Non-canonical ubiquitylation of the proneural protein Ngn2 occurs in both Xenopus embryos and mammalian cells

Autor: Romana Kucerova, Gary S. McDowell, Anna Philpott

Publikováno v: Biochemical and Biophysical Research Communications. 400:655-660

Poly-ubiquitin chains targeting proteins for 26S proteasomal degradation are classically anchored on internal lysines of substrates via iso-peptide linkages. However recently, linkage of ubiquitin moieties to non-canonical nucleophilic residues, such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20ce4e47a6638c0734ef201e658180e
https://doi.org/10.1016/j.bbrc.2010.08.122

Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium

Autor: Romana, Kucerova, Natalie, Dorà, Richard L, Mort, Karen, Wallace, Lucy J, Leiper, Christina, Lowes, Carlos, Neves, Petr, Walczysko, Freyja, Bruce, Paul A, Fowler, Ann M, Rajnicek, Colin D, McCaig, Min, Zhao, John D, West, J Martin, Collinson

Publikováno v: Molecular Vision

Purpose To investigate the roles of intracellular signaling elicited by Hedgehog (Hh) ligands in corneal maintenance and wound healing. Methods The expression of Hedgehog pathway components in the cornea was assayed by immunohistochemistry, western b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::222ae618b2f907a131c9af0ee6351eb9
https://pubmed.ncbi.nlm.nih.gov/22275805

PAX6 Dosage Effects on Corneal Development, Growth, and Wound Healing

Autor: Romana Kucerova, Jingxing Ou, John D. West, Ida Parisi, J. Martin Collinson, Natalie Dora

Publikováno v: Dora, N, Ou, J X, Kucerova, R, Parisi, I, West, J D & Collinson, J M 2008, ' PAX6 dosage effects on comeal development, growth, and wound healing ', Developmental Dynamics, vol. 237, no. 5, pp. 1295-1306 . https://doi.org/10.1002/dvdy.21528

The requirement for correct dosage of the transcription factor Pax6 during corneal growth and development was investigated using the Pax6-overexpressing (PAX77) transgenic mouse. Transgenics had a microcornea phenotype due to failure of postnatal gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41baf17f91000181dc6a6171d869ed9b
https://europepmc.org/articles/PMC2655055/

The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6+/- mouse model of epithelial wound-healing delay

Autor: Diane Lawson, J. Martin Collinson, Lynne Shanley, Lucy J. Leiper, Petr Walczysko, Min Zhao, Romana Kucerova, John V. Forrester, Jingxing Ou, Colin D. McCaig

Publikováno v: BMC Biology, Vol 4, Iss 1, p 27 (2006)
BMC Biology

Background Congenital aniridia caused by heterozygousity at the PAX6 locus is associated with ocular surface disease including keratopathy. It is not clear whether the keratopathy is a direct result of reduced PAX6 gene dosage in the cornea itself, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef12f8c83734e0c3bb8d8d8fdd14752
http://www.biomedcentral.com/1741-7007/4/27

Control of Patterns of Corneal Innervation by Pax6

Autor: Petr Walczysko, John D. West, Romana Kucerova, Lucy J. Leiper, Derek N. Lavery, Jingxing Ou, J. Martin Collinson

Publikováno v: Leiper, L J, Ou, J X, Walczysko, P, Kucerova, R, Lavery, D N, West, J D & Collinson, J M 2009, ' Control of Patterns of Corneal Innervation by Pax6 ', Investigative Ophthalmology & Visual Science, vol. 50, no. 3, pp. 1122-1128 . https://doi.org/10.1167/iovs.08-2812

The transcription factor PAX6 is essential for eye development and is found in several ocular cell types, including the corneal and limbal epithelia, where gene expression is maintained throughout life.1-4 Heterozygous deficiencies in PAX6 are charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d6152c4c540f56712d0543d73247ca
https://doi.org/10.1167/iovs.08-2812