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Uptake and cytotoxicity of citrate-coated gold nanospheres: Comparative studies on human endothelial and epithelial cells

Autor: Freese Christian, Uboldi Chiara, Gibson Matthew I, Unger Ronald E, Weksler Babette B, Romero Ignacio A, Couraud Pierre-Olivier, Kirkpatrick C

Publikováno v: Particle and Fibre Toxicology, Vol 9, Iss 1, p 23 (2012)

Abstract Background The use of gold nanoparticles (AuNPs) for diagnostic applications and for drug and gene-delivery is currently under intensive investigation. For such applications, biocompatibility and the absence of cytotoxicity of AuNPs is essen

Externí odkaz: https://doaj.org/article/2610dc143ffe49799320ed0cb7362eab

Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro

Autor: Chaitanya Ganta V, Cromer Walter E, Wells Shannon R, Jennings Merilyn H, Couraud P Olivier, Romero Ignacio A, Weksler Babette, Erdreich-Epstein Anat, Mathis J Michael, Minagar Alireza, Alexander J Steven

Publikováno v: Journal of Neuroinflammation, Vol 8, Iss 1, p 162 (2011)

Abstract The glio-vascular unit (G-unit) plays a prominent role in maintaining homeostasis of the blood-brain barrier (BBB) and disturbances in cells forming this unit may seriously dysregulate BBB. The direct and indirect effects of cytokines on cel

Externí odkaz: https://doaj.org/article/cadb4363a0b5479cb61508bd5a9c8814

Role of KCNMA1 gene in breast cancer invasion and metastasis to brain

Autor: Couraud Pierre-Olivier, Romero Ignacio A, Meister Edward A, Weksler Babette, Sankpal Umesh T, Khaitan Divya, Ningaraj Nagendra S

Publikováno v: BMC Cancer, Vol 9, Iss 1, p 258 (2009)

Abstract Background The prognosis for patients with breast tumor metastases to brain is extremely poor. Identification of prognostic molecular markers of the metastatic process is critical for designing therapeutic modalities for reducing the occurre

Externí odkaz: https://doaj.org/article/0491cdbd115d4b2c9f76531cfd34e913

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal.

Autor: Lau KX; Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, 3010, Australia., Mason EA; Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, 3010, Australia.; Centre for Stem Cell Systems, Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, 3010, Australia., Kie J; Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, 3010, Australia., De Souza DP; Metabolomics Australia, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, 3052, Australia., Kloehn J; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, 3052, Australia., Tull D; Metabolomics Australia, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, 3052, Australia., McConville MJ; Metabolomics Australia, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, 3052, Australia.; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, 3052, Australia., Keniry A; Division of Molecular Medicine, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, 3010, Australia., Beck T; Division of Molecular Medicine, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia., Blewitt ME; Division of Molecular Medicine, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, 3010, Australia., Ritchie ME; Division of Molecular Medicine, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia., Naik SH; Division of Molecular Medicine, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia., Zalcenstein D; Division of Molecular Medicine, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia., Korn O; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, 4072, Australia., Su S; Division of Molecular Medicine, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia., Romero IG; Melbourne Integrative Genomics, School of Biosciences, University of Melbourne, Melbourne, Victoria, 3010, Australia., Spruce C; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Baker CL; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., McGarr TC; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Wells CA; Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, 3010, Australia.; Centre for Stem Cell Systems, Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, 3010, Australia.; Divisions of Cancer and Hematology and Molecular Medicine, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia., Pera MF; Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, 3010, Australia. martin.pera@jax.org.; Division of Molecular Medicine, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria, 3052, Australia. martin.pera@jax.org.; The Jackson Laboratory, Bar Harbor, ME, 04609, USA. martin.pera@jax.org.; The Florey Institute of Neuroscience and Mental Health, 30 Royal Parade, Parkville, Victoria, 3052, Australia. martin.pera@jax.org.

Publikováno v: Nature communications [Nat Commun] 2020 May 15; Vol. 11 (1), pp. 2420. Date of Electronic Publication: 2020 May 15.