Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension.

Autor: Collaco JM; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA., Abman SH; Department of Pediatrics Children's Hospital Colorado Aurora Colorado USA., Austin ED; Department of Pediatrics Vanderbilt University Medical Center Nashville Tennessee USA., Avitabile CM; Department of Pediatrics, Children's Hospital of Philadelphia University of Pennsylvania Philadelphia Pennsylvania USA., Bates A; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA., Fineman JR; Department of Pediatrics University of California San Francisco California USA., Freire GA; Department of Pediatrics Johns Hopkins All Children's Hospital St. Petersburg Florida USA., Handler SS; Department of Pediatrics Medical College of Wisconsin Milwaukee Wisconsin USA., Ivy DD; Department of Pediatrics Children's Hospital Colorado Aurora Colorado USA., Krishnan US; Department of Pediatrics, Vagelos College of Physicians and Surgeons Columbia University New York New York USA., Mullen MP; Department of Pediatrics Boston Children's Hospital Boston Massachusetts USA., Varghese NP; Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas USA., Yung D; Department of Pediatrics University of Washington School of Medicine Seattle Washington USA., Nies MK; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA., Everett AD; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA., Zimmerman KO; Departments of Biostatistics and Bioinformatics, Department of Pediatrics, Duke Clinical Research Institute Duke University Durham North Carolina USA., Simmons W; Departments of Biostatistics and Bioinformatics, Department of Pediatrics, Duke Clinical Research Institute Duke University Durham North Carolina USA., Chakraborty H; Departments of Biostatistics and Bioinformatics, Department of Pediatrics, Duke Clinical Research Institute Duke University Durham North Carolina USA., Yenokyan G; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA., Newell-Sturdivant A; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA.; Department of Neurology, Johns Hopkins School of Medicine BIOS Clinical Trials Coordinating Center (CTCC) Baltimore Maryland USA., Christensen E; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA.; Department of Neurology, Johns Hopkins School of Medicine BIOS Clinical Trials Coordinating Center (CTCC) Baltimore Maryland USA., Eyzaguirre LM; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA.; Department of Neurology, Johns Hopkins School of Medicine BIOS Clinical Trials Coordinating Center (CTCC) Baltimore Maryland USA., Hanley DF; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA.; Department of Neurology, Johns Hopkins School of Medicine BIOS Clinical Trials Coordinating Center (CTCC) Baltimore Maryland USA., Rosenzweig EB; Department of Pediatrics, Vagelos College of Physicians and Surgeons Columbia University New York New York USA., Romer LH; Departments of Pediatrics, Neurology, Anesthesiology and Critical Care Medicine, and Biostatistics Johns Hopkins University School of Medicine Baltimore Maryland USA.

Publikováno v: Pulmonary circulation [Pulm Circ] 2023 Oct 31; Vol. 13 (4), pp. e12305. Date of Electronic Publication: 2023 Oct 31 (Print Publication: 2023).

Biallelic variants of ATP13A3 cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality.

Autor: Machado RD; Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK., Welch CL; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA., Haimel M; NIHR Bioresource - Rare Diseases, University of Cambridge, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, Cambridgeshire, UK., Bleda M; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, Cambridgeshire, UK., Colglazier E; Department of Nursing, University of California San Francisco, San Francisco, California, USA., Coulson JD; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Debeljak M; Clinical Institute of Special Laboratory Diagnostics, University Medical Centre Ljubljana, University Children's Hospital, Ljubljana, Slovenia.; Faculty of Medicine, Institute of Cell Biology, University of Ljubljana, Ljubljana, Slovenia., Ekstein J; Dor Yeshorim, Committee for Prevention of Jewish Genetic Diseases, Brooklyn, New York, USA., Fineman JR; Department of Pediatrics and Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA., Golden WC; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Griffin EL; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA., Hadinnapola C; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, Cambridgeshire, UK., Harris MA; Vici Syndrome Foundation, Inc, Silver Spring, Maryland, USA., Hirsch Y; Dor Yeshorim, Committee for Prevention of Jewish Genetic Diseases, Brooklyn, New York, USA., Hoover-Fong JE; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Nogee L; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Romer LH; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Anesthesiology and Critical Care Medicine, Cell Biology, Biomedical Engineering, and the Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Vesel S; Department of Cardiology, University Medical Centre Ljubljana, University Children's Hospital, Ljubljana, Slovenia.; Department of Paediatrics, Teaching Hospital Celje, Celje, Slovenia., Gräf S; NIHR Bioresource - Rare Diseases, University of Cambridge, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, Cambridgeshire, UK., Morrell NW; NIHR Bioresource - Rare Diseases, University of Cambridge, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, Cambridgeshire, UK., Southgate L; Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK., Chung WK; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA wkc15@columbia.edu.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Publikováno v: Journal of medical genetics [J Med Genet] 2022 Sep; Vol. 59 (9), pp. 906-911. Date of Electronic Publication: 2021 Sep 07.

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3D printing and characterization of a soft and biostable elastomer with high flexibility and strength for biomedical applications.

