Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Roman Körner"'
Autor:
Itika Saha, Patricia Yuste-Checa, Miguel Da Silva Padilha, Qiang Guo, Roman Körner, Hauke Holthusen, Victoria A. Trinkaus, Irina Dudanova, Rubén Fernández-Busnadiego, Wolfgang Baumeister, David W. Sanders, Saurabh Gautam, Marc I. Diamond, F. Ulrich Hartl, Mark S. Hipp
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Tau aggregates are associated with several neurodegenerative disorders. In this work, I. Saha and colleagues show that valosin-containing protein (VCP) recruited to Tau fibrils disaggregates them. However, this process comes at a cost: it generates s
Externí odkaz:
https://doaj.org/article/55b4a135031e4d249c4f455de3857bf8
Autor:
Liang Zhao, Giulia Vecchi, Michele Vendruscolo, Roman Körner, Manajit Hayer-Hartl, F. Ulrich Hartl
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1335-1345.e6 (2019)
Summary: Stress-inducible molecular chaperones have essential roles in maintaining protein homeostasis, but the extent to which they affect overall proteome stability remains unclear. Here, we analyze the effects of the DnaK (Hsp70) system on protein
Externí odkaz:
https://doaj.org/article/5f1789a4b41e4b01b9c1bcb3a2b6d66b
Autor:
Isabelle Chartrain, Yann Le Page, Guillaume Hatte, Roman Körner, Jacek Z. Kubiak, Jean-Pierre Tassan
Publikováno v:
Biology Open, Vol 2, Iss 10, Pp 1037-1048 (2013)
Summary Maternal Embryonic Leucine zipper Kinase (MELK) was recently shown to be involved in cell division of Xenopus embryo epithelial cells. The cytokinetic furrow of these cells ingresses asymmetrically and is developmentally regulated. Two subpop
Externí odkaz:
https://doaj.org/article/81015de49864433bbca168fab24a465f
Autor:
Ana M Rojas, Anna Santamaria, Rainer Malik, Thomas Skøt Jensen, Roman Körner, Ian Morilla, David de Juan, Martin Krallinger, Daniel Aaen Hansen, Robert Hoffmann, Jonathan Lees, Adam Reid, Corin Yeats, Anja Wehner, Sabine Elowe, Andrew B Clegg, Søren Brunak, Erich A Nigg, Christine Orengo, Alfonso Valencia, Juan A G Ranea
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e31813 (2012)
The mitotic spindle is an essential molecular machine involved in cell division, whose composition has been studied extensively by detailed cellular biology, high-throughput proteomics, and RNA interference experiments. However, because of its dynami
Externí odkaz:
https://doaj.org/article/70153f80d41f49f28dad5fc2de9963d1
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18793 (2011)
BACKGROUND: Members of the Mps1 kinase family play an essential and evolutionarily conserved role in the spindle assembly checkpoint (SAC), a surveillance mechanism that ensures accurate chromosome segregation during mitosis. Human Mps1 (hMps1) is hi
Externí odkaz:
https://doaj.org/article/0e362e332b5e4d3bb45fcdb19fe47f9b
Autor:
Itika Saha, Patricia Yuste-Checa, Miguel Da Silva Padilha, Qiang Guo, Roman Körner, Hauke Holthusen, Victoria A. Trinkaus, Irina Dudanova, Rubén Fernández-Busnadiego, Wolfgang Baumeister, David W. Sanders, Saurabh Gautam, Marc I. Diamond, F. Ulrich Hartl, Mark S. Hipp
Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The existence of cellular machinery for the removal of such aggregates has remained unclear, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::377a11ac3ba13792fcb8ab108b3e97aa
https://doi.org/10.1101/2022.02.18.481043
https://doi.org/10.1101/2022.02.18.481043
Autor:
Yuma Kawaguchi, Roman Körner, Hironaga Uchida, Jörg Schulze, Inga A. Fischer, Lion Augel, Stefan Bechler
Publikováno v:
ACS Photonics. 5:4586-4593
Refractive index sensing is a highly sensitive and label-free detection method for molecular binding events. Commercial implementations of biosensing concepts based on plasmon resonances typically require significant external instrumentation such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac03716e4c4d8f9fb89e093c3efc939b
https://doi.org/10.1021/acsphotonics.8b01067
https://doi.org/10.1021/acsphotonics.8b01067
Autor:
Anne Sigaard Bie, Johan Palmfeldt, Cagla Cömert, Mark S. Hipp, Roman Körner, Thomas J. Corydon, Peter Bross, F. Ulrich Hartl
Publikováno v:
Cell Stress Chaperones
Bie, A S, Cömert, C, Körner, R, Corydon, T J, Palmfeldt, J, Hipp, M S, Hartl, F U & Bross, P 2020, ' An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space ', Cell Stress & Chaperones, vol. 25, no. 3, pp. 407-416 . https://doi.org/10.1007/s12192-020-01080-6
Cell stress & chaperones, 25(3), 407-416. SPRINGER
Bie, A S, Cömert, C, Körner, R, Corydon, T J, Palmfeldt, J, Hipp, M S, Hartl, F U & Bross, P 2020, ' An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space ', Cell Stress & Chaperones, vol. 25, no. 3, pp. 407-416 . https://doi.org/10.1007/s12192-020-01080-6
Cell stress & chaperones, 25(3), 407-416. SPRINGER
The HSP60/HSP10 chaperonin assists folding of proteins in the mitochondrial matrix space by enclosing them in its central cavity. The chaperonin forms part of the mitochondrial protein quality control system. It is essential for cellular survival and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea0cb58e78d8681653ca20b23bf8d06
https://pubmed.ncbi.nlm.nih.gov/32060690
https://pubmed.ncbi.nlm.nih.gov/32060690
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2030
Amino acid analysis is among the most accurate methods for absolute quantification of proteins and peptides. Here, we combine acid hydrolysis with the addition of isotopically labeled standard amino acids and analysis by mass spectrometry for accurat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b0f1af76b56d53de5f8995650080c92
https://pubmed.ncbi.nlm.nih.gov/31347106
https://pubmed.ncbi.nlm.nih.gov/31347106
Autor:
Frédéric Frottin, Ralf Jungmann, Rajat Gupta, Mark S. Hipp, Thomas Schlichthaerle, Florian Schueder, Franz-Ulrich Hartl, Shivani Tiwary, Roman Körner, Jürgen Cox
Publikováno v:
Science
Phasing-in quality control in the nucleus The fundamental process of protein quality control in the nucleus is not well understood. The nucleus contains several non–membrane-bound subcompartments forming liquid-like condensates. The largest of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6955da9a8444e394763cfc57d6063f46
https://hdl.handle.net/21.11116/0000-0004-5861-C21.11116/0000-0004-5863-A
https://hdl.handle.net/21.11116/0000-0004-5861-C21.11116/0000-0004-5863-A