Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Roman R. Schlimgen"'
Autor:
Roman R. Schlimgen, Francis C. Peterson, Raimond Heukers, Martine J. Smit, John D. McCorvy, Brian F. Volkman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract G protein-coupled receptors (GPCRs) are pivotal therapeutic targets, but their complex structure poses challenges for effective drug design. Nanobodies, or single-domain antibodies, have emerged as a promising therapeutic strategy to target
Externí odkaz:
https://doaj.org/article/52636f4e898c4c9caf197813d718a9df
Autor:
Angela L. Zhou, Davin R. Jensen, Francis C. Peterson, Monica A. Thomas, Roman R. Schlimgen, Michael B. Dwinell, Brian C. Smith, Brian F. Volkman
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 163-169 (2023)
The mucosal chemokine CCL28 is a promising target for immunotherapy drug development due to its elevated expression level in epithelial cells and critical role in creating and maintaining an immunosuppressive tumor microenvironment. Using sulfotyrosi
Externí odkaz:
https://doaj.org/article/cda8960ad51a44dcad7771ca3279a769
Autor:
Christian Berg, Michael J Wedemeyer, Motiejus Melynis, Roman R Schlimgen, Lasse H Hansen, Jon Våbenø, Francis C Peterson, Brian F Volkman, Mette M Rosenkilde, Hans R Lüttichau
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010355 (2022)
Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised patients. The UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 different CXC chemokines. One genotype (vCXCL1GT1) is a known agonist for CXCR1 and
Externí odkaz:
https://doaj.org/article/b58f3e9f294b4bb682ffd33432ab9a5c