Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Romano Di-Fabio"'
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100654- (2022)
An efficient synthetic route was set up to prepare in good scale M-108, a novel bicycle derivative recently identified as a potent and selective G9a inhibitor, potentially useful as anti-fibroadipogenic agent. In particular, a facile three-steps sequ
Externí odkaz:
https://doaj.org/article/541b77a011324d9aa43adcccd223c3a1
Autor:
Alessia Petrocchi, Alessandro Grillo, Luca Ferrante, Pietro Randazzo, Adolfo Prandi, Marilenia De Matteo, Costanza Iaccarino, Monica Bisbocci, Antonella Cellucci, Cristina Alli, Martina Nibbio, Vincenzo Pucci, Jérôme Amaudrut, Christian Montalbetti, Carlo Toniatti, Romano Di Fabio
Publikováno v:
ACS Medicinal Chemistry Letters. 14:645-651
Autor:
Leda Ivanova Bencheva, Lorena Donnici, Luca Ferrante, Adolfo Prandi, Roberta Sinisi, Marilenia De Matteo, Pietro Randazzo, Matteo Conti, Pietro Di Lucia, Elisa Bono, Leonardo Giustini, Maria Vittoria Orsale, Alexandros Patsilinakos, Edith Monteagudo, Matteo Iannacone, Vincenzo Summa, Luca G. Guidotti, Raffaele De Francesco, Romano Di Fabio
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
Chronic hepatitis B (CHB) is a major worldwide public health problem and novel anti-HBV therapies preventing liver disease progression to cirrhosis and hepatocellular carcinoma are urgently needed. Over the last several years, capsid assembly modulat
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1114-1120 (2014)
Several strategies aimed to “freeze” natural amino acids into more constrained analogues have been developed with the aim of enhancing in vitro potency/selectivity and, more in general, drugability properties. The case of L-glutamic acid (L-Glu,
Externí odkaz:
https://doaj.org/article/704b657ed2f44d7da97cee6b38392d3a
Autor:
Romano Di Fabio, Matteo Iannacone, Leda Bencheva, Matteo Conti, Katherine Squires, Mark Lockwood, Raffaele De Francesco, Luca Guidotti
Publikováno v:
Journal of Hepatology. 77:S97-S98
Autor:
Pietro Randazzo, Roberta Sinisi, Davide Gornati, Stefania Bertuolo, Leda Bencheva, Marilenia De Matteo, Martina Nibbio, Edith Monteagudo, Lorenzo Turcano, Valeria Bianconi, Giovanna Peruzzi, Vincenzo Summa, Alberto Bresciani, Chiara Mozzetta, Romano Di Fabio
Publikováno v:
Bioorganicmedicinal chemistry letters. 72
A new series of in vitro potent and highly selective histone methyl transferase enzyme G9a inhibitors was obtained. In particular, compound 2a, one the most potent G9a inhibitor identified, was endowed with >130-fold selectivity over GLP and excellen
Autor:
Luca Ferrante, Romano Di Fabio, Federica Poggialini, Maurizio Botta, Vincenzo Summa, Claudio Zamperini, Matteo Borgini
Publikováno v:
ACS Med Chem Lett
[Image: see text] The marine natural product Largazole is the most potent Class I HDAC inhibitor identified to date. Since its discovery, many research groups have been attracted by the structural complexity and the peculiar anticancer activity, due
Autor:
Tiziana Santini, Romano Di Fabio, Valeria Bianconi, Fabrizia Marullo, Giovanna Peruzzi, Daniel Fernandez Perez, Diego Pasini, Stefano Biagioni, Carlo Toniatti, Vincenzo Summa, Beatrice Biferali, Federica Polverino, Roberta Maggio, Sigmar Stricker, Chiara Mozzetta, Sophie Pöhle Kronawitter, Fulvio Chiacchiera
Publikováno v:
Science Advances
A druggable mechanism is found to reprogram fibro-adipogenic progenitors toward myogenesis and to improve muscle repair.
H3K9 methylation maintains cell identity orchestrating stable silencing and anchoring of alternate fate genes within the het
H3K9 methylation maintains cell identity orchestrating stable silencing and anchoring of alternate fate genes within the het
Publikováno v:
ChemMedChem. 12:1917-1926
Since the time of its identification, the natural compound largazole rapidly caught the attention of the medicinal chemistry community for its impressive potency as an inhibitor of histone deacetylases (HDACs) and its strong antiproliferative activit
Autor:
Adolfo Prandi, Luca Ferrante, Maria Veneziano, Mariana Gallo, Marco Ferrara, Leda Ivanova Bencheva, Antonella Cellucci, Nausicaa Mazzocchi, Pierfausto Seneci, Silvano Ronzoni, Andrea Menegon, Roberta Sinisi, Pietro Randazzo, Vincenzo Summa, Marilenia De Matteo, Romano Di Fabio
[Image: see text] Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8a3bad6284485d88304e25bccd2e07
http://hdl.handle.net/11588/828238
http://hdl.handle.net/11588/828238