Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Romana, Schober"'
Autor:
Christine Silvia Gibhardt, Sabrina Cappello, Rajesh Bhardwaj, Romana Schober, Sonja Agnes Kirsch, Zuriñe Bonilla del Rio, Stefan Gahbauer, Anna Bochicchio, Magdalena Sumanska, Christian Ickes, Ioana Stejerean-Todoran, Miso Mitkovski, Dalia Alansary, Xin Zhang, Aram Revazian, Marc Fahrner, Victoria Lunz, Irene Frischauf, Ting Luo, Daria Ezerina, Joris Messens, Vsevolod Vadimovich Belousov, Markus Hoth, Rainer Arnold Böckmann, Matthias Albrecht Hediger, Rainer Schindl, Ivan Bogeski
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108292- (2020)
Summary: Store-operated calcium entry (SOCE) through STIM-gated ORAI channels governs vital cellular functions. In this context, SOCE controls cellular redox signaling and is itself regulated by redox modifications. However, the molecular mechanisms
Externí odkaz:
https://doaj.org/article/9aa210ab347a4829a53ce714c6a1e9f1
Autor:
Matthias Sallinger, Adéla Tiffner, Tony Schmidt, Daniel Bonhenry, Linda Waldherr, Irene Frischauf, Victoria Lunz, Isabella Derler, Romana Schober, Rainer Schindl
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4410 (2020)
Stromal interaction molecule 1 (STIM1) is a ubiquitously expressed Ca2+ sensor protein that induces permeation of Orai Ca2+ channels upon endoplasmic reticulum Ca2+-store depletion. A drop in luminal Ca2+ causes partial unfolding of the N-terminal ST
Externí odkaz:
https://doaj.org/article/fb9d8fc255c8464eb92a6f2a72999084
Autor:
Derler, Adéla Tiffner, Valentina Hopl, Romana Schober, Matthias Sallinger, Herwig Grabmayr, Carmen Höglinger, Marc Fahrner, Victoria Lunz, Lena Maltan, Irene Frischauf, Denis Krivic, Rajesh Bhardwaj, Rainer Schindl, Matthias A. Hediger, Isabella
Publikováno v:
Cancers; Volume 13; Issue 24; Pages: 6357
The interplay of SK3, a Ca2+ sensitive K+ ion channel, with Orai1, a Ca2+ ion channel, has been reported to increase cytosolic Ca2+ levels, thereby triggering proliferation of breast and colon cancer cells, although a molecular mechanism has remained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::060c988f53744e55d7420e9b5ed66718
Autor:
Adéla Tiffner, Valentina Hopl, Romana Schober, Matthias Sallinger, Herwig Grabmayr, Carmen Höglinger, Marc Fahrner, Victoria Lunz, Lena Maltan, Irene Frischauf, Denis Krivic, Rajesh Bhardwaj, Rainer Schindl, Matthias A. Hediger, Isabella Derler
Publikováno v:
Cancers
Cancers, Vol 13, Iss 6357, p 6357 (2021)
Cancers, Vol 13, Iss 6357, p 6357 (2021)
Simple Summary Breast, colon, and prostate cancer account for about a third of cancer cases and a fifth of cancer deaths. At the molecular level, one reason for the development of cancer is the dysfunction or altered co-regulation of cellular protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::376a4dfd641fd3ab9af406ff793dd821
https://pubmed.ncbi.nlm.nih.gov/34944977
https://pubmed.ncbi.nlm.nih.gov/34944977
Autor:
Vivian Pogenberg, Margret H. Ogmundsdottir, Romana Schober, Morlin Milewski, Agnieszka Obarska-Kosinska, Rainer Schindl, Josué Ballesteros-Álvarez, Matthias Wilmanns, Ingibjörg Sigvaldadóttir, Eiríkur Steingrímsson
Publikováno v:
'Nucleic Acids Research ', vol: 48, pages: 934-948 (2020)
Nucleic Acids Research
Nucleic Acids Research
