Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Romeo Ciabatti"'
Synthesis and Preliminary Biological Characterization of New Semisynthetic Derivatives of Ramoplanin
Autor:
Anna Checchia, Matteo Giannone, Gianbattista Panzone, Augusto Canavesi, Romeo Ciabatti, Franca Castiglione, Gianpaolo Candiani, Sonia I. Maffioli, Elena Michelucci, Paolo Simone Tiseni, Cristina Brunati, Ettore Marzorati, Daniela Jabes, Gabriella Romano
Publikováno v:
Journal of Medicinal Chemistry. 50:3077-3085
Ramoplanin is a glycolipodepsipeptide antibiotic active against Gram-positive bacteria including vancomycin-resistant enterococci. Ramoplanin inhibits bacterial cell wall biosynthesis by a mechanism different from that of glycopeptides and hence does
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0710b9be92762b5747f2794737d740
https://doi.org/10.1021/jm070042z
https://doi.org/10.1021/jm070042z
Autor:
Shaoqing Chen, Stuart Lam, Romeo Ciabatti, Joaquim Trias, Richard White, Gianpaolo Candiani, C J Hackbarth, Jeffrey W. Jacobs, Stefano Donadio, Eric M. Gordon, Jeffrey Clough, Gabriella Romano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3409-3414
Thiazole peptide GE2270 A (1) possesses potent antimicrobial activity against many gram-positive pathogens, including methicillin resistant Staphylococcus aureus (S. aureus, MRSA; MIC(90)=0.06 microg/mL) and vancomycin resistant Enterococcus spp. (VR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d111a58079a2ce745ca40d1ecac6d631
https://doi.org/10.1016/s0960-894x(03)00811-4
https://doi.org/10.1016/s0960-894x(03)00811-4
Autor:
Riccardo Bonfichi, Romeo Ciabatti, Paolo Tavecchia, Sergio Lociuro, Luigi Colombo, Michael Kurz, Ettore Marzorati, Enrico Selva
Publikováno v:
Tetrahedron. 52:8763-8774
Controlled acid hydrolysis of compound 2 resulted in the selective opening of the macrocycle while in basic condition a retro-aldol reaction occurred at the level of phenylserine thiazole. Compound 2 can be easily prepared from the natural antibiotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dbb66d887fc25a9c185170369493a27
https://doi.org/10.1016/0040-4020(96)00417-6
https://doi.org/10.1016/0040-4020(96)00417-6
Autor:
Pietro Ferrari, Károly Vékey, Romeo Ciabatti, Adriano Malabarba, Maurizio Denaro, and Elvio Bellasio, Jürgen Kettenring
Publikováno v:
The Journal of Organic Chemistry. 61:2137-2150
Reaction of teicoplanin glycopeptides with sodium borohydride in aqueous ethanol solutions produced open pentapeptide derivatives in which the amide bond between amino acids 2 and 3 was hydrolyzed and the carboxyl group of amino acid 2 was reduced to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d73786fb66ff6a80b1d1eb9b7e2d6386
https://doi.org/10.1021/jo941809v
https://doi.org/10.1021/jo941809v
Autor:
Ermenegildo Restelli, Marisa Berti, Beth P. Goldsteinn, Romeo Ciabatti, Gabriella Romano, F Ripamonti, Rolf Heinz Hermann, Pietro Ferrari
Publikováno v:
The Journal of Antibiotics. 49:1236-1248
Starting from the antibiotic A-40926 and the aglycone of A-40926 a series of compounds were prepared by modifying the free functionalities. Their antimicrobial activity was determined, particularly against Neisseria gonorrhoeae, against which A-40926
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895f3ebb829fb6ed5dbaaa633412c0c3
https://doi.org/10.7164/antibiotics.49.1236
https://doi.org/10.7164/antibiotics.49.1236
Autor:
Sergio Lociuro, Romeo Ciabatti, Riccardo Bonfichi, Paolo Tavecchia, Enrico Selva, Ermenegildo Restelli, Michael Kurz, Cristina Sottani, Patrizia Gentili
Publikováno v:
Tetrahedron. 51:4867-4890
Fragments of the thiopeptide antibiotic MDL 62,879 (GE2270A) were prepared under mild degradation conditions. Their structures were determined by spectroscopic techniques and by comparison to synthetic reference thiazolyl dipeptides. The two thiazoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f8a44f5187c97b13ab73a80cf5fd8d3
https://doi.org/10.1016/0040-4020(95)00171-4
https://doi.org/10.1016/0040-4020(95)00171-4
Autor:
Bianca Patrizia Andreini, Adriano Malabarba, Pietro Ferrari, Michael Kurz, Roberto Scotti, Beth P. Goldstein, Romeo Ciabatti, Maurizio Denaro
Publikováno v:
The Journal of Antibiotics. 48:869-883
A series of amide derivatives of natural glycopeptide A-40,926 (A), its 6B-methyl ester (MA) and 6B-decarboxy-6B-hydroxymethyl derivative (RA) were prepared with the aim of obtaining activity against glycopeptide-resistant enterococci. These compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711c2e0a4c780d67799c47b6b6884ae3
https://doi.org/10.7164/antibiotics.48.869
https://doi.org/10.7164/antibiotics.48.869
Autor:
Antonio Carrieri, Cosimo Altomare, Adriano Malabarba, Romeo Ciabatti, Saverio Cellamare, Angelo Carotti
Publikováno v:
Scopus-Elsevier
Structure-lipophilicity relationships of a large series of 63-COX teicoplanin antibiotic derivatives were examined, by correlating their capacity factors (log kw), measured through reversed-phase high-performance liquid chromatography on Deltabond C8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde7dfd45bd141c110ffbb4be367934c
https://doi.org/10.1111/j.2042-7158.1994.tb03255.x
https://doi.org/10.1111/j.2042-7158.1994.tb03255.x
Autor:
Maurizio Denaro, Pietro Ferrari, Jürgen Kettenring, Romeo Ciabatti, Roberto Scotti, Beth P. Goldstein, Adriano Malabarba
Publikováno v:
The Journal of Antibiotics. 47:1493-1506
Removal, by selective reduction, of the acetylglucosamine from teicoplanin A2-2 (CTA/2) produced the 34-de(acetylglucosaminyl)-34-deoxy pseudoaglycone (II). This compound was more active in vitro than CTA/2 against coagulase-negative staphylococci (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c17e420bbf5a1094f7c69d48393c6c
https://doi.org/10.7164/antibiotics.47.1493
https://doi.org/10.7164/antibiotics.47.1493
Publikováno v:
ChemInform. 26
A series of 5-membered heterocycles, structurally related to the known antibacterial oxazolidin-2-ones 1, have been prepared by modifying the model compound 1a at the 1-, 2-, 2′- and 3-positions. The antibacterial activity of compound 1a was strong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2df2df92e205ba7bdd7569bd038cc160
https://doi.org/10.1002/chin.199504176
https://doi.org/10.1002/chin.199504176