Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Roman Galetto"'
Autor:
Arianna Moiani, Gil Letort, Sabrina Lizot, Anne Chalumeau, Chloe Foray, Tristan Felix, Diane Le Clerre, Sonal Temburni-Blake, Patrick Hong, Sophie Leduc, Noemie Pinard, Alan Marechal, Eduardo Seclen, Alex Boyne, Louisa Mayer, Robert Hong, Sylvain Pulicani, Roman Galetto, Agnès Gouble, Marina Cavazzana, Alexandre Juillerat, Annarita Miccio, Aymeric Duclert, Philippe Duchateau, Julien Valton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Sickle cell disease is a devastating blood disorder that originates from a single point mutation in the HBB gene coding for hemoglobin. Here, we develop a GMP-compatible TALEN-mediated gene editing process enabling efficient HBB correction v
Externí odkaz:
https://doaj.org/article/a5ed07ba92514c729d823ca1c6aa5120
Autor:
Roman Galetto, Tuna Mutis, Sonja Zweegman, Isabelle Chion-Sotinel, Charlotte L B M Korst, Chloe O’Neill, Wassilis S C Bruins, Meliha Cosovic, Inoka Twickler, Christie P M Verkleij, Diane Le Clerre, Maria Themeli, Niels W C J van de Donk
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Autologous BCMA-specific CAR T-cell therapies have substantial activity in multiple myeloma (MM). However, due to logistical limitations and BCMAlow relapses, there is a need for alternatives. UCARTCS1 cells are ‘off-the-shelf’ allogen
Externí odkaz:
https://doaj.org/article/c17a750a107e47f8ac1bda596a2df680
Meganuclease targeting HSV-1 protects against herpetic keratitis: Application to corneal transplants
Autor:
Benoit Chapellier, Damien Guindolet, Daniel Pereira, Roman Galetto, José-Alain Sahel, Marc Labetoulle, Eric E. Gabison
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 511-521 (2022)
Herpes simplex virus (HSV) infection is a leading cause of corneal blindness. However, keratoplasty is only rarely proposed due to the high frequency of graft failure and associated recurrences. Gene therapy of the corneal graft might provide sustain
Externí odkaz:
https://doaj.org/article/8bccc062a5bd497bb5041e2d4f5bafdb
Autor:
Sumin Jo, Shipra Das, Alan Williams, Anne-Sophie Chretien, Thomas Pagliardini, Aude Le Roy, Jorge Postigo Fernandez, Diane Le Clerre, Billal Jahangiri, Isabelle Chion-Sotinel, Sandra Rozlan, Emilie Dessez, Agnes Gouble, Mathilde Dusséaux, Roman Galetto, Aymeric Duclert, Emanuela Marcenaro, Raynier Devillier, Daniel Olive, Philippe Duchateau, Laurent Poirot, Julien Valton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destructi
Externí odkaz:
https://doaj.org/article/a2496c352a3244febe307778e8da45cb
Autor:
Tianyu Cai, Agnès Gouble, Kathryn L. Black, Anna Skwarska, Ammar S. Naqvi, Deanne Taylor, Ming Zhao, Qi Yuan, Mayumi Sugita, Qi Zhang, Roman Galetto, Stéphanie Filipe, Antonio Cavazos, Lina Han, Vinitha Kuruvilla, Helen Ma, Connie Weng, Chang-Gong Liu, Xiuping Liu, Sergej Konoplev, Jun Gu, Guilin Tang, Xiaoping Su, Gheath Al-Atrash, Stefan Ciurea, Sattva S. Neelapu, Andrew A. Lane, Hagop Kantarjian, Monica L. Guzman, Naveen Pemmaraju, Julianne Smith, Andrei Thomas-Tikhonenko, Marina Konopleva
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic malignancy derived from the precursors of plasmacytoid dendritic cells. Here the authors characterize the anti-tumor activity of allogeneic anti-CD123 CA
Externí odkaz:
https://doaj.org/article/28ec66e39af349c1b7a1e856e77e57a0
Autor:
Mayumi Sugita, Roman Galetto, Hongliang Zong, Nathan Ewing-Crystal, Vicenta Trujillo-Alonso, Nuria Mencia-Trinchant, Winnie Yip, Stephanie Filipe, Celine Lebuhotel, Agnès Gouble, Duane C. Hassane, Julianne Smith, Gail J. Roboz, Monica L. Guzman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
CD123, the interleukin-3 receptor alpha chain, is aberrantly expressed in acute myeloid leukemia blasts and leukemia stem cells. Here the authors report the design and characterize the anti-tumor activity of allogeneic CD123-targeted CAR-T cells as a
Externí odkaz:
https://doaj.org/article/45f0693affa74393899beaac1aead79c
Autor:
Martine Aubert, Daniel E. Strongin, Pavitra Roychoudhury, Michelle A. Loprieno, Anoria K. Haick, Lindsay M. Klouser, Laurence Stensland, Meei-Li Huang, Negar Makhsous, Alexander Tait, Harshana S. De Silva Feelixge, Roman Galetto, Philippe Duchateau, Alexander L. Greninger, Daniel Stone, Keith R. Jerome
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Abstract We evaluate gene editing of HSV in a well-established mouse model, using adeno-associated virus (AAV)-delivered meganucleases, as a potentially curative approach to treat latent HSV infection. Here we show that AAV-delivered meganucleases, b
Externí odkaz:
https://doaj.org/article/f4d037a80a34400ba2411e4046361719
Autor:
Agnes Gouble, Roman Galetto, Cécile Schiffer-Mannioui, Sophie Leduc, Isabelle Chion-Sotinel, Diane le Clerre, Valérie Guyot, Marco Rotondi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/c92e43cc8cdd42c7bddaa15ec507f2a7
Autor:
Zita Garate, Oscar Quintana-Bustamante, Ana M. Crane, Emmanuel Olivier, Laurent Poirot, Roman Galetto, Penelope Kosinski, Collin Hill, Charles Kung, Xabi Agirre, Israel Orman, Laura Cerrato, Omaira Alberquilla, Fatima Rodriguez-Fornes, Noemi Fusaki, Felix Garcia-Sanchez, Tabita M. Maia, Maria L. Ribeiro, Julian Sevilla, Felipe Prosper, Shengfang Jin, Joanne Mountford, Guillermo Guenechea, Agnes Gouble, Juan A. Bueren, Brian R. Davis, Jose C. Segovia
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 1053-1066 (2015)
Pyruvate kinase deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene. Erythrocytes from PKD patients show an energetic imbalance causing chronic non-spherocytic hemolytic anemia, as pyruvate kinase defects impai
Externí odkaz:
https://doaj.org/article/c4e6f66da3a7499d96a1b9ff98b4f2e1
Autor:
Martine Aubert, Nicole M Boyle, Daniel Stone, Laurence Stensland, Meei-Li Huang, Amalia S Magaret, Roman Galetto, David J Rawlings, Andrew M Scharenberg, Keith R Jerome
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Following acute infection, herpes simplex virus (HSV) establishes latency in sensory neurons, from which it can reactivate and cause recurrent disease. Available antiviral therapies do not affect latent viral genomes; therefore, they do not prevent r
Externí odkaz:
https://doaj.org/article/75315e5de9ce43a89af760b711a5b7fd