Bcl-2 supports survival and metabolic fitness of quiescent tissue-resident ILC3

Autor: King, James I., Melo-Gonzalez, Felipe, Malengier-Devlies, Bert, Tachó-Piñot, Roser, Magalhaes, Marlene S, Hodge, Suzanne H., Romero Ros, Xavier, Gentek, Rebecca, Hepworth, Matthew R.

Publikováno v: In Mucosal Immunology July 2023

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

Autor: Bernink, Jochem H., Ohne, Yoichiro, Teunissen, Marcel B. M., Wang, Jingya, Wu, Jincheng, Krabbendam, Lisette, Guntermann, Christine, Volckmann, Richard, Koster, Jan, van Tol, Sophie, Ramirez, Ivan, Shrestha, Yashaswi, de Rie, Menno A., Spits, Hergen, Romero Ros, Xavier, Humbles, Alison A.

Publikováno v: Nature Immunology; August 2019, Vol. 20 Issue: 8 p992-1003, 12p

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Autor: Lenos, Kristiaan, Miedema, Daniël, Lodestijn, Sophie, Nijman, Lisanne, Bosch, Tom, Romero Ros, Xavier, Lourenço, Filipe, Lecca, Maria, Heijden, Maartje, Neerven, Sanne, Oort, Anita, Leveille, Nicolas, Adam, Ronja, de Sousa E Melo, Felipe, Otten, Joy, Veerman, Patrick, Hypolite, Guillaume, Koens, Lianne, Lyons, Scott, Stassi, Giorgio, Winton, Douglas, Medema, Jan, Morrissey, Edward, Bijlsma, Maarten, Vermeulen, Louis

Publikováno v: Nature Cell Biology; October 2018, Vol. 20 Issue: 10 p1193-1202, 10p

Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.

Autor: Strickson S; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; These authors contributed equally to this work., Houslay KF; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; These authors contributed equally to this work., Negri VA; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Ohne Y; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Ottosson T; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Dodd RB; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Huntington CC; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Baker T; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Li J; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Stephenson KE; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., O'Connor AJ; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Sagawe JS; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Killick H; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Moore T; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rees DG; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Koch S; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Sanden C; Experimental Medical Sciences, Lund University, Lund, Sweden.; Medetect AB, Lund, Sweden., Wang Y; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Gubbins E; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Ghaedi M; Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Kolbeck R; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.; Current: Spirovant Sciences, Philadelphia, PA, USA., Saumyaa S; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Erjefält JS; Experimental Medical Sciences, Lund University, Lund, Sweden.; Allergology and Respiratory Medicine, Lund University, Skåne University Hospital, Lund, Sweden., Sims GP; Bioscience Immunology, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Humbles AA; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Current: Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland., Scott IC; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Romero Ros X; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; These authors contributed equally to this work., Cohen ES; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK suzanne.cohen@astrazeneca.com.; These authors contributed equally to this work.

Publikováno v: The European respiratory journal [Eur Respir J] 2023 Sep 28; Vol. 62 (3). Date of Electronic Publication: 2023 Sep 28 (Print Publication: 2023).