Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Roman W Lutz"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120403 (2015)
Currently, genotyping of patients for polymorphic enzymes responsible for metabolic elimination is considered a possibility to adjust drug dose levels. For a patient to profit from this procedure, the interindividual differences in drug metabolism wi
Externí odkaz:
https://doaj.org/article/326b566bca5b48e2a52f66118939dc0e
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0126329 (2015)
Externí odkaz:
https://doaj.org/article/80b6ba9bc583495f840e85417b1526a0
Publikováno v:
Regulatory Toxicology ISBN: 9783642353734
Regulatory Toxicology ISBN: 9783642362064
Regulatory Toxicology ISBN: 9783642362064
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfeeb8ab99565be879ca108b0e2a8ce
https://doi.org/10.1007/978-3-030-57499-4_72
https://doi.org/10.1007/978-3-030-57499-4_72
Autor:
Roman W. Lutz, Werner K. Lutz
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 678:118-122
Strongly sublinear dose-response relationships (slope increasing with dose) raise the question about a putative threshold dose below which no biologically relevant effect would be expected. A mathematical threshold with a break in the curve at the th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28a8415f99cd93bf22bd08de2e7d8af
https://doi.org/10.1016/j.mrgentox.2009.05.010
https://doi.org/10.1016/j.mrgentox.2009.05.010
Publikováno v:
Computational Statistics & Data Analysis. 52:3331-3341
Five robustifications of L"2 boosting for linear regression with various robustness properties are considered. The first two use the Huber loss as implementing loss function for boosting and the second two use robust simple linear regression for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e30464c7e27ff0ed3f06fbe06914e6c2
https://doi.org/10.1016/j.csda.2007.11.006
https://doi.org/10.1016/j.csda.2007.11.006
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0120403 (2015)
PLoS ONE, 10 (3)
PLoS ONE, Vol 10, Iss 3, p e0120403 (2015)
PLoS ONE, 10 (3)
Currently, genotyping of patients for polymorphic enzymes responsible for metabolic elimination is considered a possibility to adjust drug dose levels. For a patient to profit from this procedure, the interindividual differences in drug metabolism wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73006fd25199e95dd1a38de29c0479f7
Autor:
Peter Bühlmann, Roman W. Lutz
Publikováno v:
Journal of Computational and Graphical Statistics. 15:287-311
Boosting in the context of linear regression has become more attractive with the invention of least angle regression (LARS), where the connection between the lasso and forward stagewise fitting (boosting) has been established. Earlier it has been fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8e1eb7e962f8aa8aa55c11608adca50
https://doi.org/10.1198/106186006x113548
https://doi.org/10.1198/106186006x113548
Publikováno v:
Analytical Chemistry. 78:4564-4571
Mass spectrometry (MS) is increasingly being used for metabolic profiling, but detection modes such as constant neutral loss or multiple reaction monitoring have not often been reported. These modes allow focusing on structurally related compounds, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e6595e520f7b7f706ab8c448b464b1
https://doi.org/10.1021/ac0522299
https://doi.org/10.1021/ac0522299
Publikováno v:
Toxicological Sciences, 89 (1)
Toxicological Sciences, 89 (1)
ISSN:1096-6080
ISSN:1096-0929
ISSN:1096-6080
ISSN:1096-0929
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b382fbf9a317a343de86c5a1d8e4ccc
https://doi.org/10.1093/toxsci/kfj024
https://doi.org/10.1093/toxsci/kfj024
Publikováno v:
Toxicology and Applied Pharmacology. 207:565-569
Nonlinear and threshold-like shapes of dose–response curves are often observed in tests for carcinogenicity. Here, we present three examples where an apparent threshold is spurious and can be misleading for low dose extrapolation and human cancer r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a55c6bee4d4008b4e473fcd71f90224
https://doi.org/10.1016/j.taap.2005.01.038
https://doi.org/10.1016/j.taap.2005.01.038