Inhibition of YTHDF1 by salvianolic acid overcomes gluten-induced intestinal inflammation.

Autor: Olazagoitia-Garmendia A; Department of Biochemistry and Molecular Biology, University of the Basque Country, UPV/EHU, Leioa, Spain.; Biobizkaia Health Research Institute, Barakaldo, Spain., Rojas-Márquez H; Biobizkaia Health Research Institute, Barakaldo, Spain.; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, Spain., Romero MDM; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Ruiz P; Research Centre for Experimental Marine Biology and Biotechnology (PiE-UPV/EHU), University of the Basque Country, UPV/EHU, Plentzia, Spain.; BCTA Research Group, Department of Zoology and Animal Cell Biology, University of the Basque Country, UPV-EHU, Leioa, Spain., Agirre-Lizaso A; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, Donostia-san Sebastian, Spain., Chen Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Beijing, Beijing, China., Perugorria MJ; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, Donostia-san Sebastian, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, Leioa, Spain.; Centro de Investigación Biomédica en Red enfermedades hepaticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., Herrero L; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Serra D; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Luo C; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Beijing, Beijing, China.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China., Bujanda L; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, Donostia-san Sebastian, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, Leioa, Spain.; Centro de Investigación Biomédica en Red enfermedades hepaticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., He C; Department of Chemistry, Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.; Howard Hughes Medical Institute, Chicago, Illinois, USA., Castellanos-Rubio A; Biobizkaia Health Research Institute, Barakaldo, Spain ainara.castellanos@ehu.eus.; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.

Publikováno v: Gut [Gut] 2024 Aug 08; Vol. 73 (9), pp. 1590-1592. Date of Electronic Publication: 2024 Aug 08.

Sex-Dependent Metabolic Effects in Diet-Induced Obese Rats following Intermittent Fasting Compared with Continuous Food Restriction.

Autor: Bosch de Basea L; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain., Boguñà M; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain., Sánchez A; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain., Esteve M; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.; CIBER Obesity and Nutrition, Institute of Health Carlos III, 08028 Madrid, Spain.; Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain., Grasa M; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.; CIBER Obesity and Nutrition, Institute of Health Carlos III, 08028 Madrid, Spain.; Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain., Romero MDM; CIBER Obesity and Nutrition, Institute of Health Carlos III, 08028 Madrid, Spain.; Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain.; Department of Biochemistry and Physiology, Faculty of Pharmacy, University of Barcelona, 02028 Barcelona, Spain.

Publikováno v: Nutrients [Nutrients] 2024 Mar 29; Vol. 16 (7). Date of Electronic Publication: 2024 Mar 29.

Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation.

Autor: Helsley RN; Department of Pediatrics and Gastroenterology, University of Kentucky, Lexington, KY, USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA; Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Park SH; Department of Pediatrics and Gastroenterology, University of Kentucky, Lexington, KY, USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA., Vekaria HJ; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, USA., Sullivan PG; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, USA., Conroy LR; Department of Neuroscience, University of Kentucky, Lexington, KY, USA., Sun RC; Department of Neuroscience, University of Kentucky, Lexington, KY, USA; Department of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL, USA; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, USA., Romero MDM; School of Pharmacy, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, 08028, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain., Herrero L; School of Pharmacy, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, 08028, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain., Bons J; Chemistry & Mass Spectrometry, Buck Institute for Research on Aging, Novato, CA, USA., King CD; Chemistry & Mass Spectrometry, Buck Institute for Research on Aging, Novato, CA, USA., Rose J; Chemistry & Mass Spectrometry, Buck Institute for Research on Aging, Novato, CA, USA., Meyer JG; Chemistry & Mass Spectrometry, Buck Institute for Research on Aging, Novato, CA, USA; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Schilling B; Chemistry & Mass Spectrometry, Buck Institute for Research on Aging, Novato, CA, USA., Kahn CR; Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA, USA., Softic S; Department of Pediatrics and Gastroenterology, University of Kentucky, Lexington, KY, USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA; Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: samir.softic@uky.edu.

Publikováno v: Journal of hepatology [J Hepatol] 2023 Jul; Vol. 79 (1), pp. 25-42. Date of Electronic Publication: 2023 Feb 21.

CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst.

