Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

Autor: Adriana Hernandez-Morales, Lu Jiang, Trevor D. Lawley, Yi Duan, Peter Stärkel, Huikuan Chu, David T. Pride, Imran R Rahman, Philippe Mathurin, Bei Gao, Katharina Brandl, Francisco Bosques-Padilla, Yan Shao, Michael R. Lucey, Felix Hutmacher, Alexandre Louvet, Manolito Torralba, Ramon Bataller, Debbie L. Shawcross, Robert S. Brown, Suhan Lee, Derrick E. Fouts, Wilfred A. van der Donk, Jinyuan Liu, Weizhong Sun, Sonja Lang, Melissa Ly, Samuel B. Ho, Roman Kiesel, Kevin Nguyen, Juan G. Abraldes, Richard C. White, Guadalupe Garcia-Tsao, Yukiko Miyamoto, Xin M. Tu, Thomas H. Clarke, Lauren Lessor, José Altamirano, Elizabeth C. Verna, Ry Young, Juan Caballería, Meritxell Ventura-Cots, Victor Vargas, Cristina Llorente, Bernd Schnabl, Lars Eckmann

Publikováno v: Duan, Y, Llorente, C, Lang, S, Brandl, K, Chu, H, Jiang, L, White, R C, Clarke, T H, Nguyen, K, Torralba, M, Shao, Y, Liu, J, Hernandez-Morales, A, Lessor, L, Rahman, I R, Miyamoto, Y, Ly, M, Gao, B, Sun, W, Kiesel, R, Hutmacher, F, Lee, S, Ventura-Cots, M, Bosques-Padilla, F, Verna, E C, Abraldes, J G, Brown, R S, Vargas, V, Altamirano, J, Caballería, J, Shawcross, D L, Ho, S B, Louvet, A, Lucey, M R, Mathurin, P, Garcia-Tsao, G, Bataller, R, Tu, X M, Eckmann, L, van der Donk, W A, Young, R, Lawley, T D, Stärkel, P, Pride, D, Fouts, D E & Schnabl, B 2019, ' Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease ', Nature, vol. 575, no. 7783, pp. 505-511 . https://doi.org/10.1038/s41586-019-1742-x
Nature, Vol. 575, no. 7783, p. 505-511 (2019)
Nature, vol 575, iss 7783

Chronic liver disease due to alcohol-use disorder contributes markedly to the global burden of disease and mortality1–3. Alcoholic hepatitis is a severe and life-threatening form of alcohol-associated liver disease. The gut microbiota promotes etha

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https://kclpure.kcl.ac.uk/en/publications/e22cc724-059c-4840-baec-69a76ff63c0d