Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Roman M, Doll"'
Autor:
Kathleen A. Christie, Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman, Jiecong Lin, Linyuan Ma, Russell T. Walton, Luca Pinello, G. Brett Robb, Benjamin P. Kleinstiver
Publikováno v:
Nature Biotechnology. 41:409-416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d76210e861acf8181c3af196e0bc046a
https://doi.org/10.1038/s41587-022-01492-y
https://doi.org/10.1038/s41587-022-01492-y
Autor:
Christiano R. R. Alves, Leillani L. Ha, Rebecca Yaworski, Cicera R. Lazzarotto, Kathleen A. Christie, Aoife Reilly, Ariane Beauvais, Roman M. Doll, Demitri de la Cruz, Casey A. Maguire, Kathryn J. Swoboda, Shengdar Q. Tsai, Rashmi Kothary, Benjamin P. Kleinstiver
Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by mutations in theSMN1gene. Despite the development of various therapies, outcomes can remain suboptimal in SMA infants and the duration of such therapies are uncertain.SMN2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eaa7a91ed126da64d6658d42d9a9fde
https://doi.org/10.1101/2023.01.20.524978
https://doi.org/10.1101/2023.01.20.524978
Autor:
Kathleen A. Christie, Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman, Linyuan Ma, G. Brett Robb, Benjamin P. Kleinstiver
While restriction enzymes (REs) remain the gold-standard for manipulating DNA in vitro, they have notable drawbacks including a dependence on short binding motifs that constrain their ability to cleave DNA substrates. Here we overcome limitations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90883b1070d6818cc6bf7499320c9c40
https://doi.org/10.1101/2022.01.11.474553
https://doi.org/10.1101/2022.01.11.474553
Autor:
Kathleen A, Christie, Jimmy A, Guo, Rachel A, Silverstein, Roman M, Doll, Megumu, Mabuchi, Hannah E, Stutzman, Jiecong, Lin, Linyuan, Ma, Russell T, Walton, Luca, Pinello, G Brett, Robb, Benjamin P, Kleinstiver
Publikováno v:
Nature biotechnology.
Methods for in vitro DNA cleavage and molecular cloning remain unable to precisely cleave DNA directly adjacent to bases of interest. Restriction enzymes (REs) must bind specific motifs, whereas wild-type CRISPR-Cas9 or CRISPR-Cas12 nucleases require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bd132efe9eb805fbd83df8e578a7a56
https://pubmed.ncbi.nlm.nih.gov/36203014
https://pubmed.ncbi.nlm.nih.gov/36203014