Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Roman Szabo"'
Autor:
Elodie Ehret, Sévan Stroh, Muriel Auberson, Frédérique Ino, Yannick Jäger, Marc Maillard, Roman Szabo, Thomas H. Bugge, Simona Frateschi, Edith Hummler
Publikováno v:
Cells, Vol 12, Iss 19, p 2342 (2023)
The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC in vivo. The present study tested whether CAP3/St14 is relevant fo
Externí odkaz:
https://doaj.org/article/c6b5a932c8c94f73bb776dd9d47fb1a1
Publikováno v:
Biology Open, Vol 11, Iss 7 (2022)
Epithelial cell adhesion molecule (EPCAM) is a transmembrane glycoprotein expressed on the surface of most epithelial and epithelium-derived tumor cells and reported to regulate stability of epithelial tight junction proteins, claudins. Despite its w
Externí odkaz:
https://doaj.org/article/4dfbe5dc6ab74460acd3e49311dab94d
Autor:
Elodie Ehret, Yannick Jäger, Chloé Sergi, Anne-Marie Mérillat, Thibaud Peyrollaz, Deepika Anand, Qing Wang, Fréderique Ino, Marc Maillard, Stephan Kellenberger, Ivan Gautschi, Roman Szabo, Thomas H. Bugge, Lotte K. Vogel, Edith Hummler, Simona Frateschi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6745 (2022)
The serine protease prostasin (CAP1/Prss8, channel-activating protease-1) is a confirmed in vitro and in vivo activator of the epithelial sodium channel ENaC. To test whether proteolytic activity or CAP1/Prss8 abundance itself are required for ENaC a
Externí odkaz:
https://doaj.org/article/1cc4224e73f845d493dd991c918734ff
Autor:
Roman Szabo, Thomas H Bugge
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194660 (2018)
Prostasin (CAP1/PRSS8) is a glycosylphosphatidylinositol (GPI)-anchored serine protease that is essential for epithelial development and overall survival in mice. Prostasin is regulated primarily by the transmembrane serine protease inhibitor, hepato
Externí odkaz:
https://doaj.org/article/a9c397b743de4dbaa026a5a133650439
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004470 (2014)
The development of eutherian mammalian embryos is critically dependent on the selective bi-directional transport of molecules across the placenta. Here, we uncover two independent and partially redundant protease signaling pathways that include the m
Externí odkaz:
https://doaj.org/article/d640fb5de5074cefa0ceb6170e674ca5
Autor:
Roman Szabo, Katiuchia Uzzun Sales, Peter Kosa, Natalia A Shylo, Sine Godiksen, Karina K Hansen, Stine Friis, J Silvio Gutkind, Lotte K Vogel, Edith Hummler, Eric Camerer, Thomas H Bugge
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002937 (2012)
Loss of either hepatocyte growth factor activator inhibitor (HAI)-1 or -2 is associated with embryonic lethality in mice, which can be rescued by the simultaneous inactivation of the membrane-anchored serine protease, matriptase, thereby demonstratin
Externí odkaz:
https://doaj.org/article/9de82db345fb45cea6db9244198f55ad
Autor:
Katiuchia Uzzun Sales, John P Hobson, Rebecca Wagenaar-Miller, Roman Szabo, Amber L Rasmussen, Alexandra Bey, Maham F Shah, Alfredo A Molinolo, Thomas H Bugge
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23261 (2011)
Genome mining at the turn of the millennium uncovered a new family of type II transmembrane serine proteases (TTSPs) that comprises 17 members in humans and 19 in mice. TTSPs phylogenetically belong to one of four subfamilies: matriptase, hepsin/TMPR
Externí odkaz:
https://doaj.org/article/e7c0670a36374c32a94c09b4c05ff719
Autor:
Roman Szabo, Mihaela Dinu, Dumitras, Adelina, Mircea, Diana-Maria, Doroftei, Dana, Sestras, Paul, Boscaiu, Monica, Brzuszek, Robert F., Sestras, Adriana F.
Publikováno v:
Frontiers in Psychology; 2023, p1-20, 20p
Publikováno v:
Journal of Horticulture, Forestry & Biotechnology; 2023, Vol. 27 Issue 4, p73-85, 13p
Autor:
Daniel Essigke, Bernhard N. Bohnert, Andrea Janessa, Matthias Wörn, Kingsley Omage, Hubert Kalbacher, Andreas L. Birkenfeld, Thomas H. Bugge, Roman Szabo, Ferruh Artunc
Publikováno v:
Pflugers Arch. 474, 613-624 (2022)
Experimental nephrotic syndrome leads to activation of the epithelial sodium channel (ENaC) by proteolysis and promotes renal sodium retention. The membrane-anchored serine protease prostasin (CAP1/PRSS8) is expressed in the distal nephron and partic