Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Roman Shimanovich"'
Autor:
Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael Ellis
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://doaj.org/article/c77d178e9fdf4a27bb6fc2263243c22d
Autor:
Lyuben Tsvetkov, Janét Pittsenbarger, Christian Atsriku, Paul Devine, Karen Dingley, Adam Levinson, Sayan Mondal, Joseph Piccotti, Roman Shimanovich, Lin Tang, Daniel Weiss, Jacky Woo, Min Ye, Wu Yin, Karen Akinsanya, Wayne Tang, Hamish Wright, Elie Traer, Kristian Jensen
Publikováno v:
Blood. 140:5961-5962
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e809af968f50e6befc43a0251620a5b
https://doi.org/10.1182/blood-2022-167239
https://doi.org/10.1182/blood-2022-167239
Autor:
John R, Butler, Gwenaella, Rescourio, Benjamin C, Milgram, Robert S, Foti, Thomas, Kornecook, Joseph, Ligutti, Bryan D, Moyer, Kristin, Taborn, Beth D, Youngblood, Violeta, Yu, Roman, Shimanovich, Alessandro, Boezio, Matthew, Weiss
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::026ead5bb43373a0b3209260097690d4
https://pubmed.ncbi.nlm.nih.gov/35850422
https://pubmed.ncbi.nlm.nih.gov/35850422
Autor:
Shivsmriti Koul, John Malona, Lisa Beebe, Laure Escoubet, Meghan Clements, Arvind Shakya, Veerabahu Shanmugasundaram, Lan Jiang, Lawrence G. Hamann, Matt M. Kreilein, Jenna Malley, C. Eric Schwartz, Roman Shimanovich, Ganesh Rajaraman, Alex Dubrovskiy, Laura Akullian D’Agostino, Justin Stedman, Andrea Local, J. Michael Ellis, Tiffany Carr, Steven A. Saenz, Haiqing Hu, John Cho, Lisa Chourb
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0248034 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0248034 (2021)
PLoS ONE
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fdb7715b2c933851e25206e28f0210
https://doi.org/10.1101/2021.02.19.431952
https://doi.org/10.1101/2021.02.19.431952
Autor:
Daniel G. Greene, Kaitlyn Wendl, Hyunsoo Park, Scott Sherman, Roman Shimanovich, Darren L. Reid, Prashant Agarwal, Leonela Vega
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 158
Sustained-release formulations are important tools to convert efficacious molecules into therapeutic products. Hydrogels enable the rapid assessment of sustained-release strategies, which are important during preclinical development where drug quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87e6649e55ffd81d909043e13380b32
https://pubmed.ncbi.nlm.nih.gov/33359482
https://pubmed.ncbi.nlm.nih.gov/33359482
Autor:
Wu Yin, Zhe Nie, Karen Dingley, Michael Trzoss, Goran Krilov, Netonia Marshall, Shulu Feng, Robert Pelletier, Jeff Bell, Paul Devine, Peter Skrdla, Roman Shimanovich, Min Ye, David Calkins, Mary Grimes, Wayne Tang, Andrew Placzek, Morgan Lawrenz, Fiona McRobb, Aleksey Gerasyuto, Victoria Feher, Sayan Mondal, Kristian Jensen, Hamish Wright, Daniel Weiss, Karen Akinsanya
Publikováno v:
Blood. 138:1187-1187
Introduction: MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a key mediator of the NF-κB signaling pathway, the main driver of a subset of B-cell lymphomas and functions by forming a complex with CARMA1 and BCL10 to me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f2170e0b6b0b1b555037cf159c1831
https://doi.org/10.1182/blood-2021-153159
https://doi.org/10.1182/blood-2021-153159
Autor:
