Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Roman Hrstka"'
Autor:
Lucia Janacova, Michaela Stenckova, Petr Lapcik, Sarka Hrachovinova, Pavla Bouchalova, David Potesil, Roman Hrstka, Petr Müller, Pavel Bouchal
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Catechol-O-methyl transferase (COMT) is involved in detoxification of catechol estrogens, playing cancer-protective role in cells producing or utilizing estrogen. Moreover, COMT suppressed migration potential of breast cancer (BC) cells. To
Externí odkaz:
https://doaj.org/article/b1c0c33a529140bdaa207c91df10f273
Autor:
Ravery Sebuyoya, Ludmila Moranova, Nasim Izadi, Lukas Moran, Roman Hrstka, Milan Anton, Martin Bartosik
Publikováno v:
Biosensors and Bioelectronics: X, Vol 12, Iss , Pp 100224- (2022)
Electrochemical (EC) biosensors are potentially useful tools for detection of DNA and RNA cancer biomarkers. Gold screen-printed electrodes (AuSPEs) are especially popular due to their easy manufacturing and surface modifications, making them useful
Externí odkaz:
https://doaj.org/article/6f3edfefbac4410b9854031884dd8b69
Autor:
Denise Wolrab, Robert Jirásko, Eva Cífková, Marcus Höring, Ding Mei, Michaela Chocholoušková, Ondřej Peterka, Jakub Idkowiak, Tereza Hrnčiarová, Ladislav Kuchař, Robert Ahrends, Radana Brumarová, David Friedecký, Gabriel Vivo-Truyols, Pavel Škrha, Jan Škrha, Radek Kučera, Bohuslav Melichar, Gerhard Liebisch, Ralph Burkhardt, Markus R. Wenk, Amaury Cazenave-Gassiot, Petr Karásek, Ivo Novotný, Kristína Greplová, Roman Hrstka, Michal Holčapek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Patients with pancreatic cancer have a poor prognosis, more research is required to identify the disease at an earlier stage. Here, the authors use lipid profiles of blood samples and show that they can distinguish patients with pancreatic cancer fro
Externí odkaz:
https://doaj.org/article/fab714422846417696ab9c2c63c8d5e0
Autor:
Andrea Martisova, Lucia Sommerova, Adam Krejci, Iveta Selingerova, Tamara Kolarova, Filip Zavadil Kokas, Milos Holanek, Jan Podhorec, Tomas Kazda, Roman Hrstka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10845 (2022)
The TGF-β signaling pathway is involved in numerous cellular processes, and its deregulation may result in cancer development. One of the key processes in tumor progression and metastasis is epithelial to mesenchymal transition (EMT), in which TGF-
Externí odkaz:
https://doaj.org/article/3180081033df4b7b973492ac34e9ebd2
Autor:
Milos Holanek, Iveta Selingerova, Pavel Fabian, Oldrich Coufal, Ondrej Zapletal, Katarina Petrakova, Tomas Kazda, Roman Hrstka, Alexandr Poprach, Maria Zvarikova, Ondrej Bilek, Marek Svoboda
Publikováno v:
Diagnostics, Vol 12, Iss 7, p 1740 (2022)
A residual cancer burden after neoadjuvant therapy (NAT) for breast cancer (BC) is associated with worse treatment outcomes compared to patients who achieved pathologic complete remission. This single-institutional retrospective study of 767 consecut
Externí odkaz:
https://doaj.org/article/683bdd4ed2e2407987165083b0d972a6
Autor:
Petr Muller, Philip J. Coates, Rudolf Nenutil, Filip Trcka, Roman Hrstka, Josef Chovanec, Veronika Brychtova, Borivoj Vojtesek
Publikováno v:
Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-7 (2019)
Abstract Background Increased activity of the chaperones Hsp70 and Hsp90 is a common feature of solid tumours. Translocase of the outer mitochondrial membrane 34 (Tomm34) is a cochaperone of both Hsp70 and Hsp90 that was found to be overexpressed in
Externí odkaz:
https://doaj.org/article/d42bc5eeaed94b09aa3eb8911acdc4b8
Autor:
Jitka Holcakova, Martin Bartosik, Milan Anton, Lubos Minar, Jitka Hausnerova, Marketa Bednarikova, Vit Weinberger, Roman Hrstka
Publikováno v:
Cancers, Vol 13, Iss 24, p 6339 (2021)
The prevention and early diagnostics of precancerous stages are key aspects of contemporary oncology. In cervical cancer, well-organized screening and vaccination programs, especially in developed countries, are responsible for the dramatic decline o
Externí odkaz:
https://doaj.org/article/6462569efdf74d2db28fb959e51cda1f
Autor:
Barbora Zwinsová, Vyacheslav A. Petrov, Martina Hrivňáková, Stanislav Smatana, Lenka Micenková, Natálie Kazdová, Vlad Popovici, Roman Hrstka, Roman Šefr, Beatrix Bencsiková, Lenka Zdražilová-Dubská, Veronika Brychtová, Rudolf Nenutil, Petra Vídeňská, Eva Budinská
Publikováno v:
Cancers, Vol 13, Iss 19, p 4799 (2021)
Long-term dysbiosis of the gut microbiome has a significant impact on colorectal cancer (CRC) progression and explains part of the observed heterogeneity of the disease. Even though the shifts in gut microbiome in the normal-adenoma-carcinoma sequenc
Externí odkaz:
https://doaj.org/article/29fb4d06ea9044ac81fb3352040678a3
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background During cancer progression, epithelial cancer cells can be reprogrammed into mesenchymal-like cells with increased migratory potential through the process of epithelial-mesenchymal transition (EMT), representing an essential step o
Externí odkaz:
https://doaj.org/article/f2e9f83329c04413a439dee225eceb1e
Autor:
Andrea Martisova, Jitka Holcakova, Nasim Izadi, Ravery Sebuyoya, Roman Hrstka, Martin Bartosik
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4247 (2021)
DNA methylation, i.e., addition of methyl group to 5′-carbon of cytosine residues in CpG dinucleotides, is an important epigenetic modification regulating gene expression, and thus implied in many cellular processes. Deregulation of DNA methylation
Externí odkaz:
https://doaj.org/article/cbed9493b14d4569bee142cb53a9f43c