Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.

Autor: Selvarajan I; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio., Kiema M; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio., Huang RT; Department of Medicine, The University of Chicago, IL (R.-T.H., J.L., J.Z., Y.F.)., Li J; Department of Medicine, The University of Chicago, IL (R.-T.H., J.L., J.Z., Y.F.)., Zhu J; Department of Medicine, The University of Chicago, IL (R.-T.H., J.L., J.Z., Y.F.)., Pölönen P; Institute of Biomedicine, School of Medicine (P.P., M.H.), University of Eastern Finland, Kuopio., Örd T; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio., Õunap K; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio., Godiwala M; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio., Golebiewski AK; Department of Cellular and Molecular Medicine, College of Medicine, The University of Arizona, Tucson (A.K.G., L.K.S., C.E.R.)., Ravindran A; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio., Mäklin K; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio., Toropainen A; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio., Stolze LK; Department of Cellular and Molecular Medicine, College of Medicine, The University of Arizona, Tucson (A.K.G., L.K.S., C.E.R.)., Arce M; Department of Immunology, Genetics and Pathology, Uppsala University, Sweden (M.A., P.U.M.)., Magnusson PU; Department of Immunology, Genetics and Pathology, Uppsala University, Sweden (M.A., P.U.M.)., White S; Faculty of Medical Sciences, Biosciences Institute, Newcastle University, United Kingdom (S.W.)., Romanoski CE; Department of Cellular and Molecular Medicine, College of Medicine, The University of Arizona, Tucson (A.K.G., L.K.S., C.E.R.)., Heinäniemi M; Institute of Biomedicine, School of Medicine (P.P., M.H.), University of Eastern Finland, Kuopio., Laakkonen JP; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio., Fang Y; Department of Medicine, The University of Chicago, IL (R.-T.H., J.L., J.Z., Y.F.)., Kaikkonen MU; A.I. Virtanen Institute for Molecular Sciences (I.S., M.K., T.Ö., K.Õ., M.G., A.R., K.M., A.T., J.P.L., M.U.K.), University of Eastern Finland, Kuopio.

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2024 Jun; Vol. 44 (6), pp. 1330-1345. Date of Electronic Publication: 2024 Apr 11.

Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells.

Autor: Li J; Committee on Molecular Metabolism and Nutrition, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Zhu J; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Gray O; Department of Human Genetics, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Sobreira DR; Department of Human Genetics, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Wu D; Committee on Molecular Metabolism and Nutrition, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Huang RT; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Miao B; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Sakabe NJ; Department of Human Genetics, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Krause MD; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Kaikkonen MU; A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Romanoski CE; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA., Nobrega MA; Department of Human Genetics, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Fang Y; Committee on Molecular Metabolism and Nutrition, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.; Committee on Molecular Medicine, The University of Chicago, Chicago, IL, USA.

Publikováno v: The Journal of cell biology [J Cell Biol] 2024 Mar 04; Vol. 223 (3). Date of Electronic Publication: 2024 Jan 17.

Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2

Autor: K Chella Krishnan, Vergnes L, Acin-Perez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Peterfy M, Romanoski CE, Reue K, Bjorkegren JLM, Laakso M, Liesa M, Lusis AJ

Publikováno v: Yearbook of Paediatric Endocrinology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7656341d19a07a263bc74652e27ea33e
https://doi.org/10.1530/ey.19.15.17

Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood

Autor: Kariotis, S, Jammeh, E, Swietlik, EM, Pickworth, JA, Rhodes, CJ, Otero, P, Wharton, J, Iremonger, J, Dunning, MJ, Pandya, D, Mascarenhas, TS, Errington, N, Thompson, AAR, Romanoski, CE, Rischard, F, Garcia, JGN, Yuan, JX-J, An, T-HS, Desai, AA, Coghlan, G, Lordan, J, Corris, PA, Howard, LS, Condliffe, R, Kiely, DG, Church, C, Pepke-Zaba, J, Toshner, M, Wort, S, Gräf, S, Morrell, NW, Wilkins, MR, Lawrie, A, Wang, D, Bleda, M, Hadinnapola, C, Haimel, M, Auckland, K, Tilly, T, Martin, JM, Yates, K, Treacy, CM, Day, M, Greenhalgh, A, Shipley, D, Peacock, AJ, Irvine, V, Kennedy, F, Moledina, S, MacDonald, L, Tamvaki, E, Barnes, A, Cookson, V, Chentouf, L, Ali, S, Othman, S, Ranganathan, L, Gibbs, JSR, DaCosta, R, Pinguel, J, Dormand, N, Parker, A, Stokes, D, Ghedia, D, Tan, Y, Ngcozana, T, Wanjiku, I, Polwarth, G, Mackenzie Ross, RV, Suntharalingam, J, Grover, M, Kirby, A, Grove, A, White, K, Seatter, A, Creaser-Myers, A, Walker, S, Roney, S, Elliot, CA, Charalampopoulos, A, Sabroe, I, Hameed, A, Armstrong, I, Hamilton, N, Rothman, AMK, Swift, AJ, Wild, JM, Soubrier, F, Eyries, M, Humbert, M, Montani, D, Girerd, B, Scelsi, L, Ghio, S, Gall, H, Ghofrani, A, Bogaard, HJ, Noordegraaf, AV, Houweling, AC, Veld, AHI, Schotte, G

Idiopathic pulmonary arterial hypertension (IPAH) is a rare but fatal disease diagnosed by right heart catheterisation and the exclusion of other forms of pulmonary arterial hypertension, producing a heterogeneous population with varied treatment res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::54d642bd341cee9decc1a0bef54e4884
https://eprints.gla.ac.uk/260156/1/260156.pdf

Transcriptional drifts associated with environmental changes in endothelial cells.

Autor: Afshar Y; Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, United States.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, United States., Ma F; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, United States.; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States., Quach A; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States., Jeong A; Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, United States., Sunshine HL; Department of Molecular, Cellular and Integrative Physiology, University of California, Los Angeles, Los Angeles, United States.; Department of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, United States., Freitas V; Departament of Cell and Developmental Biology, Institute of Biomedical Science, University of Sao Paulo, Los Angeles, United States., Jami-Alahmadi Y; Department of Biological Chemistry, University of California, Los Angeles, United States., Helaers R; Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium., Li X; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, United States., Pellegrini M; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, United States.; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States., Wohlschlegel JA; Department of Biological Chemistry, University of California, Los Angeles, United States., Romanoski CE; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, United States., Vikkula M; Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium.; WELBIO department, WEL Research Institute, Wavre, Belgium., Iruela-Arispe ML; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.; Department of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, United States.

Publikováno v: ELife [Elife] 2023 Mar 27; Vol. 12. Date of Electronic Publication: 2023 Mar 27.