Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Roman K Thomas"'
Autor:
Silvia Querings, Janine Altmüller, Sascha Ansén, Thomas Zander, Danila Seidel, Franziska Gabler, Martin Peifer, Eva Markert, Kathryn Stemshorn, Bernd Timmermann, Beate Saal, Stefan Klose, Karen Ernestus, Matthias Scheffler, Walburga Engel-Riedel, Erich Stoelben, Elisabeth Brambilla, Jürgen Wolf, Peter Nürnberg, Roman K Thomas
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19601 (2011)
Treatment of EGFR-mutant non-small cell lung cancer patients with the tyrosine kinase inhibitors erlotinib or gefitinib results in high response rates and prolonged progression-free survival. Despite the development of sensitive mutation detection ap
Externí odkaz:
https://doaj.org/article/2d31e04b0ffd46d390a8ab983a70a0bf
Autor:
Martin Peifer, Jonathan Weiss, Martin L Sos, Mirjam Koker, Stefanie Heynck, Christian Netzer, Stefanie Fischer, Haridas Rode, Daniel Rauh, Jörg Rahnenführer, Roman K Thomas
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8919 (2010)
Despite the successful introduction of potent anti-cancer therapeutics, most of these drugs lead to only modest tumor-shrinkage or transient responses, followed by re-growth of tumors. Combining different compounds has resulted in enhanced tumor cont
Externí odkaz:
https://doaj.org/article/d43d914520a846449df82e6532342907
Autor:
Yixuan Gong, Evelyn Yao, Ronglai Shen, Aviva Goel, Maria Arcila, Julie Teruya-Feldstein, Maureen F Zakowski, Stanley Frankel, Martin Peifer, Roman K Thomas, Marc Ladanyi, William Pao
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7273 (2009)
The IGF receptor type 1 (IGF-1R) pathway is frequently deregulated in human tumors and has become a target of interest for anti-cancer therapy.We used a panel of 22 non-small cell lung cancer (NSCLC) cell lines to investigate predictive biomarkers of
Externí odkaz:
https://doaj.org/article/bed909bd7bda4d0eb0dbbacb1865f675
Autor:
Roland T Ullrich, Thomas Zander, Bernd Neumaier, Mirjam Koker, Takeshi Shimamura, Yannic Waerzeggers, Christa L Borgman, Samir Tawadros, Hongfeng Li, Martin L Sos, Heiko Backes, Geoffrey I Shapiro, Jürgen Wolf, Andreas H Jacobs, Roman K Thomas, Alexandra Winkeler
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3908 (2008)
BACKGROUND: Inhibition of the epidermal growth factor receptor (EGFR) has shown clinical success in patients with advanced non-small cell lung cancer (NSCLC). Somatic mutations of EGFR were found in lung adenocarcinoma that lead to exquisite dependen
Externí odkaz:
https://doaj.org/article/8f3796ed7f8842debdaa3df812da553c
Autor:
Jeffrey C Lee, Igor Vivanco, Rameen Beroukhim, Julie H Y Huang, Whei L Feng, Ralph M DeBiasi, Koji Yoshimoto, Jennifer C King, Phioanh Nghiemphu, Yuki Yuza, Qing Xu, Heidi Greulich, Roman K Thomas, J Guillermo Paez, Timothy C Peck, David J Linhart, Karen A Glatt, Gad Getz, Robert Onofrio, Liuda Ziaugra, Ross L Levine, Stacey Gabriel, Tomohiro Kawaguchi, Keith O'Neill, Haumith Khan, Linda M Liau, Stanley F Nelson, P Nagesh Rao, Paul Mischel, Russell O Pieper, Tim Cloughesy, Daniel J Leahy, William R Sellers, Charles L Sawyers, Matthew Meyerson, Ingo K Mellinghoff
Publikováno v:
PLoS Medicine, Vol 3, Iss 12, p e485 (2006)
Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory constraints on kinase activity, can promote malignant transformati
Externí odkaz:
https://doaj.org/article/5d6f59e01ba64895bd93a59b40622c4e
Autor:
