Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Roman Shirokov"'
Autor:
Roman Shirokov, Alexandra V. Ulyanova
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194980 (2018)
Voltage-dependent inward currents responsible for the depolarizing phase of action potentials were characterized in smooth muscle cells of 4thorder arterioles in mouse skeletal muscle. Currents through L-type Ca2+channels were expected to be dominant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c474c880fb74e552b07a24c93866d2
https://doi.org/10.1101/211540
https://doi.org/10.1101/211540
Publikováno v:
The Journal of General Physiology
Using the lanthanide gadolinium (Gd(3+)) as a Ca(2+) replacing probe, we investigated the voltage dependence of pore blockage of Ca(V)1.2 channels. Gd(+3) reduces peak currents (tonic block) and accelerates decay of ionic current during depolarizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28af5a3a107ce573289084126aafdc32
https://doi.org/10.1085/jgp.200709733
https://doi.org/10.1085/jgp.200709733
Publikováno v:
Journal of General Physiology. 129:477-483
Lanthanide gadolinium (Gd(3+)) blocks Ca(V)1.2 channels at the selectivity filter. Here we investigated whether Gd(3+) block interferes with Ca(2+)-dependent inactivation, which requires Ca(2+) entry through the same site. Using brief pulses to 200 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5519c81f7f0a94bd71ef37a66e762d0
https://doi.org/10.1085/jgp.200709734
https://doi.org/10.1085/jgp.200709734
Autor:
Roman Shirokov
Publikováno v:
Science and Education of the Bauman MSTU. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8e94fac80f1deb7d837285b5c23c3de
https://doi.org/10.7463/1214.0724735
https://doi.org/10.7463/1214.0724735
Publikováno v:
The Journal of Physiology. 565:709-715
We examined changes in ionic and gating currents in CaV1.2 channels when extracellular Ca2+ was reduced from 10 mm to 0.1 μm. Saturating gating currents decreased by two-thirds (KD≈ 40 μm) and ionic currents increased 5-fold (KD≈ 0.5 μm) due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cbea459ee1d67bac9f54c6ae707dba1
https://doi.org/10.1113/jphysiol.2005.086561
https://doi.org/10.1113/jphysiol.2005.086561
Autor:
Roman Shirokov
Publikováno v:
The Journal of Physiology. 518:697-703
1Inactivation of neuronal N-type Ca2+ channels transiently expressed in human kidney tSA-201 cells was studied at the level of whole-cell Ca2+ current and intramembrane charge movement. 2Prolonged (5 s) depolarization to 40 mV shifted the voltage dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f898a483d3e4577e19f3dbcea35c70af
https://doi.org/10.1111/j.1469-7793.1999.0697p.x
https://doi.org/10.1111/j.1469-7793.1999.0697p.x
Autor:
Jianxun Yi, Edward Perez-Reyes, Jingsong Zhou, Leanne L. Cribbs, Eduardo Ríos, Roman Shirokov
Publikováno v:
Journal of Biological Chemistry. 273:25503-25509
In skeletal muscle the dihydropyridine receptor is the voltage sensor for excitation-contraction coupling and an L-type Ca2+ channel. We cloned a dihydropyridine receptor (named Fgalpha1S) from frog skeletal muscle, where excitation-contraction coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0533f7d497e95a035283788f0046e8df
https://doi.org/10.1074/jbc.273.39.25503
https://doi.org/10.1074/jbc.273.39.25503
Publikováno v:
Journal of General Physiology. 111:807-823
In studies of gating currents of rabbit cardiac Ca channels expressed as α 1C /β 2a or α 1C /β 2a /α 2 δ subunit combinations in tsA201 cells, we found that long-lasting depolarization shifted the distribution of mobile charge to very negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54971fc93a428a5de1144c1e0e6d1de0
https://doi.org/10.1085/jgp.111.6.807
https://doi.org/10.1085/jgp.111.6.807
Publikováno v:
The Journal of General Physiology
It is widely believed that Ba2+ currents carried through L-type Ca2+ channels inactivate by a voltage-dependent mechanism similar to that described for other voltage-dependent channels. Studying ionic and gating currents of rabbit cardiac Ca2+ channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a51c3b593a7085406c749ed18c91b8
http://europepmc.org/articles/PMC2219436
http://europepmc.org/articles/PMC2219436
Publikováno v:
Journal of Biological Chemistry. 271:26465-26468
The hydrophilic beta2a subunit of the L-type calcium channel was recently shown to be a membrane-localized, post-translationally modified protein (Chien, A. J., Zhao, X. L., Shirokov, R. E., Puri, T. S., Chang, C. F., Sun, D. D., Rios, E., and Hosey,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285bfc7323a2f0a0a2e86b5c390f846a
https://doi.org/10.1074/jbc.271.43.26465
https://doi.org/10.1074/jbc.271.43.26465