Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Roman V, Uzhachenko"'
Autor:
Elena E. Tchekneva, Mounika U.L. Goruganthu, Roman V. Uzhachenko, Portia L. Thomas, Anneliese Antonucci, Irina Chekneva, Michael Koenig, Longzhu Piao, Anwari Akhter, Maria Teresa P. de Aquino, Parvathi Ranganathan, Nicholas Long, Thomas Magliery, Anna Valujskikh, Jason V. Evans, Rajeswara R. Arasada, Pierre P. Massion, David P. Carbone, Anil Shanker, Mikhail M. Dikov
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Notch intercellular communication instructs tissue-specific T-cell development and function. In this study, we explored the roles of dendritic cell (DC)-expressed Notch ligands in the regulation of T-cell effector function. Method
Externí odkaz:
https://doaj.org/article/189641300f6645669e1ab821393c6568
Autor:
Roman V. Uzhachenko, Vijaya Bharti, Zhufeng Ouyang, Ashlyn Blevins, Stacey Mont, Nabil Saleh, Hunter A. Lawrence, Chengli Shen, Sheau-Chiann Chen, Gregory D. Ayers, David G. DeNardo, Carlos Arteaga, Ann Richmond, Anna E. Vilgelm
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108944- (2021)
Summary: Inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6i) delay progression of metastatic breast cancer. However, complete responses are uncommon and tumors eventually relapse. Here, we show that CDK4/6i can enhance efficacy of T cell-based t
Externí odkaz:
https://doaj.org/article/79f5d8debd9044078fe632ac824c4fe3
Autor:
Roman V. Uzhachenko, Anil Shanker
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Multiple effector layers in the immune system ensure an optimal temporal and spatial distribution of immune defense. Cytotoxic innate lymphoid natural killers (NK) and adaptive CD8+ T lymphocytes (CTL) interact to elicit specific cytolytic outcomes.
Externí odkaz:
https://doaj.org/article/8cdbc53dd94a45d6bef4c9a3e1637754
Autor:
Elena E. Tchekneva, Mounika U. L. Goruganthu, Roman V. Uzhachenko, Portia L. Thomas, Anneliese Antonucci, Irina Chekneva, Longzhu Piao, Anwari Akhter, Maria Teresa P. de Aquino, Parvathi Ranganathan, Nicholas Long, Thomas Magliery, Anna Valujskikh, Jason V. Evans, Rajeswara R. Arasada, Pierre P. Massion, David P. Carbone, Mikhail M. Dikov
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1 (2019)
Following publication of the original article [1], the author reported the wrong version of Figs. 5 and 7 have been published. The correct version of the figures can be found below:
Externí odkaz:
https://doaj.org/article/62099dc4b801450787bf25f738439385
Autor:
Jason V Evans, Shankar Suman, Mounika Uttam L Goruganthu, Elena E Tchekneva, Shuxiao Guan, Rajeswara Rao Arasada, Anneliese Antonucci, Longzhu Piao, Irina Ilgisonis, Andrey A Bobko, Benoit Driesschaert, Roman V Uzhachenko, Rebecca Hoyd, Alexandre Samouilov, Joseph Amann, Ruohan Wu, Lai Wei, Aaditya Pallerla, Sergey V Ryzhov, Igor Feoktistov, Kyungho P Park, Takefumi Kikuchi, Julio Castro, Alla V Ivanova, Thanigaivelan Kanagasabai, Dwight H Owen, Daniel J Spakowicz, Jay L Zweier, David P Carbone, Sergey V Novitskiy, Valery V Khramtsov, Anil Shanker, Mikhail M Dikov
Publikováno v:
JNCI: Journal of the National Cancer Institute.
Background We investigated the role of A2B-adenosine receptor (A2BAR) in regulating immunosuppressive metabolic stress in the tumor microenvironment (TME). Novel A2BAR antagonist PBF-1129 was tested for anti-tumor activity in animals and evaluated fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91ad4707f6ec3847d982cacb2739d623
https://doi.org/10.1093/jnci/djad091
https://doi.org/10.1093/jnci/djad091
Autor:
Mikhail M. Dikov, Anil Shanker, David P. Carbone, Elena E. Tchekneva, Sergey V. Novitskiy, Jason V. Evans, Rajeswara R. Arasada, Anwari Akhter, Kyungho Park, Roman V. Uzhachenko, Duafalia F. Dudimah, Asel K. Biktasova
Activation of Notch signaling in hematopoietic cells by tumors contributes to immune escape. T-cell defects in tumors can be reversed by treating tumor-bearing mice with multivalent forms of the Notch receptor ligand DLL-1, but the immunologic correl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8715f079b5e35c3061bbfb602d4e0114
https://doi.org/10.1158/0008-5472.c.6508031
https://doi.org/10.1158/0008-5472.c.6508031
Autor:
Mikhail M. Dikov, Anil Shanker, David P. Carbone, Elena E. Tchekneva, Sergey V. Novitskiy, Jason V. Evans, Rajeswara R. Arasada, Anwari Akhter, Kyungho Park, Roman V. Uzhachenko, Duafalia F. Dudimah, Asel K. Biktasova
Primers used for qRT-PCR in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1010dd6d6e6c33bdfc20a886a34b72f4
https://doi.org/10.1158/0008-5472.22410617
https://doi.org/10.1158/0008-5472.22410617
Autor:
Mikhail M. Dikov, Anil Shanker, David P. Carbone, Elena E. Tchekneva, Sergey V. Novitskiy, Jason V. Evans, Rajeswara R. Arasada, Anwari Akhter, Kyungho Park, Roman V. Uzhachenko, Duafalia F. Dudimah, Asel K. Biktasova
Clustered DLL1 triggers Notch downstream target genes in cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1240921e7993068051d992e474721464
https://doi.org/10.1158/0008-5472.22410620
https://doi.org/10.1158/0008-5472.22410620
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
Externí odkaz:
https://doaj.org/article/23b9a4e926bf4043a84c16a1afa31663
Autor:
Portia L. Thomas, Mikhail M. Dikov, Longzhu Piao, Parvathi Ranganathan, Anneliese Antonucci, Maria Teresa P. de Aquino, David P. Carbone, Anwari Akhter, Roman V. Uzhachenko, Michael J. Koenig, Rajeswara Rao Arasada, I S Chekneva, Jason V. Evans, Nicholas E. Long, Pierre P. Massion, Thomas J. Magliery, Anna Valujskikh, Elena E. Tchekneva, Mounika U.L. Goruganthu, Anil Shanker
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Background Notch intercellular communication instructs tissue-specific T-cell development and function. In this study, we explored the roles of dendritic cell (DC)-expressed Notch ligands in the regulation of T-cell effector function. Methods We gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18336c6dc13c8f2708b1f3a817ece8cb
http://link.springer.com/article/10.1186/s40425-019-0566-4
http://link.springer.com/article/10.1186/s40425-019-0566-4