Autor: Bachtiar EO; Department of Mechanical Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA; Hopkins Extreme Materials Institute, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA., Erol O; Department of Mechanical Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA; Hopkins Extreme Materials Institute, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA., Millrod M; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe St, Baltimore, MD 21205, USA., Tao R; Hopkins Extreme Materials Institute, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA., Gracias DH; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA; Department of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA., Romer LH; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe St, Baltimore, MD 21205, USA; Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA; Departments of Cell Biology, Pediatrics, and the Center for Cell Dynamics, Johns Hopkins University, 725 North Wolfe St, Baltimore, MD 21205, USA., Kang SH; Department of Mechanical Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA; Hopkins Extreme Materials Institute, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA; Institute for NanoBioTechnology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA. Electronic address: shkang@jhu.edu.

Publikováno v: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2020 Apr; Vol. 104, pp. 103649. Date of Electronic Publication: 2020 Jan 23.

Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.

Autor: Weiss SL; Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. WeissS@email.chop.edu., Peters MJ; Great Ormond Street Hospital for Children, London, UK., Alhazzani W; Department of Medicine, Division of Critical Care, and Department of Health Research Methods and Impact, McMaster University, Hamilton, ON, Canada., Agus MSD; Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Anesthesiology, Critical Care and Pain, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Flori HR; C.S. Mott Children's Hospital, Ann Arbor, MI, USA., Inwald DP; St. Mary's Hospital, London, UK., Nadel S; St. Mary's Hospital, London, UK., Schlapbach LJ; Paediatric Critical Care Research Group, The University of Queensland and Queensland Children's Hospital, Brisbane, QLD, Australia., Tasker RC; Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Argent AC; Red Cross War Memorial Children's Hospital and University of Cape Town, Cape Town, South Africa., Brierley J; Great Ormond Street Hospital for Children, London, UK., Carcillo J; Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Carrol ED; University of Liverpool, Liverpool, UK., Carroll CL; Connecticut Children's Medical Center, Hartford, CT, USA., Cheifetz IM; Duke Children's Hospital, Durham, NC, USA., Choong K; Department of Medicine, Division of Critical Care, and Department of Health Research Methods and Impact, McMaster University, Hamilton, ON, Canada., Cies JJ; St. Christopher's Hospital for Children, Philadelphia, PA, USA., Cruz AT; Texas Children's Hospital, Houston, TX, USA., De Luca D; Paris South University Hospitals, Assistance Publique Hopitaux de Paris, Paris, France.; Physiopathology and Therapeutic Innovation Unit-INSERM U999, South Paris-Saclay University, Paris, France., Deep A; King's College Hospital, London, UK., Faust SN; University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK., De Oliveira CF; The Latin America Sepsis Institute, São Paulo, Brazil., Hall MW; Nationwide Children's Hospital, Columbus, OH, USA., Ishimine P; Rady Children's Hospital, San Diego, CA, USA., Javouhey E; Centre Hospitalier Universitaire de Lyon, Lyon, France., Joosten KFM; Erasmus University Medical Center, Rotterdam, The Netherlands., Joshi P; All India Institute of Medical Sciences, New Delhi, India., Karam O; Children's Hospital of Richmond at VCU, Richmond, VA, USA., Kneyber MCJ; Beatrix Children's Hospital, Groningen, The Netherlands., Lemson J; Radboud University Medical Centre, Nijmegen, The Netherlands., MacLaren G; National University Health System, Singapore, Singapore.; Royal Children's Hospital, Melbourne, VIC, Australia., Mehta NM; Department of Anesthesiology, Critical Care and Pain, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Møller MH; Rigshospitalet Hospital, Copenhagen, Denmark., Newth CJL; Children's Hospital of Los Angeles, Los Angeles, CA, USA., Nguyen TC; Texas Children's Hospital, Houston, TX, USA., Nishisaki A; Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Nunnally ME; New York University Langone Medical Center, New York, NY, USA., Parker MM; Stony Brook University, Stony Brook, NY, USA., Paul RM; Advocate Children's Hospital, Park Ridge, IL, USA., Randolph AG; Department of Anesthesiology, Critical Care and Pain, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Ranjit S; Apollo Hospitals, Chennai, India., Romer LH; Johns Hopkins Children's Center, Baltimore, MD, USA., Scott HF; Children's Hospital Colorado, Aurora, CO, USA., Tume LN; University of the West of England, Bristol, UK., Verger JT; Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; College of Nursing, University of Iowa, Iowa City, IA, USA., Williams EA; Texas Children's Hospital, Houston, TX, USA., Wolf J; St. Jude Children's Research Hospital, Memphis, TN, USA., Wong HR; Cincinnati Children's Hospital, Cincinnati, OH, USA., Zimmerman JJ; Seattle Children's Hospital, Seattle, WA, USA., Kissoon N; British Columbia Children's Hospital, Vancouver, BC, Canada., Tissieres P; Paris South University Hospitals, Assistance Publique Hopitaux de Paris, Paris, France.; Institute of Integrative Biology of the Cell-CNRS, CEA, Univ Paris Sud, Gif-sur-Yvette, France.

Publikováno v: Intensive care medicine [Intensive Care Med] 2020 Feb; Vol. 46 (Suppl 1), pp. 1-9.