407e8284b710ea0b9f
https://doaj.org/article/e2a344f5f9dc486393462777e4964734
https://doaj.org/article/e2a344f5f9dc486393462777e4964734