Výsledky vyhledávání - "Romana Schäfer"

Persistent plasminogen activator inhibitor 1 gene expression in cardiac transplant recipients with idiopathic dilated cardiomyopathy

Autor: Matthias Gmeiner, Dietmar Abraham, Seyedhossein Aharinejad, Romana Schäfer, Katharina Krenn

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 139(6):1644-1651

Objectives Plasminogen activator inhibitor 1 is the primary regulator of urokinase plasminogen activator and tissue plasminogen activator. Plasminogen activator inhibitor 1 is essential in the control of the thrombotic/fibrinolytic balance and is a m

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Serum Matrix Metalloprotease-1 and Vascular Endothelial Growth Factor-A Predict Cardiac Allograft Rejection

Autor: Seyedhossein Aharinejad, Michael Grimm, Katharina Krenn, B. Schneider, Andreas Zuckermann, Matthias Gmeiner, Anita C Thomas, Romana Schäfer, Arezu Aliabadi

Publikováno v: American Journal of Transplantation. 9:149-159

Cardiac allograft rejection is currently diagnosed from endomyocardial biopsies (EMB) that are invasive and impractical to repeat. A serological marker could facilitate rejection monitoring and minimize EMB-associated risks. We investigated the relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb2345c7079d6be324926a349840242
https://doi.org/10.1111/j.1600-6143.2008.02470.x

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Colony-Stimulating Factor-1 Antibody Reverses Chemoresistance in Human MCF-7 Breast Cancer Xenografts

Autor: Seyedhossein Aharinejad, Dietmar Abraham, E. Richard Stanley, Patrick Paulus, Romana Schäfer

Publikováno v: Cancer Research. 66:4349-4356

Overexpression of colony-stimulating factor-1 (CSF-1) and its receptor in breast cancer is correlated with poor prognosis. Based on the hypothesis that blockade of CSF-1 would be beneficial in breast cancer treatment, we developed a murinized, polyet

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https://doi.org/10.1158/0008-5472.can-05-3523

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Inflammation and postinfarct remodeling: Overexpression of IκB prevents ventricular dilation via increasing TIMP levels

Autor: Seyedhossein Aharinejad, Romana Schäfer, M Gyongyosi, Ernst Wolner, Oliver Y. Bernecker, Barbara Fellner, Bruno K. Podesser, Karola Trescher, Rainer DeMartin

Publikováno v: Cardiovascular Research. 69:746-754

Objective: Nuclear factor-kappa B (NF-κB) orchestrates genes involved in inflammation and extracellular matrix (ECM) remodeling following myocardial infarction (MI). The objective of the present study was to investigate the effect of overexpression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf338b5194f86a66abad4781c41bdfb
https://doi.org/10.1016/j.cardiores.2005.11.027

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Colony-Stimulating Factor-1 Blockade by Antisense Oligonucleotides and Small Interfering RNAs Suppresses Growth of Human Mammary Tumor Xenografts in Mice

Autor: Dietmar Abraham, Romana Schäfer, Michael Hofmann, Karin Zins, Seyedhossein Aharinejad, E. Richard Stanley, Patrick Paulus, Mouldy Sioud

Publikováno v: Cancer Research. 64:5378-5384

Colony-stimulating factor (CSF)-1 is the primary regulator of tissue macrophage production. CSF-1 expression is correlated with poor prognosis in breast cancer and is believed to enhance mammary tumor progression and metastasis through the recruitmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dcea90fa7da77c738016482b255081
https://doi.org/10.1158/0008-5472.can-04-0961

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NAB2, a Corepressor of EGR-1, Inhibits Vascular Endothelial Growth Factor-mediated Gene Induction and Angiogenic Responses of Endothelial Cells

Autor: Gernot Schabbauer, Erhard Hofer, Bernd R. Binder, Alexandra Kadl, Matthias Clauss, Horst Dietmar Müller, Diana Mechtcheriakova, Yuri Koshelnick, Katja Issbrücker, Romana Schäfer, Markus Lucerna, Florian Gruber

Publikováno v: Journal of Biological Chemistry. 278:11433-11440

In this study we have investigated the role of a specific corepressor of EGR-1, NAB2, to down-regulate vascular endothelial growth factor (VEGF)-induced gene expression in endothelial cells and to inhibit angiogenesis. Firstly, we show a reciprocal r

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https://doi.org/10.1074/jbc.m204937200

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IMPACT OF CARDIAC TRANSPLANTATION ON MOLECULAR PATHOLOGY OF ET-1, VEGF-C, AND MITOCHONDRIAL METABOLISM AND MORPHOLOGY IN DILATED VERSUS ISCHEMIC CARDIOMYOPATHIC PATIENTS1

Autor: Hannes Traxler, Roland Blumer, G. Laufer, Romana Schäfer, Alfred Kocher, Seyedhossein Aharinejad, Aurelia Miksovsky, D. Pullirsch, Shahrokh Taghavi, Reinhold Hofbauer, Dietmar Abraham, Alexandrowicz R

Publikováno v: Transplantation. 72:1043-1049

Little is known about the long-term impact of cardiac transplantation on activity and modifications of endothelin (ET)-1 system, vascular endothelial growth factor (VEGF), and mitochondrial metabolism and morphology in patients with ischemic cardiomy

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https://doi.org/10.1097/00007890-200109270-00011

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A Human Common Nuclear Matrix Protein Homologous to Eukaryotic Translation Initiation Factor 4A

Autor: Georg Sauermann, Christian Ensinger, Angelika Pöltl, Klaus Holzmann, Christopher Gerner, Rudolf Grimm, Peter Obrist, Romana Schäfer

Publikováno v: Biochemical and Biophysical Research Communications. 267:339-344

Amino acid sequencing and mass spectrometry revealed identity of a human nuclear matrix protein, termed hNMP 265, with a predicted protein of gene KIAA0111. Two-dimensional electrophoresis and Northern hybridization showed the protein to ubiquitously

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https://doi.org/10.1006/bbrc.1999.1973

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Stromal cell-derived CSF-1 blockade prolongs xenograft survival of CSF-1-negative neuroblastoma

Autor: Trevor Lucas, Dietmar Abraham, Karin Zins, Romana Schäfer, E. Richard Stanley, Mouldy Sioud, Seyedhossein Aharinejad

Publikováno v: International Journal of Cancer.

The molecular mechanisms of tumor-host interactions that render neuroblastoma (NB) cells highly invasive are unclear. Cancer cells upregulate host stromal cell colony-stimulating factor-1 (CSF-1) production to recruit tumor-associated macrophages (TA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449a5de2ea15f759722269299001abe5
https://doi.org/10.1002/ijc.24859

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