Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Romela Irene Ramos"'
Autor:
Sivan Izraely, Shlomit Ben‐Menachem, Orit Sagi‐Assif, Tsipi Meshel, Sapir Malka, Alona Telerman, Matias A. Bustos, Romela Irene Ramos, Metsada Pasmanik‐Chor, Dave S. B. Hoon, Isaac P. Witz
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1376-1390 (2021)
Previous studies indicated that microglia cells upregulate the expression of aldolase C (ALDOC) in melanoma cells. The present study using brain‐metastasizing variants from three human melanomas explores the functional role of ALDOC in the formatio
Externí odkaz:
https://doaj.org/article/6395e751f428401dba0b175e165734b4
Autor:
Romela Irene Ramos, Matias A. Bustos, Jinfeng Wu, Peter Jones, Shu Ching Chang, Eiji Kiyohara, Kevin Tran, Xiaoqing Zhang, Stacey L. Stern, Sivan Izraely, Orit Sagi‐Assif, Isaac P. Witz, Michael A. Davies, Gordon B. Mills, Daniel F. Kelly, Reiko F. Irie, Dave S. B. Hoon
Publikováno v:
Molecular Oncology, Vol 14, Iss 8, Pp 1760-1778 (2020)
Melanoma metastasis to the brain is one of the most frequent extracranial brain tumors. Cell surface gangliosides are elevated in melanoma metastasis; however, the metabolic regulatory mechanisms that govern these specific changes are poorly understo
Externí odkaz:
https://doaj.org/article/f837254cc4fc4a5eba73e3a62e629a8c
Autor:
Xiaoqing Zhang, Matias A. Bustos, Rebecca Gross, Romela Irene Ramos, Teh‐Ling Takeshima, Gordon B. Mills, Qiang Yu, Dave S. B. Hoon
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 10, Pp n/a-n/a (2021)
Abstract Background 1q21.3 amplification, which is frequently observed in metastatic melanoma, is associated with cancer progression. Interleukin enhancer‐binding factor 2 (ILF2) is located in the 1q21.3 amplified region, but its functional role or
Externí odkaz:
https://doaj.org/article/93d85c4fa77046069f2a1780c2d10ba8
Autor:
Yoko Koh, Matias A. Bustos, Jamie Moon, Rebecca Gross, Romela Irene Ramos, Suyeon Ryu, Jane Choe, Selena Y. Lin, Warren M. Allen, David L. Krasne, Timothy G. Wilson, Dave S. B. Hoon
Publikováno v:
Cancers, Vol 14, Iss 10, p 2388 (2022)
Prostate cancer (PCa) is the most common cancer in men. Prostate-specific antigen screening is recommended for the detection of PCa. However, its specificity is limited. Thus, there is a need to find more reliable biomarkers that allow non-invasive s
Externí odkaz:
https://doaj.org/article/a3798275b9c44071b3d762f5061b7285
Autor:
Xiaoqing Zhang, Matias A. Bustos, Yoshiaki Shoji, Romela Irene Ramos, Yuuki Iida, Rebecca Gentry, Teh-Ling Takeshima, Dave S. B. Hoon
Publikováno v:
Cancers, Vol 13, Iss 18, p 4691 (2021)
The role of post-translational modifications (PTM) of the key epigenetic factor DNMT1 protein has not been well explored in cutaneous metastatic melanoma progression. The acetylated DNMT1 (ac-DNMT1) protein level was assessed using an anti-acetylated
Externí odkaz:
https://doaj.org/article/fbbdec72ff2f45a183916808ae1863d7
Hypomethylation of CNTFRα is associated with proliferation and poor prognosis in lower grade gliomas
Autor:
Kun Fan, Xiaowen Wang, Jingwen Zhang, Romela Irene Ramos, Haibo Zhang, Chunjie Li, Dan Ye, Jiansheng Kang, Diego M. Marzese, Dave S. B. Hoon, Wei Hua
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Ciliary neurotrophic factor receptor α subunit (CNTFRα) and CNTF play important roles in neuron survival, glial differentiation and brain tumor growth. However, the molecular mechanisms of CNTFRα regulation and its clinical significance i
Externí odkaz:
https://doaj.org/article/4caaa1c465b54501b3314f2f0aad6ec5
Autor:
Romela Irene Ramos, Misa A. Shaw, Leland Foshag, Stacey L. Stern, Negin Rahimzadeh, David Elashoff, Dave S. B. Hoon
Publikováno v:
Cancers, Vol 13, Iss 1, p 91 (2020)
Adjuvant immunotherapy in melanoma patients improves clinical outcomes. However, success is unpredictable due to inherited heterogeneity of immune responses. Inherent immune genes associated with single nucleotide polymorphisms (SNPs) may influence a
Externí odkaz:
https://doaj.org/article/912acfdf3ac8418d807a84d9ddd77397
Autor:
Xiaowen Wang, Matias A. Bustos, Xiaoqing Zhang, Romela Irene Ramos, Cong Tan, Yuuki Iida, Shu-Ching Chang, Matthew P. Salomon, Kevin Tran, Rebecca Gentry, Yelena Kravtsova-Ivantsiv, Daniel F. Kelly, Gordon B. Mills, Aaron Ciechanover, Ying Mao, Dave S.B. Hoon
Publikováno v:
Cancers, Vol 12, Iss 5, p 1081 (2020)
This study examined the role of the ubiquitin E3-ligase RNF123 in modulating downstream NF-κB1 targets in glioblastoma (GB) tumor progression. Our findings revealed an oncogenic pathway (miR-155-5p-RNF123-NF-κB1-p50-SerpinE1) that may represent a n
Externí odkaz:
https://doaj.org/article/7994886cfc5240eeae22e6f6f37f35cb
Autor:
Anna M. Leung, Agnes Fermin Lee, Junko eOzao-Choy, Romela Irene Ramos, Omid eHamid, Steven J. O'Day, Myung eShin-Sim, Donald L. Morton, Mark B. Faries, Peter A. Sieling, Delphine J Lee
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
Stage IV metastatic melanoma patients historically have a poor prognosis with 5-10% 5-year survival. Ipilimumab, a monoclonal antibody against cytotoxic T-lymphocyte antigen 4 (CTLA4), is one of the first treatments to provide beneficial durable resp
Externí odkaz:
https://doaj.org/article/f38a13bb96e14ad0886b8e5acf0e9c61
Autor:
Jared A Niska, Jeffrey A Meganck, Jonathan R Pribaz, Jonathan H Shahbazian, Ed Lim, Ning Zhang, Brad W Rice, Ali Akin, Romela Irene Ramos, Nicholas M Bernthal, Kevin P Francis, Lloyd S Miller
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47397 (2012)
BackgroundRecent advances in non-invasive optical, radiographic and μCT imaging provide an opportunity to monitor biological processes longitudinally in an anatomical context. One particularly relevant application for combining these modalities is t
Externí odkaz:
https://doaj.org/article/7516798e99424bcc93ed9e0f9e2897ca