Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Roman P. Jakob"'
Autor:
Gabriel Žoldák, Thomas A. Knappe, Anne-Juliane Geitner, Christian Scholz, Holger Dobbek, Franz X. Schmid, Roman P. Jakob
Publikováno v:
Molecules, Vol 29, Iss 7, p 1440 (2024)
Many folding enzymes use separate domains for the binding of substrate proteins and for the catalysis of slow folding reactions such as prolyl isomerization. FKBP12 is a small prolyl isomerase without a chaperone domain. Its folding activity is low,
Externí odkaz:
https://doaj.org/article/f5b9ea901fb44c5b9bdeacab0da090c8
Autor:
Ricardo D. Righetto, Leonie Anton, Ricardo Adaixo, Roman P. Jakob, Jasenko Zivanov, Mohamed-Ali Mahi, Philippe Ringler, Torsten Schwede, Timm Maier, Henning Stahlberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Urease is a nickel enzyme responsible for catalyzing the conversion of urea into ammonia and carbon dioxide. Here the authors report a high resolution cryo-EM structure of urease from the bacterial pathogen Yersinia enterocolitica, providing a detail
Externí odkaz:
https://doaj.org/article/3061b5e260314c16bdfa321e2acc5397
Autor:
Nils Böhringer, Robert Green, Yang Liu, Ute Mettal, Michael Marner, Seyed Majed Modaresi, Roman P. Jakob, Zerlina G. Wuisan, Timm Maier, Akira Iinishi, Sebastian Hiller, Kim Lewis, Till F. Schäberle
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT There is great need for therapeutics against multidrug-resistant, Gram-negative bacterial pathogens. Recently, darobactin A, a novel bicyclic heptapeptide that selectively kills Gram-negative bacteria by targeting the outer membrane protein
Externí odkaz:
https://doaj.org/article/1d9de47591604c918f32d1bde797defd
Autor:
M. Alessandra Vigano, Dimitri Bieli, Jonas V. Schaefer, Roman P. Jakob, Shinya Matsuda, Timm Maier, Andreas Plückthun, Markus Affolter
Publikováno v:
Biology Open, Vol 7, Iss 12 (2018)
Externí odkaz:
https://doaj.org/article/cab3c97b3cef4346a37698c7cda07bc9
Autor:
M. Alessandra Vigano, Dimitri Bieli, Jonas V. Schaefer, Roman P. Jakob, Shinya Matsuda, Timm Maier, Andreas Plückthun, Markus Affolter
Publikováno v:
Biology Open, Vol 7, Iss 11 (2018)
Over the last few years, protein-based affinity reagents have proven very helpful in cell and developmental biology. While many of these versatile small proteins can be expressed both in the intracellular and extracellular milieu in cultured cells an
Externí odkaz:
https://doaj.org/article/9d30b565975745cab629c52a96785972
Autor:
Ricardo D. Righetto, Leonie Anton, Ricardo Adaixo, Roman P. Jakob, Jasenko Zivanov, Mohamed-Ali Mahi, Philippe Ringler, Torsten Schwede, Timm Maier, Henning Stahlberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19845-z.
Externí odkaz:
https://doaj.org/article/13f5b90351d34326ba475879db20905b
Autor:
Maximilian M. Sauer, Roman P. Jakob, Jonathan Eras, Sefer Baday, Deniz Eriş, Giulio Navarra, Simon Bernèche, Beat Ernst, Timm Maier, Rudi Glockshuber
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Catch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli.Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction bet
Externí odkaz:
https://doaj.org/article/15996d3b67454979a441ce96b98b7d26
Autor:
Janine D Brunner, Roman P Jakob, Tobias Schulze, Yvonne Neldner, Anna Moroni, Gerhard Thiel, Timm Maier, Stephan Schenck
Publikováno v:
eLife, Vol 9 (2020)
The TMEM175 family constitutes recently discovered K+channels that are important for autophagosome turnover and lysosomal pH regulation and are associated with the early onset of Parkinson Disease. TMEM175 channels lack a P-loop selectivity filter, a
Externí odkaz:
https://doaj.org/article/f8445f40a87949708e12e0e16e894c2a
Autor:
Polina Isaikina, Ivana Petrovic, Roman P. Jakob, Parishmita Sarma, Ashutosh Ranjan, Minakshi Baruah, Vineet Panwalkar, Timm Maier, Arun K. Shukla, Stephan Grzesiek
SummaryThe two non-visual arrestin isoforms, arrestin2 and arrestin3 recognize and bind hundreds of G protein-coupled receptors (GPCRs) with different phosphorylation patterns leading to distinct functional outcomes. The impact of phosphorylation on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ef341d37d8c1b89ec1eb120b3e89bd
https://doi.org/10.1101/2022.10.10.511578
https://doi.org/10.1101/2022.10.10.511578
Autor:
Yves U, Tittes, Dominik A, Herbst, Solène F X, Martin, Hugo, Munoz-Hernandez, Roman P, Jakob, Timm, Maier
Publikováno v:
Science advances. 8(38)
Polyketide synthases (PKSs) are predominantly microbial biosynthetic enzymes. They assemble highly potent bioactive natural products from simple carboxylic acid precursors. The most versatile families of PKSs are organized as assembly lines of functi