Jessica Able, Benjamin C. Milgram, Loren Berry, Melanie Cooke, Liyue Huang, John Butler, Hongbing Huang, Violeta Yu, Kristin Taborn, John D. Roberts, Steven Altmann, Margaret Y. Chu-Moyer, John Yeoman, Jean Wang, Roman Shimanovich, Russell Graceffa, Matthew Weiss, Thomas Kornecook, Christopher P Ilch, Bryan D. Moyer, Christiane Boezio, Isaac E. Marx, Brian A. Sparling, Emily A. Peterson, Gwen Rescourio, Charles Kreiman, Elma Feric Bojic, Karina R. Vaida, Angel Guzman-Perez, Dawn Zhu, Hua Gao, Laurie B. Schenkel, Michael Jarosh, Hanh Nho Nguyen, Joseph Ligutti, Alessandro Boezio, Hakan Gunaydin, Daniel S. La, Thomas Dineen, Robert T. Fremeau, Robert S. Foti, Min-Hwa Jasmine Lin, Erin F. DiMauro, John Stellwagen
Publikováno v:
Journal of Medicinal Chemistry. 60:5990-6017
Because of its strong genetic validation, NaV1.7 has attracted significant interest as a target for the treatment of pain. We have previously reported on a number of structurally distinct bicyclic heteroarylsulfonamides as NaV1.7 inhibitors that demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6062704d531ce83c1a6122ecc44600
https://doi.org/10.1021/acs.jmedchem.6b01850
https://doi.org/10.1021/acs.jmedchem.6b01850
Autor:
Karen Rex, Douglas A. Whittington, David Bauer, Steven F. Bellon, Jean-Christophe Harmange, Martin A. Broome, Alessandro Boezio, Christiane Boezio, Karina R. Vaida, Deborah Choquette, Isabelle Dussault, Katrina W. Copeland, Emily A. Peterson, Yohannes Teffera, Roman Shimanovich, Brian K. Albrecht, Richard T. Lewis, Michele Potashman, Jingzhou Liu, Julia Lohman, Angela Coxon, Min-Hwa Jasmine Lin, Satoko Hirai
Publikováno v:
Journal of Medicinal Chemistry. 59:2328-2342
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report the discovery of compound 23 (AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16401f5e9358f2456fce2725cd044c7
https://doi.org/10.1021/acs.jmedchem.5b01716
https://doi.org/10.1021/acs.jmedchem.5b01716
Autor:
Karen Rex, Beth Hinkle, J. Russell Lipford, Brian A. Lanman, Victor J. Cee, Roman Shimanovich, Anne Y. Saiki, Laurie P. Volak
Publikováno v:
Molecular Cancer Research. 18:IA20-IA20
KRAS is one of the most frequently mutated oncogenes in human cancer, with KRASp.G12D, p.G12V, and p.G12C constituting the major mutational subtypes across lung, colon, and pancreatic cancers. Despite over three decades of research, indirect approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59a63db92375d1dc8c837d38b0417c46
https://doi.org/10.1158/1557-3125.ras18-ia20
https://doi.org/10.1158/1557-3125.ras18-ia20
Autor:
Russell F, Graceffa, Alessandro A, Boezio, Jessica, Able, Steven, Altmann, Loren M, Berry, Christiane, Boezio, John R, Butler, Margaret, Chu-Moyer, Melanie, Cooke, Erin F, DiMauro, Thomas A, Dineen, Elma, Feric Bojic, Robert S, Foti, Robert T, Fremeau, Angel, Guzman-Perez, Hua, Gao, Hakan, Gunaydin, Hongbing, Huang, Liyue, Huang, Christopher, Ilch, Michael, Jarosh, Thomas, Kornecook, Charles R, Kreiman, Daniel S, La, Joseph, Ligutti, Benjamin C, Milgram, Min-Hwa Jasmine, Lin, Isaac E, Marx, Hanh N, Nguyen, Emily A, Peterson, Gwen, Rescourio, John, Roberts, Laurie, Schenkel, Roman, Shimanovich, Brian A, Sparling, John, Stellwagen, Kristin, Taborn, Karina R, Vaida, Jean, Wang, John, Yeoman, Violeta, Yu, Dawn, Zhu, Bryan D, Moyer, Matthew M, Weiss
Publikováno v:
Journal of medicinal chemistry. 60(14)
Because of its strong genetic validation, Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8ea84d65ab7dd59414c7bfc36426140
https://pubmed.ncbi.nlm.nih.gov/28324649
https://pubmed.ncbi.nlm.nih.gov/28324649