Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Roman Rukwied"'
Publikováno v:
PAIN Reports, Vol 9, Iss 5, p e1190 (2024)
Abstract. Introduction:. Injection of recombinant human nerve growth factor (rhNGF) evokes acute heat and prolonged “polymodal” (mechanosensitive [CM]) and “silent” (mechanoinsensitive [CMi]) C-nociceptor sensitization. Both nociceptor classe
Externí odkaz:
https://doaj.org/article/2994ab5a8e3245a198dc715cf4a6701e
Publikováno v:
PLoS ONE, Vol 19, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/177a3430a7094343a74ff73a619cb077
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Single intradermal injections of nerve growth factor (NGF) evoke prolonged but temporally distinct sensitization patterns to somatosensory stimuli. Focal administration of the non-histaminergic pruritogen cowhage but not histamine resulted i
Externí odkaz:
https://doaj.org/article/8d4c5dba13f946068dab5b501ebb67c2
Autor:
Gunther Landmann, Lenka Stockinger, Benjamin Gerber, Justus Benrath, Martin Schmelz, Roman Rukwied
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271327 (2022)
We explored whether increased C-nociceptor excitability predicts analgesic effects of topical lidocaine in 33 patients with mono- (n = 15) or poly-neuropathy (n = 18). Excitability of C-nociceptors was tested by transcutaneous electrical sinusoidal (
Externí odkaz:
https://doaj.org/article/96e5321fab424a328a9541ddcc60e91f
Autor:
Hans Jürgen Solinski, Roman Rukwied
Publikováno v:
Frontiers in Medicine, Vol 7 (2021)
Administration of chemicals (pruritogens) into the skin evokes itch based on signal transduction mechanisms that generate action potentials mainly in mechanically sensitive and insensitive primary afferent C-fibers (pruriceptors). These signals from
Externí odkaz:
https://doaj.org/article/ed62f5eb44fa4e49823ec802af3a4280
Publikováno v:
Acta Dermato-Venereologica, Vol 100, Iss 17, p adv00302 (2020)
Slowly depolarizing currents applied for one minute have been shown to activate C-nociceptors and provoke increasing pain in patients with neuropathy. This study examined the effect of transcutaneous slowly depolarizing currents on pruritus in patien
Externí odkaz:
https://doaj.org/article/f3deead4daa64d578179a930b31d00f6
Autor:
Robin Jonas, Vincenzo Prato, Stefan G. Lechner, Gerbrand Groen, Otilia Obreja, Fiona Werland, Roman Rukwied, Andreas Klusch, Marlen Petersen, Richard W. Carr, Martin Schmelz
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Pronounced activity-dependent slowing of conduction has been used to characterize mechano-insensitive, “silent” nociceptors and might be due to high expression of NaV1.8 and could, therefore, be characterized by their tetrodotoxin-resistance (TTX
Externí odkaz:
https://doaj.org/article/940d087a68b74902b0e07b9c69eb24d5
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/a03bece062614ee9af8d89e889ab160e
Autor:
Benjamin Weinkauf, Roman Rukwied, Hans Quiding, Leif Dahllund, Patrick Johansson, Martin Schmelz
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39411 (2012)
UV-irradiation is a well-known translational pain model inducing local inflammation and primary hyperalgesia. The mediators and receptor proteins specifically contributing to mechanical or heat hyperalgesia are still unclear. Therefore, we irradiated
Externí odkaz:
https://doaj.org/article/03b860495d654114885c9df5e5374dd7
Autor:
Janet Weber, Marcus Schley, Matthias Casutt, Helmut Gerber, Guido Schuepfer, Roman Rukwied, Wolfgang Schleinzer, Michael Ueberall, Christoph Konrad
Publikováno v:
Anesthesiology Research and Practice, Vol 2009 (2009)
Central neuropathic pain is difficult to treat, but delta 9-Tetrahydrocannabinol (delta 9-THC) may be a promising therapeutic agent. We administered in 172 patients on average 7.5 mg delta 9-THC over 7 months. Of these, 48 patients prematurely withdr
Externí odkaz:
https://doaj.org/article/dff30598fa434e68a03cbfc93cff999b