Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Roman Lagoutte"'
Autor:
Roman Lagoutte, Christelle Serba, Daniel Abegg, Dominic G. Hoch, Alexander Adibekian, Nicolas Winssinger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Deoxyelephantopin is a naturally occurring sesquiterpene lactone with known anticancer properties. Here, the authors synthesize deoxyelephantopins and a range of analogues including alkyne-tagged probes, using them to identify its cellular targets.
Externí odkaz:
https://doaj.org/article/1ed6d7b632384db6874986b87650499b
Autor:
Roman Lagoutte, Nicolas Winssinger
Publikováno v:
CHIMIA, Vol 71, Iss 10 (2017)
Covalent inhibitors are re-emerging as pharmacologically interesting entities with several candidates having received recent approval for therapeutic intervention. Nature has embraced this strategy and many natural products possess mildly electrophil
Externí odkaz:
https://doaj.org/article/e3ee1c007dd14bac865dc381b2c214f9
Publikováno v:
Comprehensive Heterocyclic Chemistry IV ISBN: 9780128186565
Comprehensive Heterocyclic Chemistry IV
Comprehensive Heterocyclic Chemistry IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e9cc9edc64eeed8363f5539d9a87a03
https://doi.org/10.1016/b978-0-12-818655-8.00161-x
https://doi.org/10.1016/b978-0-12-818655-8.00161-x
Publikováno v:
European Journal of Organic Chemistry. 2016:4372-4381
The direct vinylogous Michael addition of unactivated α-Angelica lactone to enones under iminium activation using 9-amino-9-deoxy-epi-quinine as catalyst along with 2-hydroxy-1-naphthoic acid as co-catalyst has led to the formation of γ,γ-disubsti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef827cc83c8d35356a2d52d2013de40
https://doi.org/10.1002/ejoc.201600707
https://doi.org/10.1002/ejoc.201600707
Publikováno v:
Tetrahedron, Vol. 74, No 41 (2018) pp. 6012-6021
The sesquiterpene lactones cover a diverse and pharmacologically important diversity space. In particular, the electrophilic α-exo-methylene-γ-butyrolactone moiety that is preponderant in this natural product family has been shown to readily engage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf03edb455815bd43ee571a2182ec19
https://archive-ouverte.unige.ch/unige:107781
https://archive-ouverte.unige.ch/unige:107781
Publikováno v:
European Journal of Organic Chemistry
European Journal of Organic Chemistry, Vol. 2016, No 4 (2016) pp. 644-646
European Journal of Organic Chemistry, Vol. 2016, No 4 (2016) pp. 644-646
Sesquiterpenes have been a rich source of bioactive compounds and have inspired innovative methodological developments. Herein we report a rapid and scalable synthesis of a substrate for a 4+3 cycloaddition in order to access the cis-fused bicyclic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e7a82d675d3829a74d30e52afb51b9
https://doi.org/10.1002/ejoc.201501277
https://doi.org/10.1002/ejoc.201501277
Autor:
Nicolas Winssinger, Roman Lagoutte
Publikováno v:
Chimia, Vol. 71, No 10 (2017) pp. 703-711
CHIMIA, Vol 71, Iss 10 (2017)
CHIMIA, Vol 71, Iss 10 (2017)
Covalent inhibitors are re-emerging as pharmacologically interesting entities with several candidates having received recent approval for therapeutic intervention. Nature has embraced this strategy and many natural products possess mildly electrophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adb779d49de55ab4a9c81882a8e4375
https://pubmed.ncbi.nlm.nih.gov/29070414
https://pubmed.ncbi.nlm.nih.gov/29070414
Publikováno v:
Journal of Antibiotics, Vol. 71, No 2 (2018) pp. 248-256
Deoxyelephantopin is a sesquiterpene lactone that was reported to be as effective in the treatment of mammary tumours and lung metastasis as taxol based on a murine orthotopic cancer model. Its germacrene skeleton harbours three Michael acceptors tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346103948d1718d50520b5b7dd4a1df2
https://pubmed.ncbi.nlm.nih.gov/29089602
https://pubmed.ncbi.nlm.nih.gov/29089602
Publikováno v:
Current Opinion in Chemical Biology, Vol. 39 (2017) pp. 54-63
There is a resurging interest in compounds that engage their target through covalent interactions. Cysteine’s thiol is endowed with enhanced reactivity, making it the nucleophile of choice for covalent engagement with a ligand aligning an electroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f8b3be407f89c15ed2c6b0279ccfec
https://pubmed.ncbi.nlm.nih.gov/28609675
https://pubmed.ncbi.nlm.nih.gov/28609675
Publikováno v:
ChemInform. 47
Sesquiterpenes have been a rich source of bioactive compounds and have inspired innovative methodological developments. Herein we report a rapid and scalable synthesis of a substrate for a 4+3 cycloaddition in order to access the cis-fused bicyclic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9b3a8bd91e303c1385bf7bc79f927b5
https://doi.org/10.1002/chin.201614201
https://doi.org/10.1002/chin.201614201