Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma.

Autor: Pontarini E; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Murray-Brown WJ; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Croia C; Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Lucchesi D; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Conway J; Oncology R&D, Astrazeneca, Gaithersburg, Maryland, USA., Rivellese F; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Fossati-Jimack L; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Astorri E; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Prediletto E; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Corsiero E; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Romana Delvecchio F; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Coleby R; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Gelbhardt E; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Bono A; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Baldini C; University of Pisa, Rheumatology Unit, Pisa, PI, Italy., Puxeddu I; Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Ruscitti P; Department of Clinical Sciences and Applied Biotechnology, University of L'Aquila, L'Aquila, Abruzzo, Italy., Giacomelli R; Department of Clinical Sciences and Applied Biotechnology, University of L'Aquila, L'Aquila, Abruzzo, Italy., Barone F; RRG, Institute of Inflamation and Ageing, University of Birmingham, Birmingham, UK, UK.; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Fisher B; RRG, Institute of Inflamation and Ageing, University of Birmingham, Birmingham, UK, UK.; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Bowman SJ; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Colafrancesco S; Dipartimento di Medicina Interna e Specilità Mediche, UOC Reumatologia, Universita degli Studi di Roma La Sapienza Facolta di Medicina e Odontoiatria, Roma, Lazio, Italy., Priori R; Dipartimento di Medicina Interna e Specilità Mediche, UOC Reumatologia, Universita degli Studi di Roma La Sapienza Facolta di Medicina e Odontoiatria, Roma, Lazio, Italy., Sutcliffe N; Rheumatology, Barts Health NHS Trust, London, London, UK., Challacombe S; Oral Medicine, KCL Dental Institute, London, UK., Carlesso G; Early ICA Discovery, Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland, USA., Tappuni A; Institute of Dentistry, Barts and The London School of Medicine and Dentistry, London, London, UK., Pitzalis C; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK., Bombardieri M; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, England, UK m.bombardieri@qmul.ac.uk.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2020 Dec; Vol. 79 (12), pp. 1588-1599. Date of Electronic Publication: 2020 Sep 22.

Lymphocyte subpopulations in Sjögren's syndrome are distinct in anti-SSA-positive patients and related to disease activity.

Autor: Barcelos, Filipe, Martins, Catarina, Madeira, Nathalie, Ângelo-Dias, Miguel, Cardigos, Joana, Alves, Nuno, Vaz-Patto, José, Cunha-Branco, Jaime, Borrego, Luís-Miguel

Publikováno v: Clinical Rheumatology; Jul2021, Vol. 40 Issue 7, p2791-2804, 14p