Florian Malchers, Lucia Nogova, Martijn H.A. van Attekum, Lukas Maas, Johannes Brägelmann, Christoph Bartenhagen, Luc Girard, Graziella Bosco, Ilona Dahmen, Sebastian Michels, Clare E. Weeden, Andreas H. Scheel, Lydia Meder, Kristina Golfmann, Philipp Schuldt, Janna Siemanowski, Jan Rehker, Sabine Merkelbach-Bruse, Roopika Menon, Oliver Gautschi, Johannes M. Heuckmann, Elisabeth Brambilla, Marie-Liesse Asselin-Labat, Thorsten Persigehl, John D. Minna, Henning Walczak, Roland T. Ullrich, Matthias Fischer, Hans Christian Reinhardt, Jürgen Wolf, Reinhard Büttner, Martin Peifer, Julie George, Roman K. Thomas
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11% of patients with 8p11 amplification (detecte
Externí odkaz:
https://doaj.org/article/ef6247e9f6b84dbca5a0844486ed3d80
Autor:
Yosuke Yamada, Djeda Belharazem-Vitacolonnna, Hanibal Bohnenberger, Christel Weiß, Naoko Matsui, Mark Kriegsmann, Katharina Kriegsmann, Peter Sinn, Katja Simon-Keller, Gerhard Hamilton, Thomas Graeter, Gerhard Preissler, German Ott, Sebastian Schölch, Naoki Nakajima, Akihiko Yoshizawa, Hironori Haga, Hiroshi Date, Roman K. Thomas, Iacopo Petrini, Giuseppe Giaccone, Philipp Ströbel, Alexander Marx
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-11 (2022)
Abstract Tuft cells are chemosensory epithelial cells in the respiratory tract and several other organs. Recent studies revealed tuft cell-like gene expression signatures in some pulmonary adenocarcinomas, squamous cell carcinomas (SQCC), small cell
Externí odkaz:
https://doaj.org/article/aaade6c0d522458ea3d812565b5a42cc
Autor:
Simon Lennartz, Alina Mager, Nils Große Hokamp, Sebastian Schäfer, David Zopfs, David Maintz, Hans Christian Reinhardt, Roman K. Thomas, Liliana Caldeira, Thorsten Persigehl
Publikováno v:
Cancer Imaging, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background The purpose of this study was to analyze if the use of texture analysis on spectral detector CT (SDCT)-derived iodine maps (IM) in addition to conventional images (CI) improves lung nodule differentiation, when being applied to a
Externí odkaz:
https://doaj.org/article/1f46b64f9dd7422297b9bc2657acaeff
Autor:
Yabin Chen, Zhaoyuan Fang, Ying Tang, Yujuan Jin, Chenchen Guo, Liang Hu, Yang Xu, Xidong Ma, Jie Gao, Mei Xie, Xuelei Zang, Sanhong Liu, Haiquan Chen, Roman K. Thomas, Xinying Xue, Hongbin Ji, Luonan Chen
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 12, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/07e78d2f8427412bbc73872b3fd5aa3f
Autor:
Gero Knittel, Hans Christian Reinhardt, Ari M. Melnick, Ron D. Jachimowicz, Bastian von Tresckow, F. Thomas Wunderlich, Branko Zevnik, Bjoern Chapuy, Joachim R. Göthert, Sebastian Klein, Markus Chmielewski, Dinis Pedro Calado, Michael Hallek, Thorsten Persigehl, Monika Ortmann, Jörn Meinel, Philipp Lohneis, Reinhard Büttner, Alessandra Holzem, Filippo Beleggia, Lorenz Jonigkeit, Jacqueline Knüfer, Moritz Kochanek, Roman K. Thomas, Graziella Bosco, Nima Abedpour, Martin Peifer, Phuong-Hien Nguyen, Viktoria Kohlhas, Tobias Riet, Ilmars Kisis, Tim Lohmann, Pascal Nieper, Benedikt W. Pelzer, Julia Hansen, Ruth Flümann
Table S1 contains the p values of comparisons of the V gene usage in non-malignant GC B cells between the individual genotypes. These comparisons were done on the family, gene and allele level. V usage was compared for all BCR sequences as well as fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16522456824017cbee9d61e5a078d618
https://doi.org/10.1158/2643-3230.22546170.v1
https://doi.org/10.1158/2643-3230.22546170.v1