Autor: Zagmutt S; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Mera P; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., González-García I; NeurObesity Group, Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Ibeas K; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Romero MDM; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Obri A; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Martin B; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, 08028, Barcelona, Spain., Esteve-Codina A; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, 08028, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Soler-Vázquez MC; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Bastias-Pérez M; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Cañes L; Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC), Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.; Instituto de Investigación Biomédica Sant Pau (IIB-Sant Pau), Barcelona, Spain., Augé E; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Pelegri C; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Institute of Neurosciences of the Universitat de Barcelona, Barcelona, Spain., Vilaplana J; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Institute of Neurosciences of the Universitat de Barcelona, Barcelona, Spain., Ariza X; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.; Department of Inorganic & Organic Chemistry, Faculty of Chemistry, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., García J; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.; Department of Inorganic & Organic Chemistry, Faculty of Chemistry, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain., Martinez-González J; Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC), Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.; Instituto de Investigación Biomédica Sant Pau (IIB-Sant Pau), Barcelona, Spain., Casals N; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.; Department of Basic Sciences, Faculty of Medicine & Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain., López M; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.; NeurObesity Group, Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Palmiter R; Department of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Sanz E; Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain., Quintana A; Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain., Herrero L; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain., Serra D; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain. dserra@ub.edu.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain. dserra@ub.edu.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. dserra@ub.edu.

Publikováno v: Biology of sex differences [Biol Sex Differ] 2023 Mar 25; Vol. 14 (1), pp. 14. Date of Electronic Publication: 2023 Mar 25.

A bacteraemia risk prediction model: development and validation in an emergency medicine population.

Autor: Julián-Jiménez A; Emergency Department, Complejo Hospitalario Universitario de Toledo, Universidad de Castilla La Mancha, Toledo, Spain., González Del Castillo J; Emergency Department, Hospital Universitario Clínico San Carlos, Calle Profesor Martín Lagos Calle Profesor Martín Lagos, 28040, Madrid, Spain. jgonzalezcast@gmail.com.; Health Research Institute (IdISSC), Hospital Universitario San Carlos, Madrid, Spain. jgonzalezcast@gmail.com., García-Lamberechts EJ; Emergency Department, Hospital Universitario Clínico San Carlos, Calle Profesor Martín Lagos Calle Profesor Martín Lagos, 28040, Madrid, Spain.; Health Research Institute (IdISSC), Hospital Universitario San Carlos, Madrid, Spain., Huarte Sanz I; Emergency Department, Hospital Universitario de Donostia, San Sebastian, Spain., Navarro Bustos C; Emergency Department, Hospital Universitario Virgen de La Macarena, Sevilla, Spain., Rubio Díaz R; Emergency Department, Complejo Hospitalario Universitario de Toledo, Universidad de Castilla La Mancha, Toledo, Spain., Guardiola Tey JM; Emergency Department, Hospital Universitario Sant Pau, Barcelona, Spain., Llopis-Roca F; Emergency Department, Hospital Universitario de Bellvitge, Barcelona, Spain., Piñera Salmerón P; Emergency Department, Hospital Universitario Reina Sofía, Murcia, Spain., de Martín-Ortiz de Zarate M; Emergency Department, Hospital Universitario de Basurto, Bilbao, Spain., Álvarez-Manzanares J; Emergency Department, Hospital Universitario Rio Hortega, Valladolid, Spain., Gamazo-Del Rio JJ; Emergency Department, Hospital Universitario de Galdakao-Usansolo, Bizkaia, Spain., Álvarez Alonso M; Emergency Department, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain., Mora Ordoñez B; Emergency Department, Hospital Virgen de La Victoria, Málaga, Spain., Álvarez López O; Emergency Department, Hospital Universitario de Móstoles, Madrid, Spain., Ortega Romero MDM; Emergency Department, Hospital Clínic, Barcelona, Spain., Sousa Reviriego MDM; Emergency Department, Hospital Nuestra Señora del Prado, Talavera de La Reina, Spain., Perales Pardo R; Emergency Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain., Villena García Del Real H; Emergency Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela , Spain., Marchena González MJ; Emergency Department, Hospital Juan Ramón Jiménez de Huelva, Huelva, Spain., Ferreras Amez JM; Emergency Department, Hospital Clínico Universitario Lozano Blesa de Zaragoza, Zaragoza, Spain., González Martínez F; Emergency Department, Hospital Virgen de La Luz de Cuenca, Cuenca, Spain., Martín-Sánchez FJ; Emergency Department, Hospital Universitario Clínico San Carlos, Calle Profesor Martín Lagos Calle Profesor Martín Lagos, 28040, Madrid, Spain.; Health Research Institute (IdISSC), Hospital Universitario San Carlos, Madrid, Spain., Beneyto Martín P; Research Unit, Complejo Hospitalario Universitario de Toledo, Toledo, Spain., Candel González FJ; Clinical Microbiology Department, Hospital Universitario Clínico San Carlos, Madrid, Spain., Díaz-Honrubia AJ; Biomedical Technology Center - E.T.S. of Computer Engineers, Universidad Politécnica de Madrid, Madrid, Spain.

Publikováno v: Infection [Infection] 2022 Feb; Vol. 50 (1), pp. 203-221. Date of Electronic Publication: 2021 Sep 06.