Výsledky vyhledávání - "Roman Holič"

Yeast Sec14-like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol

Autor: Dominik Šťastný, Lívia Petrisková, Dana Tahotná, Jacob Bauer, Lucia Pokorná, Roman Holič, Martin Valachovič, Vladimír Pevala, Shamshad Cockcroft, Peter Griač

Publikováno v: FEBS letters.

Yeast Sec14-like phosphatidylinositol transfer proteins (PITPs) contain a hydrophobic cavity capable of accepting a single molecule of phosphatidylinositol (PI) or another molecule in a mutually exclusive manner. We report here that two yeast Sec14 f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca26dab7bcf0c38f85199acd669ee78f
https://pubmed.ncbi.nlm.nih.gov/36482167

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Phosphatidylinositol binding of Saccharomyces cerevisiae Pdr16p represents an essential feature of this lipid transfer protein to provide protection against azole antifungals

Autor: Roman, Holič, Zuzana, Simová, Tim, Ashlin, Vladimír, Pevala, Katarína, Poloncová, Dana, Tahotná, Eva, Kutejová, Shamshad, Cockcroft, Peter, Griač

Publikováno v: Biochimica et Biophysica Acta

Pdr16p is considered a factor of clinical azole resistance in fungal pathogens. The most distinct phenotype of yeast cells lacking Pdr16p is their increased susceptibility to azole and morpholine antifungals. Pdr16p (also known as Sfh3p) of Saccharom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::596ff62f6511c69f123c2d85df34ef19
https://pubmed.ncbi.nlm.nih.gov/25066473

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The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals

Autor: Zuzana, Šimová, Katarína, Poloncová, Dana, Tahotná, Roman, Holič, Ivan, Hapala, Adam R, Smith, Theodore C, White, Peter, Griač

Publikováno v: Yeast (Chichester, England). 30(6)

Pdr16p belongs to the family of phosphatidylinositol transfer proteins in yeast. The absence of Pdr16p results in enhanced susceptibility to azole antifungals in Saccharomyces cerevisiae. In the major fungal human pathogen Candida albicans, CaPDR16 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8156c13af463e914c3e46a2ad6ad21b4
https://pubmed.ncbi.nlm.nih.gov/23606207

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