Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Roman Groisberg"'
Publikováno v:
Sarcoma, Vol 2024 (2024)
The classification of undifferentiated pleomorphic sarcoma (UPS) has been evolving with advances in immunohistochemistry and genomic profiling over the past 20 years. There is a lack of current information on UPS incidence. Due to the lack of designa
Externí odkaz:
https://doaj.org/article/37df9bed37254ebb85248b897dc0bd8d
Autor:
Omar Alhalabi, Roman Groisberg, Ralph Zinner, Andrew W. Hahn, Aung Naing, Shizhen Zhang, Apostolia M. Tsimberidou, Jordi Rodon, Siqing Fu, Timothy A. Yap, David S. Hong, Ming Sun, Yunfang Jiang, Shubham Pant, Amishi Y. Shah, Amado Zurita, Nizar M. Tannir, Raghunandan Vikram, Jason Roszik, Funda Meric-Bernstam, Vivek Subbiah
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-10 (2023)
Abstract Pre-clinically, the mTORC1/2 inhibitor sapanisertib restored sensitivity to platinums and enhanced paclitaxel-induced cancer cell killing. NCT03430882 enrolled patients with mTOR pathway aberrant tumors to receive sapanisertib, carboplatin a
Externí odkaz:
https://doaj.org/article/0e41dd980da3400cb70f16af34c1c22a
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
BackgroundImmune checkpoint inhibitors (ICI) are standard of care therapy for patients with cutaneous malignancies, the most frequently diagnosed cancers in solid organ transplant (SOT) recipients. The activity and rate of allograft rejection in SOT
Externí odkaz:
https://doaj.org/article/476fe1a883574bc08e9b94670c9a6a7d
Autor:
Ann W. Silk, Biren Saraiya, Roman Groisberg, Nancy Chan, Kristen Spencer, Eugenia Girda, Weichung Shih, Marisa Palmeri, Tracie Saunders, Robert M. Berman, Vlad Coric, Suzie Chen, Andrew Zloza, Joshua Vieth, Janice M. Mehnert, Jyoti Malhotra
Publikováno v:
European Journal of Medical Research, Vol 27, Iss 1, Pp 1-7 (2022)
Abstract Background Glutamate signaling activates MAPK and PI3K/AKT pathways in tumor cells. Treatment with riluzole, a glutamate release inhibitor, has been previously shown to be safe in melanoma patients and produced biologic effects, but did not
Externí odkaz:
https://doaj.org/article/016991f14f514560b82ba32849371847
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Cutaneous angiosarcoma (cAS) is a rare and aggressive subtype of soft tissue sarcoma with poor prognosis and suboptimal treatment options. Clinical presentation is variable, but cAS often arises from the head and neck. The most widely accepted curren
Externí odkaz:
https://doaj.org/article/c687a39093de428fabdad486bc363f16
Publikováno v:
Case Reports in Oncology, Vol 14, Iss 3, Pp 1580-1585 (2021)
Angiosarcoma is an uncommon malignancy with a poor prognosis. Systemic therapy options for patients with metastatic disease generally have limited effectiveness. In this case study, a 73-year-old male with metastatic angiosarcoma who previously decli
Externí odkaz:
https://doaj.org/article/11781034e0c34366bdad1c958c3619c5
Autor:
Montaser F Shaheen, Julie Y Tse, Ethan S Sokol, Margaret Masterson, Pranshu Bansal, Ian Rabinowitz, Christy A Tarleton, Andrey S Dobroff, Tracey L Smith, Thèrése J Bocklage, Brian K Mannakee, Ryan N Gutenkunst, Joyce Bischoff, Scott A Ness, Gregory M Riedlinger, Roman Groisberg, Renata Pasqualini, Shridar Ganesan, Wadih Arap
Publikováno v:
eLife, Vol 11 (2022)
Background: Lymphatic malformations (LMs) often pose treatment challenges due to a large size or a critical location that could lead to disfigurement, and there are no standardized treatment approaches for either refractory or unresectable cases. Met
Externí odkaz:
https://doaj.org/article/c6163aac82254054b261cfba4ae2852f
Autor:
Isaac M. Tessone, Benjamin Lichtbroun, Arnav Srivastava, Alexandra L. Tabakin, Charles F. Polotti, Roman Groisberg, Evita Sadimin, Eric A. Singer, Miral S. Grandhi
Publikováno v:
Journal of Kidney Cancer and VHL, Vol 9, Iss 2 (2022)
Renal angiomyolipomas (AMLs) are a subset of perivascular epithelioid cell neoplasms (PEComas) that are associated with tuberous sclerosis complex (TSC). Epithelioid angiomyolipomas (EAMLs) are a rare variant of AML with more aggressive propensities.
Externí odkaz:
https://doaj.org/article/2cc8a8b7b1aa47358463fe4d3c237531
Autor:
Israel Lowy, Roman Groisberg, Nehal Lakhani, Melissa Mathias, Siyu Li, Melissa Johnson, Frank Seebach, Matthew Fury, Hyunsil Han, Kerry Casey, Dimitris Skokos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/4b4e264a11ce43b6979c1d79a9b3d579
Autor:
Jyoti Malhotra, Janice M Mehnert, Ann W Silk, Roman Groisberg, Shang-Jui Wang, Karishma Khullar, Sinae Kim, Nikhil Yegya-Raman, Samuel H Crayton, John L Nosher, Michael A Gentile, Salma K Jabbour
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Immune checkpoint inhibitors (ICIs) improve survival outcomes in metastatic melanoma and non-small cell lung cancer (NSCLC). Preclinical evidence suggests that overexpression of cyclo-oxygenase-2 (COX2) in tumors facilitates immune evasion
Externí odkaz:
https://doaj.org/article/9b8f771430a647aebea7f7b8c4dfb698