Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Roman Lesyk"'
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 9, Pp 100951- (2024)
In various industries, particularly in the chemical and pharmaceutical fields, Fourier transform infrared spectroscopy (FTIR) spectroscopy provides a unique capacity to detect and characterise complex chemicals while minimising environmental damage b
Externí odkaz:
https://doaj.org/article/302af615c31c48cbbd47f1756e735c41
Autor:
Piotr Roszczenko, Olga Klaudia Szewczyk-Roszczenko, Agnieszka Gornowicz, Robert Czarnomysy, Andrii Lozynskyi, Krzysztof Bielawski, Roman Lesyk, Anna Bielawska
Publikováno v:
Molecules, Vol 29, Iss 21, p 5117 (2024)
Gastric cancer remains a significant therapeutic challenge, highlighting the need for new strategies to improve treatment efficacy. This study investigates the potential of combined therapy with the novel Thiopyrano[2,3-d]Thiazole derivative LES-6400
Externí odkaz:
https://doaj.org/article/63e32af91ecf4a15b62cbf2959f0edb0
Publikováno v:
Molbank, Vol 2024, Iss 1, p M1785 (2024)
In this work, the title compound was synthesized via the Claisen–Schmidt condensation of a 2-((5-acetyl-4-methylthiazol-2-yl)amino)isoindoline-1,3-dione with 2-fluorobenzaldehyde. The structure of the synthesized compound (yield 62%) was confirmed
Externí odkaz:
https://doaj.org/article/104a8348a493455184add2b53baa7b5b
Autor:
Edyta Kaleniuk, Serhii Holota, Bartosz Skóra, Dmytro Khylyuk, Anna Tabęcka-Łonczyńska, Roman Lesyk, Konrad A. Szychowski
Publikováno v:
Applied Sciences, Vol 14, Iss 17, p 7692 (2024)
Presently, a major challenge is the search for new compounds that may exhibit an inhibitory effect on tumor progression. Recently, the 4-thiazolidinone (4-TZD) group has gained attention in this research field. The aim of the present study was to eva
Externí odkaz:
https://doaj.org/article/6df93435b7b948128ec84dbc5f1cd4db
Role of 4-Thiazolidinone–Pyrazoline/Indoline Hybrids Les-4369 and Les-3467 in BJ and A549 Cell Lines
Autor:
Karolina Kosińska, Bartosz Skóra, Serhii Holota, Yulia Shepeta, Anna Tabęcka-Łonczyńska, Roman Lesyk, Konrad A. Szychowski
Publikováno v:
Cells, Vol 13, Iss 12, p 1007 (2024)
Cancer is one of the most important problems of modern societies. Recently, studies have reported the anticancer properties of rosiglitazone related to its ability to bind peroxisome proliferator receptor γ (PPARγ), which has various effects on can
Externí odkaz:
https://doaj.org/article/2888d91256ec4667861eaaf5050a1ada
Autor:
Natalia Tkachenko, Ostap Pankevych, Tamara Mahanova, Bohdan Hromovyk, Roman Lesyk, Lilia Lesyk
Publikováno v:
Pharmacy, Vol 12, Iss 2, p 64 (2024)
Healthcare plays a crucial role in public and national safety as a significant part of state activity and a component of national safety, whose mission is to organize and ensure affordable medical care for the population. The four stages of the genes
Externí odkaz:
https://doaj.org/article/de21ac53633d4ce8994bf2331b78f4cf
Autor:
Yulian Konechnyi, Tetyana Rumynska, Ihor Yushyn, Serhii Holota, Vira Turkina, Mariana Ryviuk Rydel, Alicja Sękowska, Yuriy Salyha, Olena Korniychuk, Roman Lesyk
Publikováno v:
Antibiotics, Vol 13, Iss 4, p 291 (2024)
A novel 4-thiazolidinone derivative Les-6490 (pyrazol-4-thiazolidinone hybrid) was designed, synthesized, and characterized by spectral data. The compound was screened for its antimicrobial activity against some pathogenic bacteria and fungi and show
Externí odkaz:
https://doaj.org/article/1fe990877e5043d8bb151b679fcdd08c
Publikováno v:
Molecules, Vol 29, Iss 2, p 346 (2024)
Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are hormones that contribute to the growth of certain types of breast cancer. In particular, aromatase catalyzes the conversion of androgens (male hormones) into
Externí odkaz:
https://doaj.org/article/7723771bfe3a416da326cb5751e78555
Autor:
Olga Klaudia Szewczyk-Roszczenko, Piotr Roszczenko, Anna Shmakova, Nataliya Finiuk, Serhii Holota, Roman Lesyk, Anna Bielawska, Yegor Vassetzky, Krzysztof Bielawski
Publikováno v:
Cells, Vol 12, Iss 18, p 2312 (2023)
Endocytosis is one of the major ways cells communicate with their environment. This process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic transformation. Here, we review the approaches to inhibit endocytosis, dis
Externí odkaz:
https://doaj.org/article/240d6a12375b49b7b04c384bef8ac300
Autor:
Ivan Sydorenko, Serhii Holota, Andrii Lozynskyi, Yulian Konechnyi, Volodymyr Horishny, Andriy Karkhut, Svyatoslav Polovkovych, Olexandr Karpenko, Roman Lesyk
Publikováno v:
Molbank, Vol 2022, Iss 4, p M1478 (2022)
Multicomponent reactions effectively contribute to modern organic and medicinal chemistry. 4-Thiazolidinone core and cyclopropyl moiety are important structural motifs for design of potential biologically active molecules. In the present paper, the c
Externí odkaz:
https://doaj.org/article/e246e79f58384ceaaed63f9edf48155f