Interrupted dimeric coiled coil segments are found in a broad range of proteins and generally confer selective functional properties such as binding to specific ligands. However, there is only one documented case of a basic-helix–loop–helix leuci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d49e7c385a7315ecd9f13086ade5f3
https://doi.org/10.1093/nar/gkz1104
https://doi.org/10.1093/nar/gkz1104
Publikováno v:
Seminars in Cell & Developmental Biology. 94:28-39
Canonical members of the TRP superfamily of ion channels have long been recognized as key elements of Ca2+ handling in a plethora of cell types. The emerging role of TRPC channels in human physiopathology has generated considerable interest in their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c73ed48a2670be255b36390333f4d9
https://doi.org/10.1016/j.semcdb.2019.02.001
https://doi.org/10.1016/j.semcdb.2019.02.001
Autor:
Clemens Stilianu, Tony Schmidt, Linda Waldherr, Annarita Graziani, Klaus Groschner, Lorenz Legat, Romana Schober, Rainer Schindl
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:1079-1091
Since calcium (Ca2+) regulates a large variety of cellular signaling processes in a cell's life, precise control of Ca2+ concentrations within the cell is essential. This enables the transduction of information via Ca2+ changes in a time-dependent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d89e0c5b7e1e5b5fe7093a3520ba083b
https://doi.org/10.1016/j.bbamcr.2018.11.001
https://doi.org/10.1016/j.bbamcr.2018.11.001
Autor:
Linda Waldherr, Adela Tiffner, Deepti Mishra, Matthias Sallinger, Romana Schober, Irene Frischauf, Tony Schmidt, Verena Handl, Peter Sagmeister, Manuel Köckinger, Isabella Derler, Muammer Üçal, Daniel Bonhenry, Silke Patz, Rainer Schindl
Publikováno v:
Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2876, p 2876 (2020)
Volume 12
Issue 10
Cancers, Vol 12, Iss 2876, p 2876 (2020)
The Ca2+ sensor STIM1 and the Ca2+ channel Orai1 that form the store-operated Ca2+ (SOC) channel complex are key targets for drug development. Selective SOC inhibitors are currently undergoing clinical evaluation for the treatment of auto-immune and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::99b1cd36bc06f87a37b9eaa53c1546ca
Autor:
Sonja Lindinger, Saurabh Pandey, Adéla Tiffner, Isabella Derler, Michael Stadlbauer, Victoria Lunz, Daniel Bonhenry, Rudi Ettrich, Irene Frischauf, Matthias Sallinger, Marc Fahrner, Christoph Romanin, Lena Maltan, Sascha Berlansky, Rainer Schindl, Romana Schober, Carmen Hoeglinger
The initial activation step in gating of ubiquitously expressed Orai1 Calcium (Ca2+) ion channels represents the store-dependent coupling to the Ca2+ sensor protein STIM1. An array of constitutively active Orai1 mutants gave rise to the hypothesis th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5a605ab39dd19a2e1115dfd3781cef8
https://doi.org/10.1101/2020.07.16.207183
https://doi.org/10.1101/2020.07.16.207183
Autor:
Romana, Schober, Daniel, Bonhenry, Victoria, Lunz, Jinhui, Zhu, Adela, Krizova, Irene, Frischauf, Marc, Fahrner, MengQi, Zhang, Linda, Waldherr, Tony, Schmidt, Isabella, Derler, Peter B, Stathopulos, Christoph, Romanin, Rüdiger H, Ettrich, Rainer, Schindl
Publikováno v:
Science signaling. 12(608)
The stromal interaction molecule 1 (STIM1) has two important functions, Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::335f671397e3f1d355e70d4f9b13bf3c
https://pubmed.ncbi.nlm.nih.gov/31744929
https://pubmed.ncbi.nlm.nih.gov/31744929