Selection of scFv Antibody Fragments Binding to Human Blood versus Lymphatic Endothelial Surface Antigens by Direct Cell Phage Display.

Autor: Thomas Keller, Romana Kalt, Ingrid Raab, Helga Schachner, Corina Mayrhofer, Dontscho Kerjaschki, Brigitte Hantusch

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0127169 (2015)

The identification of marker molecules specific for blood and lymphatic endothelium may provide new diagnostic tools and identify new targets for therapy of immune, microvascular and cancerous diseases. Here, we used a phage display library expressin

Externí odkaz: https://doaj.org/article/bcebd6a0346e4db8ad4cc21ad68964d1

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

Autor: Satoshi Hirakawa, Katharina Krautgasser, Ingrid Raab, Felix Offner, Nicole Huttary, Brigitte Hantusch, Romana Kalt, Hitonari Nosaka, Katalin Nagy-Bojarszky, Susanne Wolbank, Klaus Kaserer, Michael Gnant, Katharina Viola, Sigurd Krieger, Helga Schachner, Sybille Madlener, Michael Detmar, Thomas Keller, Karin Lackner, Margaretha Rudas, Veronika Sexl, Martin Schreiber, Gregor Bartel, Thorsten J. Maier, Sandra Rezar, Georg Krupitza, Alexander Nader, Kari Alitalo, Agnes Davidovits, Sebastian M.B. Nijman, Dieter Steinhilber, Christine Schneckenleithner, Wolfgang Mikulits, Dontscho Kerjaschki, Zsuzsanna Bago-Horvath, Caroline Vonach, Monika Hämmerle, Helmut Dolznig

Publikováno v: Kerjaschki, D, Bago-Horvath, Z, Rudas, M, Sexl, V, Schneckenleithner, C, Wolbank, S, Bartel, G, Krieger, S, Kalt, R, Hantusch, B, Keller, T, Nagy-Bojarszky, K, Huttary, N, Raab, I, Lackner, K, Krautgasser, K, Schachner, H, Kaserer, K, Rezar, S, Madlener, S, Vonach, C, Davidovits, A, Nosaka, H, Hämmerle, M, Viola, K, Dolznig, H, Schreiber, M, Nader, A, Mikulits, W, Gnant, M, Hirakawa, S, Detmar, M, Alitalo, K, Nijman, S, Offner, F, Maier, T, Steinhilber, D & Krupitza, G 2011, ' Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse ', Journal of Clinical Investigation, vol. 121, no. 5, pp. 2000-12 . https://doi.org/10.1172/JCI44751

In individuals with mammary carcinoma, the most relevant prognostic predictor of distant organ metastasis and clinical outcome is the status of axillary lymph node metastasis. Metastases form initially in axillary sentinel lymph nodes and progress vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af8be4a35185fe0d6b517ce528129b6
https://doi.org/10.1172/jci44751

Tumor-Associated Macrophages Express Lymphatic Endothelial Growth Factors and Are Related to Peritumoral Lymphangiogenesis

Autor: Carola Caucig, Romana Kalt, Katalin Nagy, Peter Birner, Dontscho Kerjaschki, Ernst Kriehuber, Robert Ullrich, Kari Alitalo, Johannes Stöckl, Sebastian F. Schoppmann

Publikováno v: The American Journal of Pathology. 161:947-956

Formation of lymphatic metastasis is the initial step of generalized spreading of tumor cells and predicts poor clinical prognosis. Lymphatic vessels generally arise within the peritumoral stroma, although the lymphangiopoietic vascular endothelial g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80446d7136113a237f01d5b0e22d509e
https://doi.org/10.1016/s0002-9440(10)64255-1

Telomerase-immortalized lymphatic and blood vessel endothelial cells are functionally stable and retain their lineage specificity

Autor: Sebastian F. Schoppmann, Christian Benisch, Usha Nagavarapu, Silvana Geleff, Romana Kalt, G. Scott Herron, Afschin Soleiman, Yukari Okubo

Publikováno v: Microcirculation (New York, N.Y. : 1994). 11(3)

Microvasculature plays an important role in a variety of physiological and pathological processes. The authors have previously shown that primary cultures of human microvascular endothelial cells consist of 2 distinct populations of blood vascular an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ce82f53c3d8d1eafb06ec32df60741
https://pubmed.ncbi.nlm.nih.gov/15280080

Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cells.

Autor: Hantusch, Brigitte¹ brigitte.hantusch@meduniwien.ac.at, Kalt, Romana¹ romana.kalt@meduniwien.ac.at, Krieger, Sigurd¹ sigurd.krieger@meduniwien.ac.at, Puri, Christina¹ christina.puri@meduniwien.ac.at, Kerjaschki, Dontscho¹ dontscho.kerjaschki@meduniwien.ac.at

Publikováno v: BMC Molecular Biology. 2007, Vol. 8, p20-24. 24p. 5 Diagrams, 1 Chart, 5 Graphs.