Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Roman J, Szczesny"'
Autor:
Anna Hojka-Osinska, Aleksander Chlebowski, Joanna Grochowska, Ewelina P. Owczarek, Kamila Affek, Kamila Kłosowska-Kosicka, Roman J. Szczesny, Andrzej Dziembowski
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103036- (2021)
Summary: Processive exoribonucleases are executors of RNA decay. In humans, their physical but not functional interactions were thoughtfully investigated. Here we have screened cells deficient in DIS3, XRN2, EXOSC10, DIS3L, and DIS3L2 with a custom s
Externí odkaz:
https://doaj.org/article/7875acc6df5e460a9160e947aed36e09
Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
Autor:
Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski, Roman J. Szczesny
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to t
Externí odkaz:
https://doaj.org/article/ecae75cc636546cf9e7e85d311c81677
Autor:
Katarzyna Rawa, Roman J. Szczesny, Ewelina P. Owczarek, Anna Adamowicz-Salach, Anna Klukowska, Urszula Demkow, Danuta Plochocka, Pawel Szczesny, Monika Gora, Andrzej Dziembowski, Beata Burzynska
Publikováno v:
BMC Medical Genetics, Vol 18, Iss 1, Pp 1-6 (2017)
Abstract Background The thalassemia syndromes are classified according to the globin chain or chains whose production is affected. β-thalassemias are caused by point mutations or, more rarely, deletions or insertions of a few nucleotides in the β-g
Externí odkaz:
https://doaj.org/article/fc2fa0a2aaf14b5aa45fdaf66d2a68f1
Autor:
Anna Karlowicz, Andrzej B Dubiel, Jolanta Czerwinska, Adela Bledea, Piotr Purzycki, Marta Grzelewska, Ryan J McAuley, Roman J Szczesny, Gabriela Brzuska, Ewelina Krol, Bartosz Szczesny, Michal R Szymanski
Publikováno v:
Nucleic Acids Research. 50:7991-8007
The removal of RNA primers is essential for mitochondrial DNA (mtDNA) replication. Several nucleases have been implicated in RNA primer removal in human mitochondria, however, no conclusive mechanism has been elucidated. Here, we reconstituted minima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008369f26c85e94a94171e3716fdd8c3
https://doi.org/10.1093/nar/gkac581
https://doi.org/10.1093/nar/gkac581
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::261696e0f0126193a9667b6b7103f189
https://doi.org/10.3791/65236
https://doi.org/10.3791/65236
Autor:
Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski, Roman J. Szczesny
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 6 (2018)
Transcription of the human mitochondrial genome produces a vast amount of non-coding antisense RNAs. These RNA species can form G-quadraplexes (G4), which affect their decay. We found that the mitochondrial degradosome, a complex of RNA helicase SUPV
Externí odkaz:
https://doaj.org/article/68a4455d506c46f09067bb904eb47092
Autor:
Roman J Szczesny, Katarzyna Kowalska, Kamila Klosowska-Kosicka, Aleksander Chlebowski, Ewelina P Owczarek, Zbigniew Warkocki, Tomasz M Kulinski, Dorota Adamska, Kamila Affek, Agata Jedroszkowiak, Anna V Kotrys, Rafal Tomecki, Pawel S Krawczyk, Lukasz S Borowski, Andrzej Dziembowski
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194887 (2018)
Deciphering a function of a given protein requires investigating various biological aspects. Usually, the protein of interest is expressed with a fusion tag that aids or allows subsequent analyses. Additionally, downregulation or inactivation of the
Externí odkaz:
https://doaj.org/article/5a180779111c48eab736888d65918961
Publikováno v:
WIREs RNA. 13
Mitochondria play a pivotal role in numerous cellular processes. One of them is regulation of the innate immune pathway. In this instance, mitochondria function in two different aspects of regulatory mechanisms. First, mitochondria are part of the an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa48cb6d358af18cb61c8703aa4b7ad
https://doi.org/10.1002/wrna.1690
https://doi.org/10.1002/wrna.1690
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7999, p 7999 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Mitochondria, often referred to as the powerhouses of cells, are vital organelles that are present in almost all eukaryotic organisms, including humans. They are the key energy suppliers as the site of adenosine triphosphate production, and are invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df680a97f895f6d989aa45c37f56bfe3
https://www.mdpi.com/1422-0067/22/15/7999
https://www.mdpi.com/1422-0067/22/15/7999
Autor:
Lukasz S. Borowski, Roman J. Szczesny
Publikováno v:
The FEBS Journal. 288:434-436
Mitochondria are peculiar organelles because their function depends on genetic information that is present in two genomes: nuclear and mitochondrial. The expression of mitochondrially encoded information requires dedicated machinery. Many efforts hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa593c89a516a0fdeb63617844bde027
https://doi.org/10.1111/febs.15435
https://doi.org/10.1111/febs.15435