Alarmone Synthesis Inhibition as a New Strategy for Tuberculosis Treatment

Autor: Roman Yu. Sidorov, Ekaterina I. Markelova, Alexander G. Tkachenko

Publikováno v: Science and Global Challenges of the 21st Century – Innovations and Technologies in Interdisciplinary Applications ISBN: 9783031280856

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51d882e255541ca2946fe9815d03044f
https://doi.org/10.1007/978-3-031-28086-3_42

Oak bark (Quercus sp. cortex) protects plants through the inhibition of quorum sensing mediated virulence of Pectobacterium carotovorum

Autor: Alexey S. Vasilchenko, Darya V. Poshvina, Roman Yu. Sidorov, Aleksandr V. Iashnikov, Eugene A. Rogozhin, Anastasia V. Vasilchenko

Publikováno v: World Journal of Microbiology and Biotechnology. 38

Bacterial intercellular communication mediated by small diffusible molecules, known as quorum sensing (QS), is a common mechanism for regulating bacterial colonisation strategies and survival. Influence on QS by plant-derived molecules is proposed as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e842569eb388979b461dcc79d151d24
https://doi.org/10.1007/s11274-022-03366-6

A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases

Autor: Anna V. Akhova, Ivan V. Tsyganov, Andrei V. Malkov, S. A. Shipilovskikh, Aleksandr E. Rubtsov, A. G. Tkachenko, Roman Yu. Sidorov, Larisa Yu. Nesterova, Natalya M. Kashevarova, Vladimir Yu. Vaganov

Publikováno v: Cell chemical biology. 28(10)

Summary Bacterial persistence coupled with biofilm formation is directly associated with failure of antibiotic treatment of tuberculosis. We have now identified 4-(4,7-DiMethyl-1,2,3,4-tetrahydroNaphthalene-1-yl)Pentanoic acid (DMNP), a synthetic dit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedf4e7ed9c9c0490ba46df1482c0453
https://pubmed.ncbi.nlm.nih.gov/33621482