Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Romelyn DeLos Santos"'
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Akademický článek
Protocol for producing hyperpolarized 13C-bicarbonate for clinical MRI of extracellular pH in aggressive tumors
Autor: Changhua Mu, Xiaoxi Liu, Andrew Riselli, James Slater, Evelyn Escobar, Duy Dang, Scott Drapeau, Romelyn Delos Santos, Stacy Andosca, Hao Nguyen, Peder E.Z. Larson, Robert Bok, Daniel B. Vigneron, John Kurhanewicz, David M. Wilson, Robert R. Flavell
Publikováno v: STAR Protocols, Vol 5, Iss 3, Pp 103091- (2024)
Summary: Tumor acidosis is one of the hallmarks indicating the initiation and progression of various cancers. Here, we present a protocol for preparing a hyperpolarized (HP) 13C-bicarbonate tissue pH MRI imaging contrast agent to detect aggressive tu
Externí odkaz: https://doaj.org/article/26eee672a7554c34a6b37c0d4f69c4ee
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2
Akademický článek
Dual hyperpolarized [1-13C]pyruvate and [13C]urea magnetic resonance imaging of prostate cancer
Autor: Ivan de Kouchkovsky, Hao Nguyen, Hsin-Yu Chen, Xiaoxi Liu, Hecong Qin, Bradley A. Stohr, Romelyn Delos Santos, Michael A. Ohliger, Zhen Jane Wang, Robert A. Bok, Jeremy W. Gordon, Peder E.Z. Larson, Mary Frost, Kimberly Okamoto, Daniel Gebrezgiabhier, Matthew Cooperberg, Daniel B. Vigneron, John Kurhanewicz, Rahul Aggarwal
Publikováno v: Journal of Magnetic Resonance Open, Vol 21, Iss , Pp 100165- (2024)
Background: Although multiparametric (mp) 1H magnetic resonance imaging (MRI) is increasingly used to detect and localize prostate cancer (PC), its correlation with tumor grade is limited. Hyperpolarized (HP) carbon-13 (13C) MR is an emerging imaging
Externí odkaz: https://doaj.org/article/da8c42800e3a40d08d33e33696c21230
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3
Akademický článek
Defining the Magnetic Resonance Features of Renal Lesions and Their Response to Everolimus in a Transgenic Mouse Model of Tuberous Sclerosis Complex
Autor: Shubhangi Agarwal, Emilie Decavel-Bueff, Yung-Hua Wang, Hecong Qin, Romelyn Delos Santos, Michael J. Evans, Renuka Sriram
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Tuberous sclerosis complex (TSC) is an inherited genetic disorder characterized by mutations in TSC1 or TSC2 class of tumor suppressers which impact several organs including the kidney. The renal manifestations are usually in the form of angiomyolipo
Externí odkaz: https://doaj.org/article/b75e4148fb194f999cc6131b6ec6cafc
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4
Akademický článek
Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models
Autor: Jinny Sun, Robert A. Bok, Justin DeLos Santos, Deepti Upadhyay, Romelyn DeLos Santos, Shubhangi Agarwal, Mark Van Criekinge, Daniel B. Vigneron, Rahul Aggarwal, Donna M. Peehl, John Kurhanewicz, Renuka Sriram
Publikováno v: Metabolites, Vol 11, Iss 3, p 139 (2021)
Currently, no clinical methods reliably predict the development of castration-resistant prostate cancer (CRPC) that occurs almost universally in men undergoing androgen deprivation therapy. Hyperpolarized (HP) 13C magnetic resonance imaging (MRI) cou
Externí odkaz: https://doaj.org/article/ab5c99ec07eb48c4be910ef757df0008
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7
Data from Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment
Autor: Sabrina M. Ronen, Russell O. Pieper, Joseph F. Costello, Pavithra Viswanath, Romelyn Delos Santos, Anne Marie Gillespie, Donghyun Hong, Abigail R. Molloy, Georgios Batsios, Chloe Najac, Marina Radoul, Elavarasan Subramani
Although lower grade gliomas are driven by mutations in the isocitrate dehydrogenase 1 (IDH1) gene and are less aggressive than primary glioblastoma, they nonetheless generally recur. IDH1-mutant patients are increasingly being treated with temozolom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1282ce06292f8d9ca5ffe9177c6cd1aa
https://doi.org/10.1158/0008-5472.c.6512230
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9
Clinical translation of hyperpolarized 13C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging
Autor: Shuyu Tang, Gregory Goddard, James B. Slater, Rui Chen, Albert P. Chen, Rahul Aggarwal, Daniel B. Vigneron, Peder E. Z. Larson, Galen D. Reed, Renuka Sriram, Jeremy W. Gordon, Chunxin Tracy Zhang, Robert Bok, John Kurhanewicz, Mark Van Criekinge, Hecong Qin, Romelyn Delos Santos, Daniel M. Ruscitto, Andrew M. Riselli
Publikováno v: Magnetic resonance in medicine
PURPOSE The combined hyperpolarized (HP) 13 C pyruvate and urea MRI has provided a simultaneous assessment of glycolytic metabolism and tissue perfusion for improved cancer diagnosis and therapeutic evaluation in preclinical studies. This work aims t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e911eee2e7a4574ae565fc670ae3a869
http://europepmc.org/articles/PMC8616838
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10
Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized 13C MRI Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in a Prostate Cancer Mouse Model
Autor: Daniel B. Vigneron, BS Justin Delos Santos, Subramaniam Sukumar, John Kurhanewicz, Vickie Zhang, J. Adam M. Cunha, Jessie E. Lee, Peder E. Z. Larson, David M. Wilson, Renuka Sriram, Robert Bok, I-Chow Hsu, Hecong Qin, Romelyn Delos Santos
Publikováno v: International journal of radiation oncology, biology, physics, vol 107, iss 5
Purpose To investigate use of a novel imaging approach, hyperpolarized (HP) 13C magnetic resonance imaging (MRI) for simultaneous metabolism and perfusion assessment, to evaluate early and dose-dependent response to radiation therapy (RT) in a prosta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8124dc318c763e67e90a3a490bf1a8
https://doi.org/10.1016/j.ijrobp.2020.04.022
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