CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.

Autor: Waarts MR; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York., Mowla S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Boileau M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Martinez Benitez AR; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Sango J; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.; Center for Advancement of Blood Cancer Therapies, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Bagish M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Fernández-Maestre I; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York., Shan Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Eisman SE; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Park YC; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Wereski M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Csete I; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., O'Connor K; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Romero-Vega AC; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Miles LA; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio., Xiao W; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Wu X; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Koche RP; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Shih AH; Division of Hematology Oncology, Department of Medicine, Tisch Cancer Institute (TCI), Icahn School of Medicine at Mount Sinai, New York, New York., Papapetrou EP; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.; Center for Advancement of Blood Cancer Therapies, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Butler JM; Department of Medicine, University of Florida Health Cancer Center, Gainesville, Florida., Cai SF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Leukemia Service, Department of Medicine, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York., Bowman RL; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Publikováno v: Cancer discovery [Cancer Discov] 2024 Oct 04; Vol. 14 (10), pp. 1860-1878.